Pharmacokinetics of Cyclosporine A in Chinese heart transplant recipients.

Aim: To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients.

Methods: A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin peroxidase fluorescent polarization immunoassay.

BMP7 induces the differentiation of bone marrow-derived mesenchymal cells into chondrocytes.

Injured articular cartilage has a poor capacity for spontaneous healing. So far, a satisfactory solution to repair the injured cartilage has not been found, but transgenic therapy might be a promising treatment. This study aims to evaluate the potential of transfecting bone morphogenetic protein-7 (BMP-7), a secretory protein, into bone marrow-derived mesenchymal stem cells (BMSCs), in inducing the differentiation of bone marrow stromal cells into chondrocytes in vitro.