Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians.

Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100-104 years). Exercise downregulated 52 proteins (e.

The 'autoimmunome' of centenarians.

Objective: To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians.

Methods: We conducted data mining of previously published proteomic results using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and PHENOPEDIA databases.

Results: Sixteen autoimmune disease-related proteins were identified within the proteomic signatures of centenarians.

Psychological resilience, athletic experience, and competitive level of judokas. A transversal study.

Introduction: While there is agreement on the positive link between psychological resilience and athletic performance, conclusive findings regarding the association between psychological resilience and other variables of interest (for example, age, gender, type of sport, or competitive level) remain elusive.

Objective: The study aimed to assess psychological resilience levels among judokas and explore potential associations with demographic factors, judo experience and competitive level.

Methods: A total of 702 judokas (469 men and 233 women) participated in the study, of whom 194 (27.

Emotional Intelligence in Spanish Elite Athletes: Is There a Differential Factor between Sports?

Emotional intelligence is a determinant factor in sports performance. The present study analysed differences in total emotional intelligence and its four dimensions in 2166 Spanish athletes (25.20 ± 10.

Exercise effects on functional capacity and quality of life in older patients with colorectal cancer: study protocol for the ECOOL randomized controlled trial.

Background: Surgery and treatment for colorectal cancer (CRC) in the elderly patient increase the risk of developing post-operative complications, losing functional independence, and worsening health-related quality of life (HRQoL). There is a lack of high-quality randomized controlled trials evaluating the potential benefit of exercise as a countermeasure. The primary aim of this study is to evaluate the effectiveness of a home-based multicomponent exercise program for improving HRQoL and functional capacity in older adults undergoing CRC surgery and treatment.

Physical Activity and Mental Health in Undergraduate Students.

Most research support positive relationships between physical activity and mental health. However, possible moderating variables of these relationships have also been identified, such as age, gender, level of physical activity, and the scope of physical activity. This study aimed to analyze the relationships between physical activity and mental health levels in undergraduate students, assessing whether these associations can change depending on the level of physical activity (low, medium, or high) and the setting (occupational, commuting, or leisure time physical activity) in which it was performed.

Emotional Intelligence in Physical Activity, Sports and Judo: A Global Approach.

Emotional intelligence (EI) has been studied in relation to health and physical activity (PA) or in a sport-specific approach. EI is related to sports performance; however, combat sports seem to show characteristics of their own that involve better control of emotions than other sports. This study aimed to analyse whether there are differences in EI dimensions between those who do not achieve World Health Organization (WHO) PA recommendations, those who meet WHO PA recommendations, those who meet WHO PA recommendations practising sports, and judokas of different levels.

Resilience in Sports: Sport Type, Gender, Age and Sport Level Differences.

There seems to be a broad consensus that there is a positive correlation between resilience and sport performance. However, different studies show divergent results on the role played by certain variables in this relationship. This study aimed to analyze the possible relationships between resilience levels and the practiced sport according to gender, age, and competitive level of the athletes in 1047 competitive athletes from five different sports (handball, basketball, volleyball, athletics, and judo).

Emotional Intelligence of Undergraduate Athletes: The Role of Sports Experience.

Sport is an emotional experience. Studies have shown that high emotional intelligence (EI) is associated with better sports performance, though different aspects of sports experience and their relationship with EI are still unclear. This study examined the possible relationships between sports experience and EI dimensions of undergraduate athletes.

Heart Rate Variability and Exceptional Longevity.

Centenarians are the paradigm of human extreme longevity and healthy aging, because they have postponed, if not avoided, mayor age-related diseases. The purpose of this study was to investigate potential differences in resting heart rate variability (HRV) between young adults, octogenarians, and centenarians and assess whether HRV variables are predictors of all-cause mortality in centenarians. To this end, three groups of participants: young adults ( = 20; 20.

Individual Responsiveness to Physical Exercise Intervention in Acutely Hospitalized Older Adults.

We analyzed inter-individual variability in response to exercise among acutely hospitalized oldest-old adults. In this ancillary analysis of a randomized controlled trial, 268 patients (mean age 88 years) were assigned to a control (n = 125, usual care) or intervention group (n = 143, supervised exercise, i.e.

Effect of a Simple Exercise Program on Hospitalization-Associated Disability in Older Patients: A Randomized Controlled Trial.

