The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia.

Background: During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called "inflammaging". Frailty represents a condition of increased vulnerability to stresses and reduced homeostatic reserve reflecting not only health status but also biological age. In older subjects without dementia, we showed that markers of inflammaging were differently associated with chronological age than with frailty.

Frailty in Persons with Down Syndrome: Results from the REVIVIS Study.

Objectives: To determine frailty prevalence and identify possible nonclinical factors associated with this condition in community-dwelling individuals with Down syndrome (DS).

Design: Cross-sectional analysis of the registry study REVIVIS, a single-center, prospective study on the geriatric management of persons with DS.

Setting And Participants: Individuals with DS (n = 139) referred to a geriatric clinic.