Analysis of Perfluoroalkyl Substances (PFASs) in Settled Dust by Liquid Chromatography with Tandem Mass Spectrometry: Method Validation and Application to Vietnamese House and Road Dusts.

Information about perfluoroalkyl substances (PFASs) like perfluoroalkyl carboxylic acids (PFCAs) and sulfonates (PFSs) in settled dust from emerging and developing countries is still limited, partly due to the lack of efficient analytical methods. In this study, a reliable, simple, and cost-effective analytical procedure was developed and validated to determine 12 PFCAs and 4 PFSs in dust samples. The samples were ultrasonicated with methanol, followed by a dispersive sorbent clean-up step with graphitized carbon and quantification by liquid chromatography with tandem mass spectrometry (LC-MS/MS) method.

Clinical and safety outcomes following endovascular treatment for large ischemic core stroke with Alberta Stroke Program Early Computed Tomography Score 3-5 in the 12-to 24-h time window.

Introduction: Although the efficacy and safety of endovascular treatment (EVT) for large-core ischemic stroke have been proven, most trials used perfusion imaging or included early-window patients, limiting generalizability to the late window, particularly in developing countries.

Aim: We aimed to evaluate the safety and functional outcomes of EVT in large-core stroke patients treated between 12 and 24 h (late window) from last known well (LKW).

Methods: We conducted a prospective, multicenter observational study across four comprehensive stroke centers in Vietnam, enrolling consecutive patients who underwent EVT within 24 h of symptom onset between August 2023 and September 2024.

RAD52 and RPA act in a concert promoting inverse RNA strand exchange.

Recent studies in eukaryotes have revealed an important role of RNA in DNA repair and identified the RAD52 protein as a central player in RNA-dependent repair of DNA. In vitro, RAD52 promotes inverse RNA strand exchange between dsDNA and homologous RNA. This reaction is strongly stimulated by the RAD52 partner, replication protein A (RPA).

Protective effect of metformin against dementia in patients with obesity: Results from a global federated health network analysis.

Aims: Metformin, a first-line medication for Type 2 diabetes (T2D), has been suggested to reduce dementia risk. We investigated whether metformin use was associated with lower long-term incidence of dementia and all-cause mortality in obese patients.

Materials And Methods: We analysed electronic health record data from the TriNetX network.

A Rare Case of Asymmetric Periorbital Edema due to Delayed Hypersensitivity Reaction to Thyroid Hormone Replacement.

Background/objective: Hypersensitivity reactions to medications often exhibit identifiable symptoms, yet their diagnosis can be challenging due to individual variability. Although hypersensitivity reactions to levothyroxine are rare, the presence of excipients in different formulations can trigger allergic manifestations. We present an unusual case of delayed hypersensitivity reaction characterized by isolated asymmetric periorbital edema, occurring within 1 to 2 months of being on levothyroxine therapy.

Potential Protective Effect of Hepatitis B Immunity Against Diabetes Mellitus: A Retrospective Propensity-Matched Cohort Study.

: Hepatitis B virus (HBV) infection affects glucose metabolism and increases diabetes risk; HBV vaccination may reduce this risk. The role of HBV immunity in diabetes prevention among individuals without HBV infection is underexplored. This study aims to evaluate whether HBV immunity reduces diabetes risk in individuals without HBV infection.

Sacral Metastasis in Follicular Thyroid Carcinoma: Cytology Pitfalls and Serum Thyroglobulin Utility.

Sacral bone metastasis from primary follicular thyroid carcinoma (FTC) is rare. Most reported cases include factors indicative of thyroid origin, such as a history of treated thyroid cancer or newly identified thyroid nodules with malignant cytology. We herein report a 57-year-old woman with a metastatic sacral lesion of thyroid origin, initially misdiagnosed due to a false-negative fine-needle aspiration (FNA) cytology result of a thyroid nodule.

Revisiting Eosinophilia: A Neglected Indicator of Adrenal Insufficiency.

Diagnosing adrenal insufficiency is challenging due to its nonspecific symptoms and insidious onset. We report the case of a 55-year-old woman who developed persistent eosinophilia accompanied by nausea, vomiting, fatigue, muscle weakness, dizziness, and brain fog following her second COVID-19 vaccination. A comprehensive evaluation ultimately led to the diagnosis of adrenal insufficiency.

The H, N and C backbone resonance assignments of the N-terminal (1-149) domain of Serpine mRNA Binding Protein 1 (SERBP1).

Serpine mRNA-Binding Protein 1 (SERBP1) is an RNA-binding protein implicated in diverse cellular functions, including translational regulation, tumor progression, and stress response. It interacts with ribosomal subunits, RNA, and proteins involved in stress granules, contributing to processes such as phase separation and epigenetic regulation. Recent studies have shown SERBP1's role in glioblastoma progression and its involvement in ribosomal regulation.

