New Alternatives in the Valorisation of By-Products for the Textile Industry.

The textile industry requires products with a wide range of characteristics for use in diverse applications such as the production of shoes, bags, jackets, thermal clothing and articles for the automotive industry, among others. These products have traditionally been made from leather, which is obtained from animal hides. However, leather production has come under enormous pressure due to sustainability concerns in various areas and the growing number of people who actively choose to avoid all animal products.

Self-assembled inorganic nanomaterials for biomedical applications.

Controlled self-assembly of inorganic nanoparticles has the potential to generate complex nanostructures with distinctive properties. The advancement of more precise techniques empowers researchers in constructing and assembling diverse building blocks, marking a pivotal evolution in nanotechnology and biomedicine. This progress enables the creation of customizable biomaterials with unique characteristics and functions.

Effect of Lignosulphonates on the Moisture Resistance of Phenol-Formaldehyde Resins for Exterior Plywood.

Phenol-formaldehyde (PF) resins remain the preferred adhesive for exterior plywood, as they confer these boards their extreme weather resistance. However, their high price and toxicity has made phenol alternatives, such as technical lignins, increasingly more attractive. While many works report the use of kraft lignin, the most commercially available form are lignosulphonates (LS).

New MoS/Tegafur-Containing Pharmaceutical Formulations for Selective LED-Based Skin Cancer Photo-Chemotherapy.

Non-melanoma skin cancer (NMSC) is one of the most common types of cancer worldwide. Despite the low mortality rate, rising incidence and recurrence rates are a burden on healthcare systems. Standard treatments such as chemotherapy, radiotherapy, and surgery are either invasive or toxic to healthy tissues; therefore, new, alternative, selective treatments are needed.

New graphene-containing pharmaceutical formulations for infrared lamps-based phototherapy of skin cancer: In vitro validation and ex-vivo human skin permeation.

Basal cell carcinoma (BCC) is the most common form of human cancer, and treatment usually involves surgery, with alternative strategies being needed. We propose the use of carbopol hydrogels (HG) for topical administration of nanographene oxide (GOn) and partially-reduced nanographene oxide (p-rGOn) for photothermal therapy (PTT) of BCC. GOn and p-rGOn incorporated into the HG present lateral sizes ∼200 nm, being stable for 8 months.

Pharmaceutical Formulations Containing Graphene and 5-Fluorouracil for Light-Emitting Diode-Based Photochemotherapy of Skin Cancer.

Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide, among which 80% is basal cell carcinoma (BCC). Current therapies' low efficacy, side effects, and high recurrence highlight the need for alternative treatments. In this work, a partially reduced nanographene oxide (p-rGOn) developed in our laboratory was used.

Long-term in vivo degradation and biocompatibility of degradable pHEMA hydrogels containing graphene oxide.

Developing biocompatible, non-fouling and biodegradable hydrogels for blood-contacting devices remains a demanding challenge. Such materials should promote natural healing, prevent clotting, and undergo controlled degradation. This study evaluates the biocompatibility and biodegradation of degradable poly(2-hydroxyethyl methacrylate) (d-pHEMA) hydrogels with or without reinforcement with oxidized few-layer graphene (d-pHEMA/M5ox) in a long term implantation in rats, assessing non-desired side-effects (irritation, chronic toxicity, immune response).

UV-C driven reduction of nanographene oxide opens path for new applications in phototherapy.

The main challenges associated to the application of graphene-based materials (GBM) in phototherapy are obtaining particles with lateral nanoscale dimensions and water stability that present high near-infrared (NIR) absorption. Nanosized graphene oxide (GOn) is stable in aqueous dispersion, due to the oxygen functionalities on its surface, but possesses low photothermal efficiency in NIR region. GOn total reduction originates reduced nanographene oxide (rGOn) that presents high NIR absorption, but poor water stability.

2D Nanomaterials and Their Drug Conjugates for Phototherapy and Magnetic Hyperthermia Therapy of Cancer and Infections.

Photothermal therapy (PTT) and magnetic hyperthermia therapy (MHT) using 2D nanomaterials (2DnMat) have recently emerged as promising alternative treatments for cancer and bacterial infections, both important global health challenges. The present review intends to provide not only a comprehensive overview, but also an integrative approach of the state-of-the-art knowledge on 2DnMat for PTT and MHT of cancer and infections. High surface area, high extinction coefficient in near-infra-red (NIR) region, responsiveness to external stimuli like magnetic fields, and the endless possibilities of surface functionalization, make 2DnMat ideal platforms for PTT and MHT.

3D Printed Magneto-Active Microfiber Scaffolds for Remote Stimulation and Guided Organization of 3D In Vitro Skeletal Muscle Models.

This work reports the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting (MEW) of a magnetized polycaprolactone-based composite. In situ iron oxide nanoparticle deposition on oxidized graphene yields homogeneously dispersed magnetic particles with sizes above 0.5 µm and low aspect ratio, preventing cellular internalization and toxicity.

Nanomaterials for Skin Cancer Photoimmunotherapy.

Skin cancer is one of the most common types of cancer, and its incidence continues to increase. It is divided into two main categories, melanoma and non-melanoma. Treatments include surgery, radiation therapy, and chemotherapy.

Poly(2-hydroxyethyl methacrylate) hydrogels containing graphene-based materials for blood-contacting applications: From soft inert to strong degradable material.

Degradable biomaterials for blood-contacting devices (BCDs) are associated with weak mechanical properties, high molecular weight of the degradation products and poor hemocompatibility. Herein, the inert and biocompatible FDA approved poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel was turned into a degradable material by incorporation of different amounts of a hydrolytically labile crosslinking agent, pentaerythritol tetrakis(3-mercaptopropionate). In situ addition of 1wt.

