Comprehensive analysis of growth performance, antioxidant capacity, digestive enzyme activity, and transcriptomics provides insights into the chronic high-temperature stress response of brass gudgeon (Coreius heterodon) in the Yangtze River.

Global warming poses a serious threat to both wild and farmed fish. The brass gudgeon (Coreius heterodon) is a unique species of the Yangtze River and has important scientific value for studies of the impact of climate change. In this study, brass gudgeon were cultured for 40 days at 22 °C as control group, and at 27°C and 32°C as mild and severe high-temperature groups, respectively.

Eriocheir sinensis CD63 activate mitochondria-mediated apoptosis to resist Spiroplasma eriocheiris infection.

CD63, a member of the tetraspanins, is involved in cell movement, adhesion, immune response. Nevertheless, the role of CD63 in combating pathogen infections in invertebrates remains largely unclear. Tremor disease, whose pathogen is Spiroplasma eriocheiris, is one of the most prevalent illnesses affecting Eriocheir sinensis.

Crab microRNA-381-5p regulates prophenoloxidase activation and phagocytosis to promote intracellular bacteria Spiroplasma eriocheiris infection by targeting mannose-binding protein.

Mannose-binding lectin plays an essential role in bacteria or virus-triggered immune response in mammals. Previous proteomic data revealed that in Eriocheir sinensis, the mannose-binding protein was differentially expressed after Spiroplasma eriocheiris infection. However, the function of mannose-binding protein against pathogen infection in invertebrates is poorly understood.

Screening for the Biomarkers Associated with Myocardial Infarction by Bioinformatics Analysis.

We aimed to find novel biomarkers associated with myocardial infarction (MI). The array data of GSE62646 were downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) were analyzed with limma package.

miR‑148 family members are putative biomarkers for sepsis.

Sepsis is a type of systemic inflammatory response caused by infection. The present study aimed to identify novel targets for the treatment of sepsis. We conducted bioinformatic analysis of the microarray Gene Expression Omnibus dataset GSE12624, which includes data on 34 patients with sepsis and 36 healthy individuals without sepsis.