Publications by authors named "Francesca Vedovo"
Objectives: To compare the predictive performance of the World Health Organization (WHO) 1973, WHO 2004/2022, the three-tier (low grade [LG]/Grade 1 [G1]-G2, high grade [HG]/G2, and HG/G3), and four-tier (LG/G1, LG/G2, HG/G2, and HG/G3) hybrid grading systems in Ta non-muscle-invasive bladder cancer (NMIBC), by evaluating recurrence-free survival (RFS) and progression-free survival (PFS).
Patients And Methods: This retrospective multicentre study included 1233 patients with pTa NMIBC treated with transurethral resection of bladder tumour, eventually followed by intravesical instillations as determined by their physicians, between 2010 and 2023, across 18 Italian hospitals. Pathologists graded resected tissues using the WHO 1973, WHO 2004/2022 classifications, and hybrid three-tier (LG, HG/G2, HG/G3) and four-tier (LG/G1, LG/G2, HG/G2, HG/G3) systems.
Introduction: The Operated Male-to-Female Sexual Function Index (oMtFSFI) questionnaire is the first scoring system developed to assess sexual function after gender-affirming vulvo-vaginoplasty, and was initially developed and validated in Italian. The aim of this study was to provide linguistic validation of the questionnaire in French through several steps including use of the questionnaires across a series of patients who had undergone gender-affirming vulvo-vaginoplasty between 2020 and 2022 at two French academic centers.
Method: The French version of the oMtFSFI questionnaire was obtained through a double translation (Italian to French) and a back-translation (French to Italian), validated by a scientific committee, and cognitively assessed by a panel of expert patients.
Article Synopsis
- Transgender and gender-diverse individuals often face discrimination in medical settings, but gender-affirming treatments, like genital-affirming surgery, can enhance their quality of life; however, sexual function assessments after such surgeries have typically used tools meant for those assigned female at birth, leading to inaccuracies.
- The study involved translating and adapting the Male to Female Sexual Function Index (oMtFSFI) into Spanish for Chilean transgender women, testing its face validity through input from eight participants.
- Feedback indicated that while the questionnaire effectively evaluated sexual function, some terminology was confusing, and assumptions regarding partner presence and penetrative intercourse needed reconsideration, leading to an agreement on necessary adaptations based on patient perspectives.
Article Synopsis
- The study investigates the effectiveness of various inflammatory serum markers in predicting complications and readmission following radical cystectomy for bladder cancer.
- The research involved analyzing data from 271 patients who underwent the procedure between 2012 and 2022, utilizing logistic regression for statistical analysis.
- Key findings included that factors like current smoking, high plasma fibrinogen levels, and preoperative anemia were linked to major complications, while elevated C-reactive protein and fibrinogen levels were associated with higher likelihoods of unplanned 30-day readmissions.
Article Synopsis
- The incidence of renal cancer is rising, especially among older patients, making surgical management more complex due to patient frailty.
- A study evaluated the G8 score as a screening tool to assess postoperative complications in elderly patients (≥70 years) undergoing kidney cancer surgery, involving 162 participants classified into frail and non-frail groups.
- Results showed a significant correlation between frailty and the likelihood of complications, with 52 frail patients experiencing postoperative issues compared to only 4 non-frail patients, indicating the G8 score's effectiveness in predicting surgical risks in this age group.
Background: Several trials have reported on the impact of social restrictions due to SARS-CoV-2 (COVID-19) pandemic on sexual function and psycho-physical well-being. However, data showing modifications of these outcomes over time and at the end of lock-down are scant.
Aim: We investigated the longitudinal changes in sexual function during social restrictions for COVID-19 pandemic in Italy.
Background: Few studies have investigated how physical, mental and sexual function are associated with each other in operated transgender women (oTW).
Aim: To provide information on the physical, mental and sexual health of oTW in comparison with a group of cisgender women (cisW).
Methods: An age-matched control study was carried out, recruiting 125 oTW in 7 national referral centers and 80 volunteer women.
Introduction: Percutaneous treatment of persistent urinary fistula after partial nephrectomy using N-butyl-2-cyanoacrylate and gelatin sponge (Spongostan®) is an effective and relatively non-invasive procedure that should be considered when a conservative approach fails. Three successful cases of percutaneous embolization by using N-butyl-2-cyanoacrylate have been reported in the literature. To our knowledge, the use of Spongostan for the treatment of urinary fistula after partial nephrectomy has not been previously described.
