Publications by authors named "Francois Cornelis"

Purpose: This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption.

Materials And Methods: Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993-2025) using the keyword "cryoneurolysis." Statistical analyses included Mann-Kendall trend tests, Portmanteau white noise tests, Dickey-Fuller unit root tests, and Spearman correlations.

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Interventional neuro-oncology is an evolving subspecialty that leverages minimally invasive endovascular and percutaneous techniques to improve outcomes for patients with spine, brain, and head-neck tumours. While conventional interventions have historically focused on vascular pathologies such as stroke and aneurysms, interventional techniques in oncology are gaining prominence. This review explores the role of image-guided interventions in preoperative tumour embolization, middle meningeal artery embolization in thrombocytopenic cancer patients, management of head and neck hemorrhage, intra-arterial drug delivery, and spinal interventions.

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Objective: To assess the prognostic factors for clinical and radiological responses to percutaneous image-guided cryoablation (CA) in treating venous malformation (VM) and fibro-adipose vascular anomaly (FAVA).

Materials And Methods: Fifty-five patients (12 males, 43 females; median age: 30 years) with symptomatic lesions (median VAS pain score: 70; median initial volume: 12.2 mm³) underwent CA between 2012 and 2023.

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Purpose: Navigation and robotic systems aim to improve the accuracy and efficiency of percutaneous image-guided interventions, but the evaluation of their autonomy and integration of advanced imaging and artificial intelligence (AI) is lacking. The purpose of this study was to evaluate the level of automation and integration of advanced imaging and artificial intelligence in navigation and robotic systems for percutaneous image-guided interventions, using established and novel metrics to categorize and compare their capabilities.

Materials And Methods: Following PRISMA guidelines, a systematic review was conducted to identify studies on clinically validated navigation and robotic systems published between 2000 and May 2024.

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 To assess the feasibility and safety of cone-beam computed tomography (CBCT) advanced navigation for optimizing intra-arterial chemotherapy infusion (IACI) in patients with skull base tumors.  Retrospective review on 10 consecutive IACI procedures performed in five patients (four women, 1 man) over a 1-year period. The median age of the patients was 71 years (interquartile range: 34-74).

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Purpose: To determine the technical feasibility of discriminating discontiguous from contiguous ablation zones between a pair of microwave ablation (MWA) applicators using broadband microwave transmission signal measurements in an in vivo porcine liver model.

Materials And Methods: Dual applicator 2.45 GHz MWA was performed using 1 directional and 1 omnidirectional applicator, spaced 3 cm apart, under imaging guidance.

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Interventional radiology (IR) has aided advances in the diagnosis and treatment of lung pathologies through procedures such as percutaneous biopsy, tumor ablation and drainage of intra-thoracic collections. The success and safety of these interventions largely depend on timely and accurate needle/device placement. Additionally, there is an inherent need to minimize radiation exposure during image-guided procedures.

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In most of the cases Interventional Radiology techniques and therapies are proposed for the management of symptomatic soft tissue benign tumors responsible for pain and/or compression symptoms aiming to offer a curative intent by means of tumor necrosis with subsequent symptoms' management and improvement of life quality. The ablative therapies include chemical, thermal and non-thermal approaches while, trans-arterial (chemo)embolization also has a distinct role. Adjunct ancillary techniques should be performed whenever necessary to increase efficacy and safety and avoid or reduce complications.

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Microwave ablation often involves the use of continuous energy-delivery protocols with a fixed power and time. To achieve larger ablation zones, a range of protocols and power levels have been studied in experimental studies. The objective of the present study was to develop and experimentally evaluate the performance of a coupled computational electromagnetic-bioheat transfer model of 2.

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Purpose: To investigate over 10 years the safety and efficacy of percutaneous cryoablation for the treatment of abdominal wall endometriosis (AWE).

Methods: A systematic review was conducted of literature published between March 2014 and March 2024. Inclusion criteria focused on treatment efficacy studies, while exclusion criteria targeted case reports and studies lacking pertinent outcome data.

