Publications by authors named "Hee Kyeong Yoon"
Article Synopsis
- Despite advancements in medicine, sepsis continues to have a high mortality rate due to a lack of effective biomarkers for diagnosis and treatment guidance.
- High levels of WARS1, a protein associated with inflammation, are linked to early death in critically ill sepsis patients, indicating its role in disease severity.
- An experimental antibody that neutralizes WARS1 has shown promise in reducing inflammation and improving survival rates in severely septic mice, suggesting a new potential treatment strategy for sepsis.
Tryptophanyl-tRNA Synthetase 1 Signals Activate TREM-1 via TLR2 and TLR4.
Biomolecules
September 2020
Tryptophanyl-tRNA synthetase 1 (WARS1) is an endogenous ligand of mammalian Toll-like receptors (TLR) 2 and TLR4. Microarray data, using mRNA from WARS1-treated human peripheral blood mononuclear cells (PBMCs), had indicated WARS1 to mainly activate innate inflammatory responses. However, exact molecular mechanism remains to be understood.
View Article and Find Full Text PDF