Publications by authors named "Francesco Orsini"

L. is a widely used medicinal plant whose secondary metabolism and morphology are influenced by light. This study evaluated the effects of 2 and 4 h end-of-day (EOD) red/far-red (R:FR) and green (G) light on the growth, physiology, and phytochemical profile of hydroponically grown under a constant red/blue light background, compared with a red/blue control without EOD treatment.

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Introduction: Recent advancements in Artificial Intelligence have shown immense potential across various domains of healthcare, including forensic pathology. This systematic review aims to evaluate the latest innovations brought by Artificial Intelligence in forensic pathology and provide insights into future directions in this evolving field.

Methods: A systematic literature search was conducted using databases for papers published from 1990 to 2025.

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Vertical farming systems offer an efficient solution for sustainable food production in urban areas. However, managing nitrate (NO) levels remains a significant challenge for improving crop yield, quality, and safety. This study evaluated the effects of nitrate availability on growth performance, nutrient uptake, and water use efficiency in a vertical hydroponic system that intercropped lettuce () with alfalfa ().

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Magnetic nanoparticles offer the possibility of combining diagnostic and therapeutic purposes within a single nano-object. In this work, we explore two distinct sets of iron oxide-based nanospheres for their application as contrast agents in magnetic resonance imaging and as heating mediators in magnetic fluid hyperthermia. The nanoparticles were produced with the microwave polyol-assisted method.

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Unlabelled: Contrary to popular belief, a recent study did not show increased osteoclastic activity in acute complex regional pain syndrome. Conversely, osteoblastic activity seems to be enhanced. The real meaning of diagnostic tools needs to be reassessed.

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Article Synopsis
  • - This study focused on assessing the long-term effects of neridronate treatment on patients with Complex Regional Pain Syndrome type 1 (CRPS-1), a condition that causes severe pain and disability, particularly in the upper limbs.
  • - A retrospective analysis included 49 patients who received neridronate infusions, revealing that 93.9% of them experienced a complete resolution of symptoms after an average follow-up of about 4 years, with 77.6% showing no functional limitations.
  • - Key factors influencing residual disability post-treatment were found to be younger age and the delay between the onset of the disease and the start of treatment, suggesting that earlier intervention may lead to better recovery outcomes.
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  • Mosaic variegated aneuploidy (MVA) is a rare genetic disorder characterized by aneuploidies, mainly involving multiple chromosomes, leading to a variety of health issues like growth delay and congenital abnormalities.
  • A case study of a patient revealed a unique form of MVA with specific trisomies (mainly involving chromosomes 18 and 19) that caused intermittent mild neutropenia without severe symptoms over more than 20 years.
  • Genetic testing for known mutations related to MVA, as well as whole exome analysis, failed to identify any causative mutations, highlighting the complexity and uniqueness of this patient's condition.
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  • The study investigates serum levels of bone turnover markers and Wnt signaling in patients with complex regional pain syndrome type 1 (CRPS-1) before treatment.
  • It compares bone turnover marker values (sclerostin, DKK1, CTX-I, P1NP) of 34 CRPS-1 patients with age and sex-matched healthy controls, finding significant differences for P1NP, sclerostin, and DKK1.
  • Results suggest that early CRPS-1 is associated with increased bone formation markers and decreased levels of Wnt signaling inhibitors, indicating potential osteocyte dysfunction rather than increased osteoclast activity.
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Urban design is currently promoting the inclusion of plants in buildings. However, plants emit biogenic volatile organic compounds (BVOCs), which alone or in combination with other airborne molecules such as CO, may result in a general increase in tropospheric pollution. Many studies have documented the effects of biotic and abiotic factors on plant BVOC responses, but few have assessed the contribution of typical CO levels found in indoor work and meeting spaces.

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Introduction: This study aims to examine the potential effectiveness of intravenous neridronate (IVNer) on axial involvement in patients with spondyloarthritis (SpA) refractory to non-steroidal anti-inflammatory drugs (NSAIDs) but not eligible for biological disease-modifying antirheumatic drugs (bDMARDs).

Method: Patients with active SpA (BASDAI score ≥ 4) and active sacroiliitis (SI) on MRI (according to ASAS MRI definition), who were NSAID-insufficient responder/intolerant but not eligible for bDMARDs, were retrospectively recruited in a tertiary rheumatology centre between September 2015 and December 2021. IVNer (100 mg) was administered to the patients on days 1, 4, 7, and 10.

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Several rheumatologic diseases are primarily distinguished by their involvement of bone tissue, which not only serves as a mere target of the condition but often plays a pivotal role in its pathogenesis. This scenario is particularly prominent in chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). Given the immunological and systemic nature of these diseases, in this review, we report an overview of the pathogenic mechanisms underlying specific bone involvement, focusing on the complex interactions that occur between bone tissue's own cells and the molecular and cellular actors of the immune system, a recent and fascinating field of interest defined as osteoimmunology.