Novel Approach for a Controlled Delivery of Essential Oils during Long-Term Maize Storage: Clove Bud and Pennyroyal Oils Efficacy to Control , Reducing Grain Damage and Post-Harvest Losses.

Maize grains represent a significant contribution for assuring food safety all over the globe. (Motschulsky) (Coleoptera: Curculionidae), also known as the maize weevil, is one of the most destructive pests in stored maize, causing qualitative and quantitative losses. To control populations in maize storage sites, synthetical chemical insecticides are applied.

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy.

Conventional cancer therapies, such as radiotherapy and chemotherapy, can have long-term side effects. Phototherapy has significant potential as a non-invasive alternative treatment with excellent selectivity. Nevertheless, its applicability is restricted by the availability of effective photosensitizers and photothermal agents, and its low efficacy when it comes to avoiding metastasis and tumor recurrence.

The Potential of Visible Spectroscopy as a Tool for the In-Line Monitoring of Lignin Methylolation.

Out of the 50 to 70 million tons of lignin that are produced annually, only 1 to 2% are used for value-added products. Currently, 90% of the total market of this compound corresponds to lignosulphonates (LS). The most successful industrial attempts to use lignin for wood adhesives rely on using it as a partial substitute in phenol-formaldehyde or urea-formaldehyde resins.

Comparative Study of Friction and Wear Performance of PEK, PEEK and PEKK Binders in Tribological Coatings.

Tribological coatings are widely used in industry, particularly when the conventional oil lubrication of sliding surfaces has to be replaced by maintenance-free contacts. This work studies the tribological performance of waterborne tribological coatings based on three binders of the polyaryletherketone (PAEK) family: polyetherketone (PEK), PEEK, and polyetherketoneketone (PEKK). Even though PEEK is a well-known commercial solution for this type of tribological coatings, PEK and PEKK have never been studied in such a context.

Flexible Composite Films Made of EMAANa Ionomer: Evaluation of the Influence of Piezoelectric Particles on the Thermal and Mechanical Properties.

Studies that aim to produce flexible films of composite materials based on ionomers-PZT, and volume fractions lower than 10% PZT, in order to monitor damage in aeronautical structures are seldom investigated. The growing emphasis on the use of polymers capable of self-healing after damage or activation by heating has motivated the application of self-healing ionomers as polymeric matrices in composites with piezoelectric particles aiming to monitor damage. Flexible composite films were developed based on the self-healing polymer matrix Surlyn 8940 ionomer (DuPont-Wilmington, DE, USA) and PZT particles (connectivity 2-3) in volume fractions of 1, 3, 5 and 7%, with thickness around 50-100 µm.

New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications.

The constant evolution and advancement of the biomedical field requires robust and innovative research. Two-dimensional nanomaterials are an emerging class of materials that have risen the attention of the scientific community. Their unique properties, such as high surface-to-volume ratio, easy functionalization, photothermal conversion, among others, make them highly versatile for a plethora of applications ranging from energy storage, optoelectronics, to biomedical applications.

Grape Canes ( L.) Applications on Packaging and Particleboard Industry: New Bioadhesive Based on Grape Extracts and Citric Acid.

The main by-product generated in the wine industry are the grape canes, derived from the pruning process. In order to increase the valorisation possibilities of this highly polyphenolic lignocellulosic material, this work focuses on its applicability in the materials industry. As a first step, we demonstrate the viability of using grape cane particles as raw material for particleboard production, combined with a melamine formaldehyde urea (MFU) binder.

Fabrication of Polymer/Graphene Biocomposites for Tissue Engineering.

Graphene-based materials (GBM) are considered one of the 21st century's most promising materials, as they are incredibly light, strong, thin and have remarkable electrical and thermal properties. As a result, over the past decade, their combination with a diverse range of synthetic polymers has been explored in tissue engineering (TE) and regenerative medicine (RM). In addition, a wide range of methods for fabricating polymer/GBM scaffolds have been reported.

Using Graphene-Based Materials for Stiff and Strong Poly(ethylene glycol) Hydrogels.

Blood-contacting devices are increasingly important for the management of cardiovascular diseases. Poly(ethylene glycol) (PEG) hydrogels represent one of the most explored hydrogels to date. However, they are mechanically weak, which prevents their use in load-bearing biomedical applications (e.

Lignosulphonates as an Alternative to Non-Renewable Binders in Wood-Based Materials.

Lignin is a widely abundant renewable source of phenolic compounds. Despite the growing interest on using it as a substitute for its petroleum-based counterparts, only 1 to 2% of the global lignin production is used for obtaining value-added products. Lignosulphonates (LS), derived from the sulphite pulping process, account for 90% of the total market of commercial lignin.

Graphene Oxide Topical Administration: Skin Permeability Studies.

Nanostructured carriers have been widely used in pharmaceutical formulations for dermatological treatment. They offer targeted drug delivery, sustained release, improved biostability, and low toxicity, usually presenting advantages over conventional formulations. Due to its large surface area, small size and photothermal properties, graphene oxide (GO) has the potential to be used for such applications.

Graphene-based materials: the key for the successful application of pHEMA as a blood-contacting device.

Thrombosis and infection are the leading causes of blood-contacting device (BCD) failure, mainly due to the poor performance of existing biomaterials. Poly(2-hydroxyethyl methacrylate) (pHEMA) has excellent hemocompatibility but the weak mechanical properties impair its use as a bulk material for BCD. As such, pHEMA has been explored as a coating, despite the instability and difficulty of attachment to the underlying polymer compromise its success.