Structural and functional adaptations of human cardiomyocytes in metabolic disease and heart failure.

Heart failure (HF), obesity, and diabetes are associated with structural and functional changes that affect the heart at both the organ and cellular levels. Studying isolated adult single cardiomyocytes provides valuable mechanistic insights. However, isolating single cardiomyocytes from human tissue is particularly challenging.

Rabconnectin-3α/DMXL2 Is Locally Enriched at the Synaptic Ribbon of Rod Photoreceptor Synapses.

Ribbon synapses reliably transmit synaptic signals over a broad signalling range. Rod photoreceptor ribbon synapses are capable of transmitting signals generated by the absorption of single photons. The high precision of ribbon synapses emphasizes the need for particularly efficient signalling mechanisms.

CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets.

Background: Altered intracellular Ca homeostasis in neonatal platelets has been previously reported. This study aims to examine the changes in the Ca entry through the store-operated calcium entry (SOCE) mechanism in neonatal platelets.

Methods: Human platelets from either control women, mothers, and neonates were isolated and, following, were fixed after being treated as required.

Effects of Telmisartan, an AT1 receptor antagonist, on mitochondria-specific genes expression in a mouse MPTP model of Parkinsonism.

: Mitochondrial dysfunction plays a crucial role in Parkinson's disease (PD) pathogenesis. The present study was undertaken to investigate the effects of Telmisartan (TEL), an angiotensin II type 1 receptor (AT1R) blocker, on the mitochondria-specific genes expression in a mouse model of Parkinsonism. : Mice were divided into 5 groups with 6 in each; Group I received 0.

A short isoform of STIM1 confers frequency-dependent synaptic enhancement.

Store-operated Ca-entry (SOCE) regulates basal and receptor-triggered Ca signaling with STIM proteins sensing the endoplasmic reticulum (ER) Ca content and triggering Ca entry by gating Orai channels. Although crucial for immune cells, STIM1's role in neuronal Ca homeostasis is controversial. Here, we characterize a splice variant, STIM1B, which shows exclusive neuronal expression and protein content surpassing conventional STIM1 in cerebellum and of significant abundance in other brain regions.

Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system.

Phosphodiesterase-4 (PDE-4) inhibitors promote memory by blocking the degradation of cAMP. Existing evidence also shows that neuronal survival and plasticity are dependent on the phosphorylation of cAMP-response element-binding protein. In this regard, PDE-4 inhibitors have also been shown to reverse pharmacologically and genetically induced memory impairment in animal models.