Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis.

Background And Aims: During diabetic ketoacidosis (DKA), muscle tissue develops a profound insulin resistance that complicates reversal of this potentially lethal condition. We have investigated mediators of insulin action in human skeletal muscle during total insulin withdrawal in patients with type 1 diabetes, under the hypothesis that initial phases of DKA are associated with impaired postreceptor signaling.

Materials And Methods: Muscle biopsies were obtained during a randomized, controlled, crossover trial involving 9 patients with type 1 diabetes.