Publications by authors named "Hyeon-Ji Lim"

Colorectal cancer (CRC) is one of the most prevalent causes of cancer-related fatalities globally, and its development is closely associated with dietary and microbial factors. The aim of this study was to investigate the potential of ganjang, a traditional fermented soy sauce, in alleviating colitis-associated colorectal cancer (CAC) in a mouse model induced by azoxymethane/dextran sulfate sodium (AOM/DSS). The bacterial composition of ganjang samples from different regions primarily included spp.

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Inflammatory bowel disease (IBD), characterized by chronic inflammation of the gut, is caused by several factors. Among these factors, microbial factors are correlated with the gut microbiota, which produces short-chain fatty acids (SCFAs) via anaerobic fermentation. Fermented foods are known to regulate the gut microbiota composition.

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Article Synopsis
  • - Colorectal cancer (CRC), a prevalent cancer type linked to factors like chronic inflammation, was examined for its potential connection to Cheonggukjang (CJ), a traditional Korean fermented soybean known for its anti-inflammatory properties.
  • - In a mouse model simulating colitis-associated colorectal cancer, CJ showed significant protective effects by reducing symptoms like colonic shortening and tumor formation, as well as by affecting inflammatory cytokine levels.
  • - The study found that CJ not only improved gut integrity but also inhibited tumor growth by regulating cell processes like apoptosis and proliferation, showcasing its potential as an anti-cancer agent.
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Inflammatory bowel disease (IBD) is a chronic inflammatory disease, and the incidence of IBD is increasing every year owing to changes in dietary structure. Although the exact pathogenesis of IBD is still unclear, recent evidence suggests that gut dysbiosis is closely associated with IBD pathogenesis. is a traditional Korean fermented soybean paste produced using traditional and industrial methods, and contains probiotics, which affect the gut microbiota composition.

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is used in folk medicine to treat pain and allergic syndromes in Korea. However, the antibacterial and anti-inflammatory activities of callus extract remain unexplored. In this study, we aimed to evaluate the callus of pharmacological activity.

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Quercetin is a well-known antioxidant and a plant polyphenolic of flavonoid group found in many fruits, leaves, and vegetables. Propionibacterium acnes is a key skin pathogen involved in the progression of acne inflammation. Although quercetin has been applied to treat various inflammatory diseases, the effects of quercetin on P.

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has been traditionally used to treat dysentery, enteritis, flatulence, and itchiness. However, the existence of anti-inflammatory effects of on -induced skin disease is unknown. In vitro cultures of plant cells and tissues produced under controlled conditions offer a continuous production platform for plant natural products including pigments and anti-inflammatory agents.

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Background: Euphorbia supina (ES) plant has been used as treatment for inflammatory conditions. The antibacterial effect and the anti-inflammatory mechanism of ES for Propionibacterium (P.) acnes-induced inflammation in THP-1 cells and acne animal model remain unclear.

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Article Synopsis
  • The study analyzed volatile compounds in brown and white rice after fermentation with Lactobacillus paracasei using gas chromatography-mass spectrometry (GC-MS).
  • Fermented brown rice had higher levels of esters, alcohols, lactones, and certain aldehydes due to its higher free fatty acid content, particularly increasing γ-lactones.
  • The addition of 4-hydroxydecanoic acid significantly boosted γ-decalactone levels in fermented brown rice, suggesting it enhances the formation of this compound during fermentation.
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