Isoliensinine Induces Ferroptosis in Urothelial Carcinoma Cells via the PI3K/AKT/HIF-1α Axis: Molecular Evidence from Next-Generation Sequencing.

Bladder cancer ranks ninth among the most commonly diagnosed cancers, with urothelial carcinoma (UC) accounting for more than 90% of all cases. Given the high recurrence rate and progression risk of bladder cancer, investigating alternative adjunct therapies is imperative. One potential candidate is isoliensinine, which has shown antitumor potential in various cancers; however, the effectiveness of isoliensinine on UC is largely unknown.

A systematic review and network meta-analysis of surgical interventions for glaucoma following penetrating keratoplasty.

This study aims to compare the effectiveness and safety of surgical interventions for secondary glaucoma following penetrating keratoplasty (PKP) through a network meta-analysis. PubMed, Cochrane Central Register of Controlled Trials, Embase, Web of Science, Scopus, and Google Scholar databases were searched for articles published from inception to July 16, 2024. We included studies that compared the effects of trabeculectomy, glaucoma drainage devices (GDDs), or cyclophotocoagulation (CPC) on graft failure, intraocular pressure (IOP), or the number of glaucoma medications required for patients with post-PKP glaucoma.

Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus.

Diabetic retinopathy (DR) is a leading cause of vision loss among adults. This study evaluates Optical Coherence Tomography Angiography (OCTA) vessel density (VD) as a marker for DR in diabetes mellitus (DM) patients. An observational study was conducted with 47 type 2 DM patients and 21 healthy controls.