Publications by authors named "Giulia Vietti"
Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP).
Part Fibre Toxicol
February 2016
Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, not clearly elucidated. The purpose of the present review was to analyze the key events involved in the lung fibrotic reaction induced by CNT and to assess their relationships.
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- Carbon nanotubes (CNT) can cause lung problems in animals, including inflammation and scarring.
- The study found that these CNTs work through other cells to make lung fibroblasts grow and change, rather than affecting them directly.
- Using different tests, researchers discovered that CNTs help fibroblasts multiply by interacting with certain signaling pathways and growth factors in the body.
Inhalation is the main pathway of ZnO exposure in the occupational environment but only few studies have addressed toxic effects after pulmonary exposure to ZnO nanoparticles (NP). Here we present results from three studies of pulmonary exposure and toxicity of ZnO NP in mice. The studies were prematurely terminated because interim results unexpectedly showed severe pulmonary toxicity.
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View Article and Find Full Text PDFArticle Synopsis
- Carbon nanotubes (CNT) can cause lung problems and make certain cells in the lungs grow too much, which leads to fibrosis (scarring).
- Researchers tested different types of CNT and asbestos to see how they affected lung cells in labs (in vitro) and in mice (in vivo).
- They found that some CNT made lung cells grow faster and caused lung scarring, while other types of CNT did not have the same effect, showing that the structure of the CNT is important for their impact on lungs.