View Article and Find Full Text PDFPurpose: No questionnaire is currently available to evaluate sexual function after male-to-female gender affirming surgery. Such a limit leads to a suboptimal evaluation in postoperative sexual function in these patients. We developed and validated a new questionnaire, the oMtFSFI (operated Male-to-Female Sexual Function Index), for assessing sexual function in male-to-female patients after surgery.
View Article and Find Full Text PDFArticle Synopsis
- The article presents a new surgical technique called "M-shape neoclitorolabioplasty" for improving the design of clitoral and labial structures in male-to-female gender affirming surgery.
- The process involves isolating the glans and creating an M-shaped flap that transforms into a neoclitoris and labia minora, all while preserving erogenous sensitivity.
- Results from 94 patients show a high success rate, with 86.1% able to engage in vaginal intercourse and 82.9% experiencing erogenous sensitivity post-surgery.
Systematic review of studies reporting perioperative and functional outcomes following male-to-female gender assignment surgery (MtoF GAS): a call for standardization in data reporting.
Minerva Urol Nefrol
October 2019
Introduction: The aim of this study is to accomplish a systematic review on the surgical techniques available for male-to-female gender assignment surgery (MtoF GAS) published in the last 15 years, from January 2002 to May 2017, assessing advantages and disadvantages.
Evidence Acquisition: A specific search on MEDLINE, Scopus and Web of Science databases included vaginoplasty for gender exchange. Preoperative (age, gender, body mass index, prior surgery), intraoperative (mean operating time, intraoperative complications, transfusion rate, conversion rate), postoperative (hospital stays, readmission rate, early and late complication rate), postoperative sexual activity, subjective satisfaction, vaginal depth, and long-term outcomes (vaginal stenosis, prolapse, dyspareunia and labial abscess) data of vaginoplasty for sexual exchange were collected.
Objective: To present a novel surgical concept by using the trans-Douglas approach to perform a robotic-assisted simple prostatectomy (RASP) for high-volume benign prostate hyperplasia. This transposition from oncological surgery enables performance of a better bladder neck sparing adenomectomy with good functional results.
Materials And Methods: The index patient is a 67-year-old man with a history of severe urinary flow outlet obstruction.
Objective: To investigate the role of MRI in the evaluation of both the new female anatomy and complications in male-to-female sex reassignment surgery (MtF-SRS).
Methods: 71 consecutive patients with MtF-SRS had 74 MRI [age range, 21-63 years; mean (±standard deviation) age, 36 ± 10 years; median age, 37 years]. In 47 patients, MRI was performed to rule out early post-operative complications after gender conversion (n = 40), vaginoplasty (n = 6) or remodelling of the labia majora (n = 1).
Penile fracture: retrospective analysis of our case history with long-term assessment of the erectile and sexological outcome.
Arch Ital Urol Androl
December 2014
Objectives: To review the cases of patients with suspected penile fracture and asses erectile and sexological outcomes.
Materials And Methods: from 1987 to 2013 presented to the Urology Clinic of Trieste and at the AIED of Pordenone a total of 41 cases that were divided into two groups according to the timing of treatment: 18 patients with anamnestic diagnosis of penile fracture treated nonimmediately and 23 patients treated immediately after the trauma. For all patients we evaluated the type of treatment adopted, the occurrence of complications and reoperations and the follow-up.
We present the case and radiologic images of a 64-year-old man who presented with gross hematuria and fever 2 months after undergoing retroperitoneal partial nephrectomy for a 4.7 × 4.6 cm papillary renal cell carcinoma.
View Article and Find Full Text PDFWe report a case of primary renal lymphoma of mucosa-associated lymphoid tissue in an 82-year-old woman. She presented with a history of renal mass previously treated with kidney percutaneous cryoablation at another centre.
View Article and Find Full Text PDFIntroduction: Lymphoid neoplasms of the urinary tract and male genital organs are relatively rare, comprising less than 5% of all primary extranodal lymphomas; only a handful of small case series and isolated case reports have been published to describe their predominant sites and subtypes.
Materials And Methods: We searched our institution's electronic archive of pathology reports from
2001 to 2012. We considered lymphoid neoplasms involving the kidney, bladder, testes and prostate.