Publications by authors named "Himangi Vig"
A Brief Review on Caenorhabditis elegans Role in Modelling Neurodegenerative Disease.
Cent Nerv Syst Agents Med Chem
October 2024
Article Synopsis
- C. elegans, a small, translucent nematode, is used as a model organism for biomedical research due to its simple structure and short life cycle, allowing insights into genetics, development, and aging.
- The worm has a nervous system with only 302 neurons, making it an ideal subject for studying age-related neurodegenerative diseases and their cellular processes.
- The review covers methodologies for using C. elegans in research and highlights its advantages, such as physiological transparency and a complete connectome, which aid in understanding neurodegeneration and developing therapeutic strategies.
Naringenin: A Promising Immunomodulator for Anti-inflammatory, Neuroprotective and Anti-cancer Applications.
Antiinflamm Antiallergy Agents Med Chem
April 2025
Article Synopsis
- Inflammatory, immune, and neurodegenerative diseases are prevalent worldwide, and naringenin, a natural compound, shows promise for therapy due to its multifaceted health benefits.
- This review highlights naringenin's mechanisms in reducing inflammation and protecting the immune system and nervous system, as well as its pharmacological targets and clinical study insights.
- Despite the substantial evidence supporting naringenin’s therapeutic potential, more in vivo studies are needed to facilitate its practical use in treatment.
Article Synopsis
- Aging and neurodegenerative diseases, like Parkinson's, are linked to mitochondrial dysfunction and free radical damage.
- Recent studies from 2014 to 2022 indicate that mitochondrial transplantation and targeted therapies show potential as treatments for Parkinson's by improving energy production and reducing oxidative stress.
- Optimizing mitochondrial dynamics may pave the way for new therapeutic approaches to slow neuronal cell death and delay neurodegenerative disease progression.
Background: Parkinson's disease is a complicated, gradually progressive neurological illness characterized by locomotor and non-motor symptomatology that impedes daily activities. Despite significant advances in symptomatic therapies with various extents of negative effects, there are currently no disease-modifying medicinal alternatives. Symptoms worsen, creating an additional strain that reduces living quality and creates the perception that prescription drugs are no longer productive.
View Article and Find Full Text PDFTreatment of Parkinson's Disease: Current Treatments and Recent Therapeutic Developments.
Curr Drug Discov Technol
August 2023
Background: Parkinson's disease (PD) is a neurodegenerative syndrome defined by a variety of motor, cognitive, and psychomotor dysfunctions. The current pharmaceutical treatment focuses on treating the condition's symptoms. They are primarily concerned with reducing illness symptoms or avoiding dopamine metabolism.
View Article and Find Full Text PDFBackground: The existence of aberrant myocardial activity and function in the exclusion of those other cardiovascular events, such as atherosclerosis, hypertension, and severe valve disease, is known as diabetic cardiomyopathy. Diabetes patients are much more prone to death from cardiovascular illnesses than from any other cause, and they also have a 2-5 fold higher likelihood of acquiring cardiac failure and other complications.
Objective: In this review, the pathophysiology of diabetic cardiomyopathy is discussed, with an emphasis on the molecular and cellular irregularities that arise as the condition progresses, as well as existing and prospective future treatments.
A Systematic Review of Various Screening Models as well as the Mechanisms Involved in Parkinson's Disease Screening Procedures.
Curr Rev Clin Exp Pharmacol
January 2024
Background: Parkinson's disease is the second most common neurological ailment. It is also known that it affects practically all other brain components, although only gradually. Animal models are mostly used to test the efficacy of treatment against a specific enzyme and aid in creating a new drug dose.
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