Malignancy risk associated with radioactive iodine therapy for Graves' disease.

Background: Radioactive iodine therapy (RAI) is a frequently chosen therapy for Graves' disease. The aim of this study was to determine whether RAI for Graves' disease increases the risk of thyroid malignancy.

Methods: A retrospective analysis was performed of all Graves' disease patients who underwent thyroidectomy at a single institution between 2013 and 2022.

Incidental Ga-DOTATATE uptake in thyroid nodules: Is guideline-directed management still appropriate?

Background: Fluorodeoxyglucose uptake on positron emission tomography imaging has been shown to be an independent risk factor for malignancy in thyroid nodules. More recently, a new positron emission tomography radiotracer-Gallium-68 DOTATATE-has gained popularity as a sensitive method to detect neuroendocrine tumors. With greater availability of this imaging, incidental Gallium-68 DOTATATE uptake in the thyroid gland has increased.

Massive 4-Gland Parathyroid Hyperplasia Initially Detected as a Parathyroid Adenoma.

Parathyroid adenoma (PA) and parathyroid hyperplasia (PH) are common causes of primary hyperparathyroidism (PHPT), for which the only definitive treatment is surgery. Abnormalities in the parathyroid glands can be identified with various imaging modalities including ultrasound (US), sestamibi scan (MIBI), 4-dimensional computed tomography (4D-CT), and positron emission tomography/computed tomography (PET/CT). While it is not uncommon for parathyroid pathology to be undetected on imaging, this is more typical of low-volume hyperplasia and smaller-sized adenomas.

Utility of Thyroid Function Testing in the Inpatient Setting.

Objective: Previous studies have reported a low value of ordering inpatient thyroid function tests (TFTs), with few changes in clinical management resulting from these tests. This study was designed to evaluate how often testing the thyroid function during hospitalization leads to medication initiation or adjustment and to determine whether the frequency of medication initiation or adjustment differs based on the indication for testing.

Methods: This is a retrospective observational study of 2278 patients who underwent TFTs tested while admitted to an academic hospital during a 5-month period.

Correlation of Hemoglobin A1C and Outcomes in Patients Hospitalized With COVID-19.

Objective: Diabetes is a known risk factor for severe coronavirus disease 2019 (COVID-19). We conducted this study to determine if there is a correlation between hemoglobin A1C (HbA1C) level and poor outcomes in hospitalized patients with diabetes and COVID-19.

Methods: This is a retrospective, single-center, observational study of patients with diabetes (defined by an HbA1C level of ≥6.

THYROTOXIC PERIODIC PARALYSIS IN A COMPETITIVE BODYBUILDER WITH THYROTOXICOSIS FACTITIA.

Objective: We report a case of thyrotoxic periodic paralysis (TPP) in a bodybuilder who developed paralysis secondary to thyrotoxicosis factitia after taking a supplement containing thyroid hormone. Interestingly, the patient had no intrinsic thyroid disease. Prompt recognition of thyrotoxicosis is critical to avoid progression of paralysis and subsequent complications.

ISOLATED PARAGANGLIOMA IN A PATIENT WITH MUTATION.

Objective: Paragangliomas (PGLs) are one of the many neoplasms associated with von Hippel-Lindau (VHL) disease. VHL disease type 2C is a unique subtype characterized by the presence of a PGL or pheochromocytoma without other VHL-associated neoplasms. This report describes a rare germline mutation in the gene in a patient with isolated PGL.

Nonautoimmune Hyperthyroidism Caused by a Somatic Mosaic Mutation Involving Part of the Thyroid Gland.

Nonautoimmune hyperthyroidism caused by activating mutations in the gene is a rare condition. In this study, we report a five-year-old girl diagnosed with nonautoimmune hyperthyroidism and tall stature harboring a somatic mosaic gain-of-function mutation in the gene (NM_080425.3: c.

Low Free T Is Associated With Worse Outcomes in Patients in the ICU Requiring Invasive Mechanical Ventilation.

Objective: Critical illness causes a decrease in serum free triiodothyronine (T) levels. This condition, known as nonthyroidal illness syndrome (NTIS), is associated with poor outcomes. The association of NTIS and outcomes in patients in the intensive care unit (ICU) requiring mechanical ventilation has not been well studied.

Method of detection of thyroid nodules: correlation with frequency of fine-needle aspiration and malignancy rate.

Background: Thyroid nodules are commonly found by screening, and the clinical implications are unclear.

Methods: We retrospectively studied 460 patients who were evaluated for thyroid nodules. Medical records were queried to determine how the nodules were detected.

Usefulness of Serum Triiodothyronine (T3) to Predict Outcomes in Patients Hospitalized With Acute Heart Failure.

Thyroid hormone plays an important role in cardiac function. Low levels of serum triiodothyronine (T) due to nonthyroidal illness syndrome may have adverse effects in heart failure (HF). This study was designed to assess the ability of T to predict in-hospital outcomes in patients with acute HF.

Evaluation of surgical outcomes and gallbladder characteristics in patients with biliary dyskinesia.

Introduction: This study was designed to compare symptomatic outcomes following cholecystectomy in patients with biliary dyskinesia.

Materials And Methods: From 1999 to 2006 at New York University Medical Center, 197 adults underwent hepatobiliary scintigraphy with cholecystokinin administration to evaluate gallbladder ejection fraction (GBEF). Biliary dyskinesia was demonstrated in 120 patients based on decreased GBEF of View Article and Find Full Text PDF