Prognostic Value of a ≥ 1000 μm Posterior Margin After Gerota's Fascia Resection in Distal Pancreatectomy for Resectable Pancreatic Cancer: A Single-Center Retrospective Study.

Background: Radical antegrade modular pancreatosplenectomy (RAMPS) enables posterior dissection along Gerota's fascia, contributing to improved R0 resection rates, lymphadenectomy, and overall survival (OS) in pancreatic body and tail cancers. Although a posterior margin ≥ 1000 μm has been associated with better prognosis, its relative impact compared with Gerota's fascia resection remains unclear. This study evaluated whether securing a posterior margin ≥ 1000 μm improves outcomes in patients undergoing Gerota's fascia resection for pancreatic body and tail cancer.

Successful Left Bundle Branch Area Pacing Using the Sheath-In-Sheath Technique in a Patient With Right Atrial Enlargement and Tricuspid Annuloplasty Ring.

We report a successful LBBAP lead implantation using the sheath-in-sheath technique in a patient with RA enlargement and a TAP ring. The sheath-in-sheath technique can serve as a valuable alternative approach in patients with structural heart abnormalities in whom LBBAP lead placement with a standard delivery system is technically challenging.

Renal Transplantation in Relation to Positive T-cell Flow Cytometric Crossmatch: A Retrospective Study.

Background: Human leukocyte antigen antibodies play a significant role in kidney transplant rejection at all stages. Cross-matching and human leukocyte antigen antibody testing, especially in donor-specific antibody (DSA)-positive cases, are essential for reducing the risk of antibody-mediated rejection. Despite increasing numbers of DSA-positive transplants with desensitization therapy, guidelines for assessing transplant suitability and therapy selection remain undefined.

The variation in the amount of black carbon particles deposited on leaves at different positions in the canopy of mature Cornus florida and related factors.

In urban areas, black carbon (BC) particles with an aerodynamic diameter of 2.5 µm or less (PM) have adverse effects on human health. Urban greening is considered a potential solution to mitigate air pollution caused by BC particles, because atmospheric BC particles can be deposited and retained on the leaves of urban greening trees, resulting in a reduction in the atmospheric concentration of BC particles around the trees.

Char Formation During Very High-Power Short-Duration Ablation for Atrial Fibrillation.

Introduction: Pulmonary vein (PV) isolation using very high-power short-duration (vHPSD) radiofrequency catheter ablation is an effective treatment strategy for atrial fibrillation. However, PV isolation using vHPSD ablation (vHPSD-PVI) carries a potential risk of char formation. We aimed to assess the incidence, patient characteristics, and procedural factors of char formation during vHPSD-PVI.

Clinical Outcomes and Electrophysiological Characteristics of Partial Perforation After Left Bundle Branch Area Pacing.

Background: Septal perforation, defined as partial or complete protrusion of a lead helix, is a potential complication of left bundle branch area pacing, theoretically increasing risks of pacing failure and thromboembolism. However, no studies have examined the long-term prognosis of patients with partial perforations (PPs).

Objectives: This study aimed to elucidate the incidence, outcomes, and electrophysiological characteristics of PP in clinical and experimental swine studies.

Imaging phenotype reveals that disulfirams induce protein insolubility in the mitochondrial matrix.

The cell painting assay is useful for understanding cellular phenotypic changes and drug effects. To identify other aspects of well-known chemicals, we screened 258 compounds with the cell painting assay and focused on a mitochondrial punctate phenotype seen with disulfiram. To elucidate the reason for this punctate phenotype, we looked for clues by examining staining steps and gene knockdown as well as examining protein solubility and comparing cell lines.

Information structure of heterogeneous criticality in a fish school.

Integrated information theory (IIT) assesses the degree of consciousness in living organisms from an information-theoretic perspective. This theory can be generalised to other systems, including those exhibiting criticality. In this study, we applied IIT to the collective behaviour of Plecoglossus altivelis and observed that the group integrity (Φ) was maximised at the critical state.

Long-Term Outcomes in Patients With Relatively High His-Bundle Capture Threshold After Permanent His-Bundle Pacing - A Multicenter Clinical Study.

Background: Outcomes in patients with relatively high His-bundle (HB) capture thresholds at implantation are unknown. This study aimed to compare changes in the HB capture threshold and prognosis between patients with a relatively high threshold and those with a low threshold.

Methods And Results: Forty-nine patients who underwent permanent HB pacing (HBP) were divided into two groups: low (<1.

Robust spatial self-organization in crowds of asynchronous pedestrians.