Objective: Hospitalization-associated disability [HAD, ie, the loss of ability to perform ≥1 basic activities of daily living (ADLs) independently at discharge] is a frequent condition among older patients. The present study assessed whether a simple inpatient exercise program decreases HAD incidence in acutely hospitalized very old patients.

Design: In this randomized controlled trial (Activity in Geriatric Acute Care) participants were assigned to a control or intervention group and were assessed at baseline, admission, discharge, and 3 months thereafter.

Physical activity and emotional intelligence among undergraduate students: a correlational study.

Background: Physical activity (PA) can be a mechanism that develops emotions. Emotional intelligence (EI) is related to significant public health and psychological benefits. However, there is little information about the relationships between PA and EI dimensions: emotional attention, clarity, and repair.

Physical Activity among Spanish Undergraduate Students: A Descriptive Correlational Study.

Achieving the recommended levels of physical activity (PA) is associated with better health. Despite this, most undergraduate students report low levels of PA. This study aimed to assess the achievement of recommended PA levels in a wide sample of undergraduate students from Madrid ( = 2960).

Physical Activity and Sedentary Behavior at the End of the Human Lifespan.

To objectively assess physical activity levels and sedentary behavior in a cohort of Spanish centenarians and their nonagenarian peers. Physical activity and sedentary behavior patterns were objectively measured by an ActiGraph GT3X accelerometer in centenarians ( = 18; 83% women; 100.8 ± 0.

Health Benefits of an Innovative Exercise Program for Mitochondrial Disorders.

Purpose: We determined the effects of an innovative 8-wk exercise intervention (aerobic, resistance, and inspiratory muscle training) for patients with mitochondrial disease.

Methods: Several end points were assessed in 12 patients (19-59 yr, 4 women) at pretraining, posttraining, and after 4-wk detraining: aerobic power, muscle strength/power and maximal inspiratory pressure (main end points), ability to perform activities of daily living, body composition, quality of life, and blood myokines (secondary end points).

Results: The program was safe, with patients' adherence being 94% ± 5%.

Perceived environment in relation to objective and self-reported physical activity in Spanish youth. The UP&DOWN study.

The aims of the present study were to assess the association of environmental perception with objective and self-reported physical activity (PA) and the relation between environmental perception and meeting PA recommendations on children and adolescents. A sample of 1520 youth (770 boys) aged 8-18 years (12.1 ± 2.

Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828.

There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e.

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs.

Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e.

Reliability and validity of an adapted version of the ALPHA environmental questionnaire on physical activity in Spanish youth.

Introduction: Previous studies suggest that the physical environment is associated with youth physical activity levels.

Objective: The present study aimed at assessing the reliability and validity of an adapted version of the ALPHA environmental questionnaire (short version) to adults for application with Spanish youth.

Methods: The reliability was evaluated in a sample (n = 190, 80 girls, 14.

Prevalence of leisure-time sedentary behaviour and sociodemographic correlates: a cross-sectional study in Spanish adults.

Background: Being physically inactive has been linked to a higher mortality and poorer quality of life. This cross-sectional study examines the prevalence of leisure-time sedentary behaviour in a population of Spanish adults and its correlates with several sociodemographic variables.

Methods: Data were collected from 1,330 subjects living in Madrid (age: 18-65 years, 51.

ApoE gene and exceptional longevity: Insights from three independent cohorts.

The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine, using a case-control design, if the ApoE gene is associated with EL. We compared ApoE allele/genotype frequencies among the following cohorts: cases (centenarians, most with 1+ major disease condition; n=163, 100-111years) and healthy controls (n=1039, 20-85years) from Spain; disease-free cases (centenarians; n=79, 100-104years) and healthy controls (n=597, age 27-81years) from Italy; and cases (centenarians and semi-supercentenarians, most with 1+ major disease condition; n=729, 100-116years) and healthy controls (n=498, 23-59years) from Japan.

The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts.

The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n = 152, 128 women, 100-111 years; healthy controls: n = 343, 212 women, age <50 years; CAD controls: n = 98, 32 women, age ≤65 years) and Japanese (centenarians: n = 742, 623 women, 100-115 years; healthy controls: n = 920, 511 women, < 60 years; CAD controls: n = 395, 45 women, age ≤65 years).