Publications by authors named "Hsiang-Lin Song"
Sepsis presents a significant medical challenge due to its intense inflammatory response to infection, often resulting in high mortality rates. A promising therapeutic strategy targets the cholinergic anti-inflammatory pathway (CAIP), which regulates immune responses. This study investigates the ingestion of piezoelectric particles that adhere to the stomach lining, specifically targeting TRPV1 receptors.
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- Phosphaturic mesenchymal tumors (PMTs) are rare tumors linked to low phosphate levels in the body, primarily due to the secretion of fibroblast growth factor 23.
- In a study of a larger PMT cohort, some tumors previously classified as "fusion-negative" were re-identified as fusion-positive with newly discovered genetic fusions, including FN1::ZACN.
- The research also found that many fusion-negative PMTs exhibited overexpression of KL/α-Klotho, with notable genetic rearrangements, hinting at underlying mechanisms affecting KL regulation that merit further inquiry.
Article Synopsis
- The prognosis for pancreatic ductal adenocarcinoma (PDAC) is poor due to its challenging tumor microenvironment, leading to the development of a new targeted treatment using β-glucans-functionalized zinc-doxorubicin nanoparticles (βGlus-ZnD NPs).
- The nanoparticles can be taken orally, effectively targeting and passing through intestinal barriers to reach the tumor tissue by utilizing macrophages to transport them through the body.
- This treatment not only delivers the drug to the tumor but also activates the macrophages to modify the tumor microenvironment and recruit immune cells, enhancing tumor cell death and reducing metastasis when combined with immune checkpoint blockade.
Article Synopsis
- The study investigates the relationship between lymphadenopathy with increased IgG4 + plasma cells and immunoglobulin G4-related disease (IgG4-RD) by analyzing 55 lymph node biopsy specimens from patients.
- It explores whether specific pathological features in lymph nodes are indicative of IgG4-RD and compares patients who developed additional manifestations of IgG4-RD to those who did not.
- The findings reveal minor significant differences between the two groups, particularly in treatment frequency and C-reactive protein levels, while many other characteristics showed no significant variations.
Article Synopsis
- A biomaterial-based scaffold made of radially aligned mineralized collagen fibers with nanosilicon (RA-MC/nSi) is proposed to address large bone defects that cannot heal on their own.
- In studies using a mouse model, this scaffold effectively promotes the movement and growth of reparative cells toward the defect site, enhancing bone healing.
- The scaffold releases gaseous hydrogen and silicic acid, helping to control inflammation and boost the regeneration of bone tissue by promoting cell growth and differentiation.
Article Synopsis
- - RCC-RF is a tough-to-treat type of kidney cancer in adults that doesn't respond well to standard chemotherapy, and it often shows reduced expression of the INI1 gene.
- - Research involved testing how the absence of INI1 affects cancer cell signaling and drug response, finding that lack of INI1 activated pathways related to cancer growth and made cells more sensitive to the drug Erlotinib.
- - The study suggests that INI1 loss might contribute to the development of RCC-RF, and indicates that Erlotinib could be a viable treatment option for patients with this specific cancer variant.
Article Synopsis
- - Small cell lung cancer (SCLC) has poor clinical outcomes due to the lack of effective long-term treatments, with the transcriptional factor FOXM1 playing a key role in cell proliferation and tumor progression.
- - Research indicates that FOXM1 is significantly upregulated in SCLC, correlating with pathways linked to cancer growth and DNA damage repair, and its depletion enhances sensitivity to chemotherapy.
- - High levels of FOXM1 expression in SCLC patients are associated with advanced disease, worse overall survival rates, and shorter progression-free survival after standard treatment, suggesting FOXM1 could serve as a valuable prognostic biomarker and therapeutic target.
Article Synopsis
- Researchers aimed to use quantitative image analysis on radiomic values to predict high-grade components in lung adenocarcinoma (ADC) subtypes, which have implications for pathology.
- They conducted studies on 103 patients (cohort 1) and 55 patients (cohort 2), employing methods like patch-wise prediction and comparing it with consolidation/tumor (C/T) ratios on CT images.
- Results showed high sensitivity and moderate specificity for detecting high-grade subtypes, particularly with patch-wise prediction, indicating the potential of radiomic features in cancer diagnostics.
Lung cancer is one of the leading causes of death worldwide. Fifteen percent of lung cancer patients will present with malignant pleural effusion initially, and up to 50% will have malignant pleural effusion throughout the course of the disease. In this study, we developed a spiral microfluidic device that can rapidly isolate cancer cells and improve their purity through fluid dynamics.
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- Pancreatic cancer treatment is currently ineffective, prompting researchers to develop an oral drug delivery system that creates gas bubbles to enhance drug absorption in the small intestine.