Human crowds display various self-organized collective behaviours, such as the spontaneous formation of unidirectional lanes in bidirectional pedestrian flows. In addition, parts of pedestrians' footsteps are known to be spontaneously synchronized in one-dimensional, single-file crowds. However, footstep synchronization in crowds with more freedom of movement remains unclear.

Resection of a retroperitoneal lumbar vein aneurysm: A case report.

We present a rare case involving a 54-year-old man with a history of pancreatitis who developed a retroperitoneal lumbar vein aneurysm that was initially misidentified as a pancreatic pseudocyst. Subsequent imaging revealed an enlarged mass and retroperitoneal perforation. Despite initial hesitation, the patient eventually underwent radical surgery that enabled the successful removal of the mass, which was near the inferior vena cava.

Optimal ablation settings of TactiFlex SE laser-cut irrigated-tip catheter: comparison with ThermoCool SmartTouch SurroundFlow porous irrigated-tip catheter.

Background: The TactiFlex SE catheter (TFSE, Abbott) with a contact force (CF) sensor and a laser-cut irrigated-tip has recently become available but lacks a lesion quality marker. This study aimed to explore distinctions in lesion characteristics between the TFSE and the ThermoCool SmartTouch SurroundFlow catheter (STSF, Biosense Webster), which utilizes a porous irrigated tip, and to assess the most effective application settings for the TFSE.

Methods: Lesions were generated using varying settings of radiofrequency power (30-50 W), CF (10-20 g), application duration (10-40 s), and catheter orientation (perpendicular or parallel) in an ex vivo porcine model.

Relationship between the amount of black carbon particles deposited on the leaf surface and leaf surface traits in nine urban greening tree species.

To select urban greening tree species suitable for the purification of the atmosphere polluted by black carbon (BC) particles, it is necessary to clarify the determinants of the amount of BC particles deposited on the tree leaves. In the present study, we investigated the relationship between the amount of BC particles that were deposited from the atmosphere and firmly adhered to the leaf epicuticular wax, and leaf surface traits in seedlings of nine tree species grown for two years under natural conditions (Fuchu, Tokyo, Japan). There was a significant interspecific difference in the maximum amount of BC particles deposited on the leaf surface, and the order was as follows: > > > > ≒ > ≒ ≒ .

Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models.

The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator of cancer cell proliferation, survival, and invasion. We discovered YHO-1701 as a small molecule inhibitor of STAT3 dimerization and demonstrated its potent anti-tumor activity using xenograft mouse models as monotherapy and combination therapy with molecular targeted drugs. STAT3 is also associated with cancer immune tolerance; therefore, we used the female CT26 syngeneic mouse model to examine the effect of combining YHO-1701 administration with PD-1/PD-L1 blockade.

Functional duality in group criticality via ambiguous interactions.

Critical phenomena are wildly observed in living systems. If the system is at criticality, it can quickly transfer information and achieve optimal response to external stimuli. Especially, animal collective behavior has numerous critical properties, which are related to other research regions, such as the brain system.

Gallbladder cancer concomitant with autosomal dominant polycystic kidney disease: A case report.

The case is a 67-year-old female with autosomal dominant polycystic kidney disease who was followed up regularly. CT scan showed a mural nodule growing over the past 4 years inside the hypodense region surrounded by hepatic cysts. Surgery was performed and the pathological diagnosis was StageI gallbladder cancer.

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase.

Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are main enzymes regulating the first and rate-limiting step of the Kyn pathway. To identify new small molecule inhibitors of TDO, we selected A172 glioblastoma cell line constitutively expressed TDO.

Spontaneous behavioral coordination between avoiding pedestrians requires mutual anticipation rather than mutual gaze.

Pedestrians threading through a crowd is a striking example of coordinated actions. Mutual anticipation between pedestrians is a candidate mechanism underlying such coordination. To examine this possibility, we experimentally intervened pairs of pedestrians performing simple avoidance tasks.

Septal coronary artery fistula after left bundle branch area pacing assessed by multi-imaging modalities and shunt volume quantification.

Septal coronary artery fistula is a rare but concerning complication of left bundle branch area pacing (LBBAP). We report the case of an 82-year-old man who was indicated for cardiac resynchronization therapy and underwent LBBAP. The patient had no chest symptoms during or after implantation.

Permanent His-bundle pacing using distal His-bundle electrogram-guided approach in patients with atrioventricular block.

Background: Permanent His-bundle pacing (HBP) is effective and safe; however, the success rate of HBP is low, especially in patients with infranodal block. This study aimed to assess the efficacy and feasibility of HBP implantation using an electrophysiological guided approach targeting a distal His-bundle electrogram (HBE) in patients with atrioventricular block (AVB).

Methods: Thirty-four consecutive patients with AVB (infranodal block in 28 patients) who underwent HBP were enrolled.