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Background: Percutaneous cryoablation (PCA), having shown effectiveness in treating liver, lung, prostate, breast, and kidney tumors, is now gaining attention for the treatment of soft tissue tumors. PCA functions by freezing tissue, which induces ice crystal formation and cell death without damaging collagen structures. Technical considerations include the selection and handling of cryoprobes and cryogenic agents, procedural duration, and choice of image guidance for precision.

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In tandem with the ever-increasing global population, the demand for diagnostic radiology service provision is on the rise and at a disproportionate rate compared to the number of radiologists available to practice. The current "revolution in robotics" promises to alleviate personnel shortages in many sectors of industry, including medicine. Despite negative depictions of robots in popular culture, their multiple potential benefits cannot be overlooked, in particular when it comes to health service provision.

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The advent of robotic systems in interventional radiology marks a significant evolution in minimally invasive medical procedures, offering enhanced precision, safety, and efficiency. This review comprehensively analyzes the current state and applications of robotic system usage in interventional radiology, which can be particularly helpful for complex procedures and in challenging anatomical regions. Robotic systems can improve the accuracy of interventions like microwave ablation, radiofrequency ablation, and irreversible electroporation.

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Purpose: To evaluate the safety and effectiveness of lateral or posterolateral percutaneous vertebroplasty (PVP) of osteolytic C1-C2 lesions performed under computed tomography (CT) guidance and local anesthesia.

Materials And Methods: A retrospective study of 16 consecutive patients (11 females and 5 males; aged from 24 to 86 years; median age, 65.5 years) who underwent 17 lateral or posterolateral PVP was performed.

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In the current study, a 3D finite element study was performed to investigate the biomechanical response of an osteoporotic spine segment treated with a novel transpedicular implant (V-STRUT, Hyprevention, France) made of PEEK (polyetheretherketone) material combined with either injections of 2, 3, 4, 5 and 6 cc of cement. The objective was to assess numerically the biomechanical performance of the implant in combination with different doses of the injected bone cement and to compare its performance with the gold standard vertebroplasty (VP) technique. A female (69 yo) was selected and a 3D finite element model of an osteoporotic spine segment was built based on a Computed Tomography (CT) scan performed from T12 to L2 with corresponding intervertebral discs and ligaments.

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Article Synopsis
  • This review examines various surgical and nonsurgical treatments for abdominal wall endometriosis to clarify optimal care options due to existing clinical uncertainty.* -
  • A total of 51 articles were analyzed, involving 2674 patients, showing that surgical methods had the best local tumor control and pain relief, with a median local tumor control rate of 100%.* -
  • Minor adverse events occurred in 17.5% of surgical cases and up to 76.4% with high-intensity focused ultrasound (HIFU), while severe adverse events were noted in 25 surgical patients.*
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Article Synopsis
  • - Pancreatic cancer is a leading cause of cancer-related deaths in the U.S., with a notably low 5-year survival rate of just 11%, and cryoablation is being explored as a promising treatment option for both locally advanced and metastatic cases.
  • - A case study discusses a 47-year-old woman with pancreatic cancer who underwent multiple treatments including a Whipple procedure, chemotherapy, and ultimately, palliative cryoablation for symptom relief.
  • - Post-cryoablation, the patient developed rare disseminated intravascular coagulation (DIC), leading to severe complications despite treatments, including multiple blood transfusions and intensive care management, indicating the risks associated with this emerging therapy.
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Article Synopsis
  • - Rheumatoid arthritis (RA) is a chronic autoimmune disease influenced by genetic and environmental factors, with rare genetic variants potentially contributing to its development.
  • - Researchers identified rare genetic variants linked to RA using whole-exome sequencing in French families, focusing on a significant pathway related to cell adhesion.
  • - The study utilized a multifactor dimensionality reduction approach to discover gene interactions affecting RA risk, highlighting 11 genes with both risk-increasing and risk-decreasing interactions confirmed in additional samples.
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