Evaluation of the Effectiveness of Student Practice in a Surgical Skills Curriculum: A Prospective Study.

Objectives:  This study aims to evaluate the effectiveness of student practice in a surgical skills curriculum and their evolution during the process and, therefore, evaluate the relevance of training surgical skills in medical graduation.

Methods: The study design was prospective observational and analytical, the participants were fourth-year medical students from the Bahiana School of Medical Education and Public Health, and the sample size was 300. The sampling method used was a non-probability sampling method, and data collection was realized through a questionnaire in a QR code with a study overview and a pre-assessment and post-assessment survey link.

New thermoresistant polymorph from CO2 recrystallization of minocycline hydrochloride.

Purpose: To prepare and thoroughly characterize a new polymorph of the broad-spectrum antibiotic minocycline from its hydrochloride dehydrate salts.

Methods: The new minocycline hydrochloride polymorph was prepared by means of the antisolvent effect caused by carbon dioxide. Minocycline recrystallized as a red crystalline hydrochloride salt, starting from solutions or suspensions containing CO2 and ethanol under defined conditions of temperature, pressure and composition.

The importance of heat flow direction for reproducible and homogeneous freezing of bulk protein solutions.

Freezing is an important operation in biotherapeutics industry. However, water crystallization in solution, containing electrolytes, sugars and proteins, is difficult to control and usually leads to substantial spatial solute heterogeneity. Herein, we address the influence of the geometry of freezing direction (axial or radial) on the heterogeneity of the frozen matrix, in terms of local concentration of solutes and thermal history.

Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model.

Strangles is an extremely contagious and sometimes deadly disease of the Equidae. The development of an effective vaccine should constitute an important asset to eradicate this worldwide infectious disease. In this work, we address the development of a mucosal vaccine by using a Supercritical Enhanced Atomization (SEA) spray-drying technique.

Formation of indomethacin-saccharin cocrystals using supercritical fluid technology.

The main objective of the present work is to check the feasibility of supercritical fluid (SCF) technologies in the screening and design of cocrystals (novel crystalline solids). The cocrystal formation tendencies in three different SCF techniques, focusing on distinct supercritical fluid properties - solvent, anti-solvent and atomization enhancer - were investigated. The effect of processing parameters on the cocrystal formation behaviour and particle properties in these techniques was also studied.