Publications by authors named "Guenda Meffe"
Aim: This observational analysis, derived from the prospective mono-institutional COMBART cohort (stage IV breast cancer patients undergoing radiation therapy during novel systemic treatments), evaluates the safety of combining radiotherapy (RT) with Trastuzumab Deruxtecan (T-DXd) in metastatic breast cancer patients.
Material And Methods: Patients eligible for this analysis received conventional RT or stereotactic radiotherapy (SRT) concurrently with T-DXd. RT was considered concurrent if administered on the same day as T-DXd or during the three-week interval between cycles.
Purpose: To train and validate KB prediction models by merging a large multi-institutional cohort of whole breast irradiation (WBI) plans using tangential fields.
Methods: Ten institutions (INST1-INST10, 1481 patients) developed their KB-institutional models for left/right WBI (ten models for right and eight models for left). The transferability of models among centers was assessed based on the overlap of the geometric Principal Component (PC1) of each model when applied to other institutions and/or on the presence of significantly different optimization policies.
Article Synopsis
- Splenomegaly is a common issue in patients with chronic blood cancers, and while splenectomy is effective, it poses significant risks; this study examines the use of magnetic resonance guided radiation therapy (MRgRT) as a treatment option.
- The study involved a retrospective analysis of 12 patients with myelofibrosis and myelodysplastic/myeloproliferative neoplasms who received targeted radiation to their spleens, resulting in pain relief and substantial reductions in spleen size.
- Findings suggest that MRgRT for splenic irradiation can be effective with minimal non-hematological side effects, but further research is necessary to confirm long-term efficacy and safety in larger populations.
Purpose: In radiotherapy it is often necessary to transfer a patient's DICOM (Digital Imaging and COmmunications in Medicine) dataset from one system to another for re-treatment, plan-summation or registration purposes. The aim of the study is to evaluate effects of dataset transfer between treatment planning systems.
Materials And Methods: Twenty-five patients treated in a 0.
Article Synopsis
- * A total of 16 new patients were analyzed to assess the variability in predicted dose-volume-histograms (DVH) for the heart and lungs, finding low inter-institutional variability with standard deviations of 1.8% for the ipsilateral lung and 1.6% for the heart.
- * The results indicated that the KB models were highly transferable with minimal differences, suggesting the potential for developing standard benchmark models for improving treatment consistency in TF-WBI.
Evaluation of clinical parallel workflow in online adaptive MR-guided Radiotherapy: A detailed assessment of treatment session times.
Tech Innov Patient Support Radiat Oncol
March 2024
Introduction: Advancements in MRI-guided radiotherapy (MRgRT) enable clinical parallel workflows (CPW) for online adaptive planning (oART), allowing medical physicists (MPs), physicians (MDs), and radiation therapists (RTTs) to perform their tasks simultaneously. This study evaluates the impact of this upgrade on the total treatment time by analyzing each step of the current 0.35T-MRgRT workflow.
View Article and Find Full Text PDFIntroduction: Patients treatment compliance increases during free-breathing (FB) treatment, taking generally less time and fatigue with respect to deep inspiration breath-hold (DIBH). This study quantifies the gross target volume (GTV) motion on cine-MRI of apical lung lesions undergoing a SBRT in a MR-Linac and supports the patient specific treatment gating pre-selection.
Material And Methods: A total of 12 patients were retrospectively enrolled in this study.
Introduction: Contouring of gas pockets is a time consuming step in the workflow of adaptive radiotherapy. We would like to better understand which gas pockets electronic densitiy should be used and the dosimetric impact on adaptive MRgRT treatment.
Materials And Methods: 21 CT scans of patients undergoing SBRT were retrospectively evaluated.
The accurate diagnosis of bone metastasis, a condition in which cancer cells have spread to the bone, is essential for optimal patient care and outcome. This review provides a detailed overview of the current medical imaging techniques used to detect and diagnose this critical condition focusing on three cardinal imaging modalities: positron emission tomography (PET), single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Each of these techniques has unique advantages: PET/CT combines functional imaging with anatomical imaging, allowing precise localization of metabolic abnormalities; the SPECT/CT offers a wider range of radiopharmaceuticals for visualizing specific receptors and metabolic pathways; MRI stands out for its unparalleled ability to produce high-resolution images of bone marrow structures.
View Article and Find Full Text PDFBackground: The THUNDER-2 phase II single institutional trial investigates the benefits of MRI-guided radiotherapy (MRIgRT) in treating locally advanced rectal cancer (LARC). This study focuses on evaluating the impact of escalating radiation therapy dose in non-responder patients using the Early Tumour Regression Index (ERI) for predicting complete response (CR). The trial's primary endpoint is to increase the CR rate in non-responders by 10% and assess the feasibility of the delta radiomics-based MRIgRT predictive model.
View Article and Find Full Text PDFBackground: Transarterial Radioembolization (TARE) is a widespread radiation therapy for unresectable hepatic lesions, but a clear understanding of the dose-response link is still missing. The aim of this preliminary study is to investigate the role of both dosimetric and clinical parameters as classifiers or predictors of response and survival for TARE in hepatic tumors and to present possible response cut-off.
Methods: 20 patients treated with glass or resin microspheres according to a personalized workflow were included.
Article Synopsis
- Interventional radiology workers face potential high exposure to ionizing radiation, emphasizing the need for accurate dose estimation to classify risks accurately.
- The study evaluates the accuracy of estimating the effective dose (ED) using measurable quantities like dose-area product (DAP) and fluoroscopy time (FT), by establishing correction factors (CF) specific to radiological units.
- Results showed that applying appropriate CFs significantly improved the accuracy of ED estimations from DAP and FT, suggesting that DAP provides a more conservative and straightforward method for dose estimation.