Coacervate Vesicles as Adaptive Platforms for Synthetic Biology and Smart Materials.

Coacervate vesicles represent a versatile and emerging class of protocells that combine the dynamic properties of coacervate microdroplets with the structural advantages of membrane-bound systems. Leveraging features such as selective molecular uptake, enhanced reactivity, and dynamicity, they offer a promising platform for both fundamental research and technological applications in synthetic biology. In this concept, we introduce a classification of coacervate vesicles based on their formation mechanisms and energetic landscapes, highlighting how their formation routes give rise to protocells with distinct structural and dynamic properties.

Stereoselective Synthesis of Spiro-Decalin Oxindole Derivatives via Sequential Organocatalytic Michael-Domino Michael/Aldol Reaction.

A highly stereoselective procedure for the synthesis of spiro-polycyclic oxindoles bearing five contiguous stereogenic centers including two tetrasubstituted carbons has been developed. Under sequential organocatalysis performed by a pyrrolidine-based organocatalyst and DBU, a highly atom-economical Michael-domino Michael/aldol reaction sequence was optimized, yielding variously functionalized spiro-decalin oxindoles with excellent stereoselectivity (>99:1 dr, up to 92% ee).