Aptamer-functionalized magnetic covalent organic frameworks for rapid extraction and LC-MS/MS quantification of gentamicin in milk.

Gentamicin (GEN) residues in food products, arising from its extensive use in veterinary medicine, have prompted stringent regulations and a demand for simple, rapid detection methods. In this study, aptamer-modified magnetic covalent organic frameworks (COFs), denoted as TpDBD@Fe₃O₄@apt, were synthesized and employed as adsorbents in magnetic solid-phase extraction (MSPE) for the highly specific capture and enrichment of GEN residues in milk. Several factors influencing MSPE efficiency were systematically evaluated and optimized.

Virtual Screening Combined with Phase Transition-FRET for Discovery of Small-Molecule FcRn Antagonists.

Neonatal Fc receptor (FcRn) antagonists, which competitively block the binding of immunoglobulin G (IgG) to FcRn, offer a promising therapeutic strategy for treating IgG-mediated autoimmune disorders. However, all currently available FcRn antagonists are macromolecular therapeutic antibodies, which come with certain clinical limitations. The development of alternative small-molecule FcRn antagonists is therefore of considerable importance.

Nanomaterial-based magnetic solid-phase extraction in pharmaceutical and biomedical analysis.

Magnetic solid-phase extraction (MSPE) holds significant scientific and technological interest as a novel sample preparation method for complex samples due to its easy operation, swift separation, high adsorption efficiency, and environmental friendliness. As the core of MSPE, magnetic sorbents have captured tremendous attention in recent years. Various promising nanomaterials, such as metal-organic frameworks and covalent organic frameworks, have been synthesized and utilized as sorbents in pharmaceutical and biomedical analysis.