Publications by authors named "Geunyeol Jeong"
Control of Overly Secreted Tryptophanyl tRNA Synthetase Attenuates Sepsis Severity in a Porcine Model.
Biomol Ther (Seoul)
September 2025
Sepsis is a leading cause of mortality in hospitals with a lack of reliable biomarkers and specialized therapeutics. Recently, highly secreted tryptophanyl-tRNA synthetase 1 (WARS1), an endogenous ligand for Toll-like receptor (TLR) 2 and TLR4, was found to be a potential theranostic target for hypercytokinemic severe sepsis. In this study, using the minipig sepsis model inoculated with cecum slurry, we demonstrated that increases in WARS1 levels were associated with severity of sepsis and showed strong correlations with RBC count and the levels of HGB, HCT, EPO, lactate, and PLT count in the acute phase of sepsis.
View Article and Find Full Text PDFSecondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (sHLH/MAS) is a life-threatening immune disorder triggered by rheumatic disease, infections, malignancies, or medications. Characterized by the presence of hemophagocytic macrophages and a fulminant cytokine storm, sHLH/MAS leads to hyperferritinemia and multiorgan failure and rapidly progresses to death. The high mortality rate and the lack of specific treatments necessitate the development of a new drug.
View Article and Find Full Text PDFArticle Synopsis
- Despite advancements in medicine, sepsis continues to have a high mortality rate due to a lack of effective biomarkers for diagnosis and treatment guidance.
- High levels of WARS1, a protein associated with inflammation, are linked to early death in critically ill sepsis patients, indicating its role in disease severity.
- An experimental antibody that neutralizes WARS1 has shown promise in reducing inflammation and improving survival rates in severely septic mice, suggesting a new potential treatment strategy for sepsis.