Revolutionizing biological digital twins: Integrating internet of bio-nano things, convolutional neural networks, and federated learning.

Digital twins (DTs) are advancing biotechnology by providing digital models for drug discovery, digital health applications, and biological assets, including microorganisms. However, the hypothesis posits that implementing micro- and nanoscale DTs, especially for biological entities like bacteria, presents substantial challenges. These challenges stem from the complexities of data extraction, transmission, and computation, along with the necessity for a specialized Internet of Things (IoT) infrastructure.

Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells.

Natural products have long been a viable source of therapeutic agents, providing unique structures and mechanisms that may be beneficial for cancer treatment. Herein we first report on the anticancer activity OST-01, a natural product from Baccharis Coridifolia, on breast cancer cells, including triple-negative breast cancer (TNBC). OST-01 significantly inhibited cell proliferation and oncogenic activities of TNBC cells in vitro.

Expression and function of Connexin 43 and Connexin 37 in the murine zona glomerulosa.

The zona glomerulosa (ZG) synthesizes the mineralocorticoid aldosterone. The primary role of aldosterone is the maintenance of volume and electrolyte homeostasis. Aldosterone synthesis is primarily regulated via tightly controlled oscillations in intracellular calcium levels in response to stimulation.

Assessment of the Performance of the Dose Calibrator Used in Radioactivity Measurement.

Aims: This study aimed to evaluate the principal technical characteristics of a well-type gas-filled ionization chamber dose calibrator used in measuring radiopharmaceutical activity, namely accuracy, repeatability, and linearity. Furthermore, this work also explored the correlation between the device's response and the position and volume of the radiopharmaceutical I-131.

Materials And Methods: Experimental measurements were conducted on the ATOMLAB 500 dose calibrator using NIST traceable Cs-137 source to determine the accuracy and repeatability.

AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition.

Cytoplasmic proliferating cell nuclear antigen (PCNA) is highly expressed in acute myeloid leukemia (AML) cells, supporting oxidative metabolism and leukemia stem cell (LSC) growth. We report on AOH1996 (AOH), an oral compound targeting cancer-associated PCNA, which shows significant antileukemic activity. AOH inhibited growth in AML cell lines and primary CD34 + CD38 - blasts (LSC-enriched) in vitro while sparing normal hematopoietic stem cells (HSCs).

DetSegDiff: A joint periodontal landmark detection and segmentation in intraoral ultrasound using edge-enhanced diffusion-based network.

Individuals with malocclusion require an orthodontic diagnosis and treatment plan based on the severity of their condition. Assessing and monitoring changes in periodontal structures before, during, and after orthodontic procedures is crucial, and intraoral ultrasound (US) imaging has been shown a promising diagnostic tool in imaging periodontium. However, accurately delineating and analyzing periodontal structures in US videos is a challenging task for clinicians, as it is time-consuming and subject to interpretation errors.

Pregnancy in Infertile Patient after Intrauterine Adhesiolysis by Multitherapeutic Strategy: A Case Report and Mini-review.

Asherman's syndrome, characterized by intrauterine adhesions (IUAs), represents a significant challenge in the field of female infertility. Hysteroscopic adhesiolysis has emerged as the gold standard for both the diagnosis and treatment of Asherman's syndrome. Understanding the intricate relationship between Asherman's syndrome, uterine adhesiolysis, and infertility is crucial for guiding comprehensive and effective management strategies.

Homoharringtonine synergizes with venetoclax in early T cell progenitor acute lymphoblastic leukemia: Bench and bed.

Background: Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of T-ALL with a poor prognosis. To find a cure, we examined the synergistic effect of homoharringtonine (HHT) in combination with the BCL-2 inhibitor venetoclax (VEN) in ETP-ALL.

Methods: Using in vitro cellular assays and ETP-ALL xenograft models, we first investigated the synergistic activity of HHT and VEN in ETP-ALL.

Rescue extracranial vertebral stenting in tandem occlusions: A preliminary Vietnamese study.

Background And Purpose: The acute vertebrobasilar occlusion associated with the poor prognosis, particularly tandem occlusion. However, few data on the efficacy of the endovascular therapy was indicated in this occlusion. We investigated whether the additional rescue extracranial vertebral stenting improved clinical outcome by modified Rankin scale (mRS) score within 3 months after the procedure.

T- and L-Type Calcium Channels Maintain Calcium Oscillations in the Murine Zona Glomerulosa.

Background: The zona glomerulosa of the adrenal gland is responsible for the synthesis and release of the mineralocorticoid aldosterone. This steroid hormone regulates salt reabsorption in the kidney and blood pressure. The most important stimuli of aldosterone synthesis are the serum concentrations of angiotensin II and potassium.