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Urban agriculture (UA) activities are increasing in popularity and importance due to greater food demands and reductions in agricultural land, also advocating for greater local food supply and security as well as the social and community cohesion perspective. This activity also has the potential to enhance the circularity of urban flows, repurposing nutrients from waste sources, increasing their self-sufficiency, reducing nutrient loss into the environment, and avoiding environmental cost of nutrient extraction and synthetization. The present work is aimed at defining recovery technologies outlined in the literature to obtain relevant nutrients such as N and P from waste sources in urban areas.

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Objective: To evaluate in patients with rheumatoid arthritis (RA) the impact of EMA recommendations on the real-life prescription of JAK inhibitors (JAKis) and the use of the Expanded Risk Score in RA (ERS-RA) to quantify the risk of major adverse cardiac events (MACE).

Methods: We conducted a retrospective analysis of real-life RA patients treated with JAKis. Patients were classified as ineligible for JAKis if they fulfilled EMA criteria (>65 years-old, history of malignancy, or increased risk of venous thromboembolic events [VTE] or MACE including smoking).

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We investigated the effect of different organic coatings on the H-NMR relaxation properties of ultra-small iron-oxide-based magnetic nanoparticles. The first set of nanoparticles, with a magnetic core diameter ds1 = 4.4 ± 0.

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Article Synopsis
  • The study investigates how proton therapy combined with hyperthermia using magnetic nanoparticles affects BxPC3 pancreatic cancer cells, with a focus on cellular responses and survival rates.
  • Findings reveal that this combination treatment significantly reduces cell survival compared to proton therapy alone, indicating a possible new effective therapy for pancreatic tumors.
  • Additionally, the presence of magnetic nanoparticles enhances radiosensitization and increases reactive oxygen species production, which contributes to DNA damage and cell death, paving the way for clinical application of this combined therapy.
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In this perspective article, we present a short selection of some of the most significant case studies on magnetic nanoparticles for potential applications in nanomedicine, mainly magnetic resonance. For almost 10 years, our research activity focused on the comprehension of the physical mechanisms on the basis of the nuclear relaxation of magnetic nanoparticles in the presence of magnetic fields; taking advantage of the insights gathered over this time span, we report on the dependence of the relaxation behaviour on the chemico-physical properties of magnetic nanoparticles and discuss them in full detail. In particular, a critical review is carried out on the correlations between their efficiency as contrast agents in magnetic resonance imaging and the magnetic core of magnetic nanoparticles (mainly iron oxides), their size and shape, and the coating and solvent used for making them biocompatible and well dispersible in physiological media.

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Urban green installations are extensively promoted to increase sustainable and accessible food production and simultaneously improve the environmental performance and liveability of city buildings. In addition to the multiple benefits of plant retrofitting, these installations may lead to a consistent increase in biogenic volatile organic compounds (BVOCs) in the urban environment, especially indoors. Accordingly, health concerns could limit the implementation of building-integrated agriculture.

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African agriculture is bound to face challenges for its future food systems development and economic transformation. Indoor vertical farms with artificial lighting represent an opportunity that has been gaining relevance worldwide, thanks to their potential to enable high productivity rates, food quality and safety, year-round production, and more sustainable use of water and mineral nutrients. The present study assesses the potential for vertical farming technology integration within the African continent, targeting the countries where a more sustainable approach could be achieved.

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The City Region Food Systems approach has been proposed to achieve food system resilience and nutrition security while promoting the urgent ecological transition within urban and peri-urban areas, especially after the COVID-19 pandemic. However, the great diversity of the initiatives composing City Region Food Systems in Europe poses barriers to the assessment of their integrated sustainability. Hence, the present work is developed within the EU-H2020 project Food System in European Cities (FoodE), to build a consistent sustainability scoring system that allows comparative evaluation of City Region Food System Initiatives.

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Light composition modulates plant growth and defenses, thus influencing plant-pathogen interactions. We investigated the effects of different light-emitting diode (LED) red (R) (665 nm) and blue (B) (470 nm) light combinations on performance by evaluating biometric parameters, chlorophyll a fluorescence, gas exchange and photosynthesis-related gene expression. Moreover, the influence of light on the infection by pv.

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Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease treatment, thanks to their ability to be liquid at room temperature and become viscous gels at body temperature. However, some problems, related to short in situ residence time, reduce their feasible clinical use.

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The development of Fricke gel (FG) dosimeters based on poly(vinyl alcohol) (PVA) as the gelling agent and glutaraldehyde (GTA) as the cross-linker has enabled significant improvements in the dose response and the stability over time of spatial radiation dose distributions. However, a standard procedure for preparing FG in terms of reagent concentrations is still missing in the literature. This study aims to investigate, by means of spectrophotometric analyses, how the sensitivity to the radiation dose and the range of linearity of the dose-response curve of PVA-GTA-FG dosimeters loaded with xylenol orange sodium salt (XO) are influenced by ferrous ammonium sulphate (FAS) and XO concentrations.

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