Publications by authors named "Henry Ordutowski"
Self-powered microfluidics presents a revolutionary approach to address the challenges of healthcare in decentralized and point-of-care settings where limited access to resources and infrastructure prevails or rapid clinical decision-making is critical. These microfluidic systems exploit physical and chemical phenomena, such as capillary forces and surface tension, to manipulate tiny volumes of fluids without the need for external power sources, making them cost-effective and highly portable. Recent technological advancements have demonstrated the ability to preprogram complex multistep liquid operations within the microfluidic circuit of these standalone systems, which enabled the integration of sensitive detection and readout principles.
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- Therapeutic drug monitoring (TDM) for adalimumab (ADM) is crucial to maintain treatment effectiveness, but current point-of-care (POC) testing solutions are insufficient.
- The authors developed a new microfluidic chip that can detect ADM from whole blood within 30 minutes using an easy, self-powered design that separates plasma and performs an ELISA.
- This technology not only enables TDM at POC but also shows potential for other diagnostic applications, including tests for infectious diseases.
Article Synopsis
- Advanced biological therapies like adalimumab (ADM) are effective but expensive and can lose effectiveness over time; therapeutic drug monitoring (TDM) is suggested to optimize dosing, although it often takes a long time to get results.* -
- This study introduces a novel ADM-sensor that integrates fiber optic surface plasmon resonance (FO-SPR) and self-powered microfluidics, allowing for quick ADM monitoring directly in a doctor's office.* -
- The developed biosensor detects ADM in plasma with a limit of detection of 0.35 μg/mL and provides results in under 12 minutes, showcasing significant potential for bedside monitoring of various drugs beyond ADM in the future.*
Rapid diagnostic testing at the site of the patient is essential when a fully equipped laboratory is not accessible. To maximize the impact of this approach, low-cost, disposable tests that require minimal user-interference and external equipment are desired. Fluid transport by capillary wicking removes the need for bulky ancillary equipment to actuate and control fluid flow.
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