- This system delivers two drugs, paclitaxel (PTX) and gemcitabine (GEM), simultaneously, effectively targeting pancreatic tumors in a rat model with better results than traditional intravenous methods.
- The oral formulation not only avoids toxic side effects but also improves drug bioavailability and inhibits tumor growth more effectively, offering a safer and more convenient option for outpatient care.
Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype.
J Gastroenterol Hepatol
April 2020
Background And Aim: The clinicopathologic features of hepatocellular adenoma in Asian populations have been poorly defined. The study aimed to characterize this rare entity in a single institution in Taiwan.
Methods: In total, 45 hepatocellular adenomas from 1995 to 2018 were included and sent for pathologic review and molecular subtyping.
Article Synopsis
- The study investigates the role of microRNA-21 (miR-21) in the failure of arteriovenous fistulas (AVFs) due to venous neointimal hyperplasia (VNH) through both animal and laboratory experiments.
- Results show that miR-21 expression is significantly increased in failed AVFs, particularly in association with fibroblasts, indicating its potential role in the failure mechanism.
- Knocking down miR-21 in graft veins improved AVF patency and reduced neointima formation, suggesting that miR-21 promotes VNH by facilitating the differentiation of fibroblasts into myofibroblasts.
MicroRNA-21 and Venous Neointimal Hyperplasia of Dialysis Vascular Access.
Clin J Am Soc Nephrol
November 2018
Article Synopsis
- This study investigates the role of specific microRNAs (miRNAs) in the formation of neointima in patients undergoing dialysis, finding that miR-21, miR-130a, and miR-221 were upregulated while miR-133 and miR-145 were downregulated in stenotic tissues.
- The research involved analyzing venous tissues from dialysis patients and monitoring circulating miRNA levels before and after angioplasty, revealing that higher levels of circulating miR-21 post-procedure are linked to an increased risk of vascular access failure (restenosis) within six months.
- The findings suggest that measuring specific miRNAs could help predict complications in dialysis access and potentially guide treatment decisions.
Article Synopsis
- Inflammatory bowel disease (IBD) is a condition characterized by inflammation in the intestines, and there is a need for effective treatment methods.
- Diallyl trisulfide (DATS), an anti-inflammatory compound, struggles with poor water solubility, prompting the development of a new drug delivery system called CAP-w-FC.
- This system enables a self-assembled spray coating that delivers DATS directly to the colon, enhancing its absorption and facilitating the reduction of inflammation by transforming DATS into hydrogen sulfide (HS) in the body.
Long-term Sequelae of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
Acta Derm Venereol
May 2016
Article Synopsis
- - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin reactions from drugs, leading to skin and mucosal issues, and have limited long-term studies on their complications.
- - A study analyzed 102 patients from 1998 to 2012 and found that the most common long-term complications were skin and eye problems, affecting 44.1% of patients.
- - Additionally, some patients faced severe organ issues, including chronic kidney disease and lung disease, while six patients developed autoimmune disorders such as Sjögren's syndrome and systemic lupus erythematosus.
Article Synopsis
- * In an analysis of 29 female patients, 53% showed a monoclonal pattern in the HUMARA gene, with higher frequencies noted in larger lesions and stromal-rich variants.
- * Follow-up indicated that 17% of patients experienced persistent disease, but no significant immunoglobulin or T-cell receptor gene rearrangements were found, underscoring the distinct nature of hyaline vascular Castleman disease compared to other forms.
Delayed uterine rupture occurred 4 weeks after cesarean section following sexual intercourse: a case report and literature review.
Taiwan J Obstet Gynecol
September 2013
Article Synopsis
- - A case study reports a rare instance of spontaneous delayed uterine rupture occurring in a 31-year-old woman 4 weeks after a cesarean section, triggered by sexual intercourse.
- - The patient experienced shock and significant vaginal bleeding, necessitating an emergency subtotal hysterectomy to manage the situation.
- - Pathological examination revealed tissue necrosis and suture granuloma, highlighting the importance for obstetricians to be aware of the risks of delayed uterine rupture even in the absence of clear symptoms.
Article Synopsis
- The study explores the proliferation of plasmacytoid dendritic cells (PDCs) and Langerhans cells (LCs) in cases of reactive conditions and myeloproliferative disorders, focusing particularly on acute myeloid leukaemia in a 55-year-old man.
- It reports a rare instance of simultaneous tumorous growth of PDCs and LCs in lymph nodes, with genetic tests indicating they share a common origin linked to the patient's leukemia.
- The authors suggest that these cells arise from the same hematopoietic stem cells but take different developmental pathways influenced by their specific environments.