Targeting SPATS2 in lung adenocarcinoma: implications for prognosis and immune-based therapy.

Background: Lung adenocarcinoma (LUAD) is a major contributor to cancer mortality and exhibits high intratumoral heterogeneity. The functional role of SPATS2 in LUAD remains poorly defined.

Methods: We integrated transcriptomic data from TCGA, GTEx, and GEO databases to evaluate SPATS2 expression patterns and their associations with clinical features and prognosis in LUAD.

Epidemiological trends and risk factors of chronic obstructive pulmonary disease in young individuals based on the 2021 global burden of disease data (1990-2021).

Objective: Recent studies have shown that chronic obstructive pulmonary disease (COPD) in young individuals cannot be ignored. This study aims to investigate the burden of COPD and its associated risk factors in individuals aged 15 to 49 years, with a particular focus on health inequities across different levels of socioeconomic development.

Methods: By analyzing data from the Global Burden of Disease (GBD) 2021, we utilized statistical methods such as Joinpoint regression, frontier analysis, and health inequality analysis to evaluate the changes in the age-standardized disability-adjusted life year (DALY) rates (ASDR) and incidence rates (ASIR) of COPD among the global population aged 15-49 years from 1990 to 2021.

SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-β1-induced airway smooth muscle cells by regulating TLR2/NF-κB/NFATc1/ABCA1 regulatory network.

Asthma is a respiratory disease with complex pathogenesis. Sterol-responsive element-binding proteins 2 (SREBP2) was found to bind to promoter sequences of ABCA1 to suppress ABCA1 promoter activity. This study aimed to explore the expression level of SREBP2 and ATP-binding cassette transporter A1 (ABCA1), and their effects on the development of airway smooth muscle cells (ASMCs) in asthma.

TGF-β1/SMOC2/AKT and ERK axis regulates proliferation, migration, and fibroblast to myofibroblast transformation in lung fibroblast, contributing with the asthma progression.

Background: Asthma is a common chronic respiratory disease that influences 300 million people all over the world. However, the pathogenesis of asthma has not been fully elucidated. It has been reported that transforming growth factor-β (TGF-β) can activate myofibroblasts.