Publications by authors named "Eveline Vriens"
Article Synopsis
- Type IV pili (T4P) are structures on the surface of gram-negative bacteria that enable various functions such as attaching to surfaces, forming biofilms, and moving around.
- * A protein called PlzR was found to inhibit the assembly of T4P in Pseudomonas aeruginosa, affecting how the bacteria can be infected by certain bacteriophages.
- * PlzR binds to a T4P chaperone called PilZ, disrupting the proper assembly of T4P by influencing an ATPase named PilB, and its expression is regulated by levels of cyclic di-GMP.
Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents.
Angew Chem Int Ed Engl
August 2023
Article Synopsis
- Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are large enzymes that create various bioactive compounds, including anticancer agents like oximidine.
- Researchers identified the gene cluster for oximidine in the bacterium Pseudomonas baetica and discovered four new variants, highlighting a simpler intermediate with strong anticancer properties.
- The study also detailed the oximidine biosynthesis process, revealing a unique mechanism for forming O-methyloxime involving a specific monooxygenase and methyltransferase, expanding knowledge on trans-AT PKSs and their potential for creating new drug variants.