Publications by authors named "Hsiuwen Chang"

Article Synopsis
  • Increased medical attention is crucial as autism spectrum disorder (ASD) prevalence increases, with significant associations found between ASD and cardiovascular disorders (CVD) like hyperlipidemia.
  • The study hypothesized that the Shank3 gene contributes to the development of CVD in young adults with ASD by investigating its role in atherosclerosis through various analyses, including knockout mice and human studies from Taiwan.
  • Findings suggested that Shank3 downregulation leads to altered cholesterol metabolism and reduced inflammatory responses, indicating that regulating Shank3 could help mitigate inflammation-related disorders linked to early-onset atherosclerosis and CVD in individuals with ASD.
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Purpose: The purpose of this study was to comprehensively monitor the auditory skill development of children with hearing loss after hearing instrument fitting, and a battery of four assessments was proposed.

Method: This battery was designed to fill the gap in speech discrimination in clinically available evaluations. The battery includes both behavioral and neural assessments.

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Background And Objectives: Hearing thresholds across frequencies must be obtained for hearing aid fitting. Narrow-band noise (NBN) and speech sounds are often used as stimuli in pediatric audiologic assessments to elicit children's attention due to their wider frequency ranges as compared to pure tones. However, obtaining complete responses across frequency ranges is challenging in pediatric practice.

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Urinoma, defined as the urine leakage beyond the urinary tract, is commonly induced by blunt trauma or urinary tract obstruction by stone, intra-abdominal malignancy, or retroperitoneal fibrosis. Spontaneous urinoma is rare and parenchymal pathologic change is rarely mentioned when urinoma is found. We present a case of a 28-year-old woman with bilateral flank pain induced by spontaneous urinoma.

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Article Synopsis
  • A study aimed to determine if hearing thresholds assessed via auditory brainstem response (ABR) in infants can predict behavioral pure-tone audiometry (PTA) thresholds in children, using data from a newborn hearing screening program in Taiwan.
  • The research included 104 newborns, focusing on their ABR thresholds and subsequent PTA thresholds, analyzed through correlation and regression methods.
  • Results showed a strong correlation (0.76) between ABR and PTA thresholds, suggesting that while ABR can provide a reliable estimate for behavioral PTA in many cases, it is recommended to combine different ABR methods for precise hearing aid fittings and rehabilitation.
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With the introduction of newborn hearing screening, infants are being diagnosed with hearing loss during the first few months of life. For infants with a sensory/neural hearing loss (SNHL), the audiogram can be estimated objectively using auditory brainstem response (ABR) testing and hearing aids prescribed accordingly. However, for infants with auditory neuropathy spectrum disorder (ANSD) due to the abnormal/absent ABR waveforms, alternative measures of auditory function are needed to assess the need for amplification and evaluate whether aided benefit has been achieved.

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Article Synopsis
  • The study aimed to evaluate newborn hearing screening in well-baby and neonatal intensive care units by measuring the effectiveness of screening, referral, and diagnostic follow-up rates, comparing the average diagnosis age, and determining the prevalence of hearing loss.
  • Out of 15,624 newborns screened, the results showed high screening rates, but NICU patients had a lower referral rate and a longer average age for diagnosis compared to well-baby nursery patients.
  • Despite equivalent screening and follow-up rates, the prevalence of congenital bilateral hearing loss was significantly higher in the NICU group, suggesting a need for tailored screening approaches in these vulnerable infants.
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Hardware sensors embedded in a smartphone allow the device to become an excellent mobile navigator. A smartphone is ideal for this task because its great international popularity has led to increased phone power and since most of the necessary infrastructure is already in place. However, using a smartphone for indoor pedestrian navigation can be problematic due to the low accuracy of sensors, imprecise predictability of pedestrian motion, and inaccessibility of the Global Navigation Satellite System (GNSS) in some indoor environments.

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Objective: To determine the effectiveness of objective statistical detection in CAEP testing to evaluate audibility in young infants with sensorineural hearing loss.

Design: CAEP recordings to speech-based stimuli were made at three presentation levels (55, 65, or 75 dB SPL) when a group of hearing-impaired infants were either aided or unaided. Later-obtained behavioral audiograms were used as the gold standard against which to evaluate the accuracy of the automatic detection of the presence/absence of CAEP responses.

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Mobile mapping systems have been widely applied for acquiring spatial information in applications such as spatial information systems and 3D city models. Nowadays the most common technologies used for positioning and orientation of a mobile mapping system include a Global Positioning System (GPS) as the major positioning sensor and an Inertial Navigation System (INS) as the major orientation sensor. In the classical approach, the limitations of the Kalman Filter (KF) method and the overall price of multi-sensor systems have limited the popularization of most land-based mobile mapping applications.

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Digital mobile mapping, which integrates digital imaging with direct geo-referencing, has developed rapidly over the past fifteen years. Direct geo-referencing is the determination of the time-variable position and orientation parameters for a mobile digital imager. The most common technologies used for this purpose today are satellite positioning using Global Positioning System (GPS) and Inertial Navigation System (INS) using an Inertial Measurement Unit (IMU).

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Background: Deep brain stimulation (DBS) has re-emerged as an alternative therapy for intractable epilepsy. In this study, we investigated the feasibility, efficacy and safety of long-term anterior thalamic nucleus (ATN) stimulation for intractable epilepsy.

Methods: In this open-label pilot study of electrical stimulation of the ATN, we investigated four cases of intractable epilepsy (one man with generalized seizure, and three woman with partial seizure and secondary generalization; age range, 18-45 years), with a follow up of 2 years.

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Purpose: The anterior nucleus of the thalamus (ANT) modulates temporal lobe and hypothalamic activities, and relays information to the cingulate gyrus and entorhinal cortex. Deep brain stimulation (DBS) of the ANT has been reported to decrease seizure activity in a limited number of human subjects. However, long-term effect of chronic ANT stimulation on such patients remains unknown.

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