Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation.

Pancreatic ductal adenocarcinoma (PDAC), a lethal malignancy with difficult early diagnosis and poor prognosis, urgently requires elucidation of the molecular determinants dictating pancreatic cancer initiation and progression. Little is known about cingulin (CGN) in carcinogenesis. In this study, we demonstrated the critical oncogenic role of CGN in PDAC pathogenesis.

Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates.

Purpose: Pancreatic ductal adenocarcinoma (PDA) resists immunotherapy of adoptive cell transfer (ACT) and immune checkpoint inhibitors. Understanding the mechanisms underlying this resistance will improve PDA immunotherapy. This study investigated therapeutic effects and underlying mechanisms of anticoagulants on immunotherapy in PDA.