Publications by authors named "Harita Desai"
Background: The inherent limitation of ocular dosage forms is decreased precorneal residence time which affects the bioavailability and therapeutic efficacy.
Objective: The objective of the current research was to sustain drug release and enhance precorneal drug residence time by formulating lipidic core-shell nanoparticles of Dexamethasone Sodium Phosphate and loading them in ion-sensitive in situ gel for corneal neovascularization.
Methods: Polymeric nanoparticles were formulated using Eudragit L100-55 and PVA by twostep solvent diffusión nanoprecipitation method and coated by a lipidic film of Soya phosphatidylcholine with Cholesterol.
Versatility of emulgel in topical drug delivery transforming its expedition from bench to bedside.
Expert Opin Drug Deliv
January 2025
Article Synopsis
- - Emulgel is a novel formulation that enhances drug stability and topical delivery by combining emulsion and gel, leading to better skin penetration and extended therapeutic effects.
- - The review discusses the commercial viability of emulgels, covering manufacturing strategies, characterization techniques, and an in-depth market analysis supported by recent case studies and research data from reputable sources.
- - Emulgels show potential for commercialization due to their effective drug delivery and user-friendly nature, but challenges like regulatory complexities need to be addressed for better market access and innovation in the future.
Anterior uveitis is one of the most prevalent forms of ocular inflammation caused by infections, trauma, and other idiopathic conditions if not treated properly, it can cause complete blindness. Therefore, this study aimed to formulate and evaluate dexamethasone sodium phosphate (DSP) loaded polyelectrolyte complex (PEC) nanoparticles (NPs) for the treatment of anterior uveitis. DSP-loaded PEC-NPs were formed through complex coacervation by mixing low molecular weight chitosan and the anionic polymer carboxy methyl cellulose (CMC).
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