Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma.

Purpose: This study evaluates the prognostic performance of a 15 gene expression profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic subgroups: class 1 (low metastatic risk) and class 2 (high metastatic risk).

Design: Prospective, multicenter study.

Participants: A total of 459 patients with posterior uveal melanoma were enrolled from 12 independent centers.

Clinical and ultrasound biomicroscopy features associated with growth in iris melanocytic lesions.

Purpose: To determine the clinical and ultrasound biomicroscopy (UBM) features associated with growth in iris melanocytic lesions.

Study Design: Retrospective case series analysis.

Methods: We included all iris melanocytic lesions that were monitored between January 2005 and November 2009.

Intraocular extension of conjunctival invasive squamous cell carcinoma after pterygium surgery and cataract extraction.

Objectives: Conjunctival squamous dysplasia can often be confused with pterygium and pinguecula. Incomplete excision of dysplastic tissue can lead to recurrence and rarely intraocular invasion. This study describes two cases in which invasive squamous cell carcinoma (SCC) of the conjunctiva was originally partially resected as pterygium and eventually required enucleation for intraocular invasion.

Ultrasound biomicroscopic imaging of iris melanoma: a clinicopathologic study.

Purpose: To demonstrate the correlation of ultrasound biomicroscopy (UBM) features of iris melanoma with histopathology.

Design: Retrospective analysis of medical records.

Methods: The medical records of patients that underwent surgery for iris melanoma at the Princess Margaret Hospital, University of Toronto, from June 1990 to October 1998 were reviewed.

Management of iris melanomas with 125Iodine plaque radiotherapy.

Purpose: To report the experience of the Princess Margaret Hospital/University Health Network with the treatment of iris melanoma (IM) with (125)Iodine plaque brachytherapy.

Design: Retrospective noncomparative case series.

Methods: All cases of IM submitted to (125)Iodine plaque radiotherapy were included.