Publications by authors named "Hai-Lin Xiong"
Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension.
Gastroenterology
October 2024
Background & Aims: Portal hypertension (PH) is one of the most frequent complications of chronic liver disease. The peripheral 5-hydroxytryptamine (5-HT) level was increased in cirrhotic patients. We aimed to elucidate the function and mechanism of 5-HT receptor 1A (HTR1A) in the portal vein (PV) on PH.
View Article and Find Full Text PDFColorectal cancer (CRC), the third most common cancer worldwide, poses a threat to human life. However, its underlying mechanism is unclear and no satisfactory treatment is available. The present study aimed to investigate the role of circular RNA argininosuccinate synthase 1 (circASS1) in CRC cells and tissues to identify the potential mechanism underlying the pathogenesis of CRC.
View Article and Find Full Text PDFArticle Synopsis
- MicroRNAs (miRNAs) are tiny RNA molecules that help control how genes work and play a big role in cancer treatment resistance.
- In a study, scientists found that a specific miRNA called miR-197 was less active in stomach cancer cells that didn't respond to a drug called 5-FU.
- When they increased miR-197 levels, the cancer cells became more sensitive to 5-FU, and they discovered that miR-197 works by blocking a gene called MAPK1.
Aberrant DNA methylation of P16, MGMT, hMLH1 and hMSH2 genes in combination with the MTHFR C677T genetic polymorphism in gastric cancer.
Asian Pac J Cancer Prev
October 2014
Associations of P16, MGMT, hMLH1 and hMLH2 with gastric cancer and their relation with MTHFR status in gastric patients who were confirmed with pathological diagnosis were assessed. Aberrant DNA methylation of P16, MGMT, hMLH1 and hMLH2 and polymorphisms of MTHFR C677T were assayed. The proportional DNA hypermethylation in P16, MGMT, hMLH1 and hMLH2 in cancer tissues was significantly higher than in remote normal-appearing tissues.
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