Microbiome and immunotherapy in bladder cancer: The missing link.

Background: Bladder cancer remains a significant global health concern, with immunotherapies such as Bacillus Calmette-Guérin (BCG) and immune checkpoint inhibitors (ICIs) playing pivotal roles in treatment. Emerging evidence suggests that the microbiome, encompassing both gut and urinary tract microorganisms, may influence the efficacy and outcomes of these immunotherapies.

Objective: This review aims to explore the intricate relationship between the microbiome and immunotherapy in bladder cancer, highlighting current research findings, potential mechanisms, and future therapeutic implications.

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The Conférence nationale de santé (CNS) (French National Health Conference) is a consultative health democracy body that reports to the Minister of Health. After deciding to examine oral health as part of its work program, the Director General of Health asked the CNS to submit a report by the end of 2024. These recommendations are a summary of more than forty working meetings and thirty-two hearings held over a period of nine months.

Youth matters: a systematic review of the molecular and clinical landscape of bladder cancer in young adults.

Background: Bladder cancer is uncommon in individuals under the age of 45, and its clinical and molecular characteristics in this population differ significantly from those observed in older patients. This systematic review aims to evaluate recurrence, progression, survival outcomes, and molecular profiles of bladder cancer in young adults.

Methods: A systematic search was conducted in MEDLINE, Embase, Scopus, and CENTRAL databases for studies published between 1998 and 2024.

Ethical and pedagogical reflections around serious games in patients education (PE): : ?

Background: The serious game in healthcare, part of the e-health segment, aims to develop, in a fun and educational way, the skills needed for better day-to-day management of chronic diseases in patients and their families, using video games as part of patient education (PE) programmes. Several ethical questions have been raised concerning the introduction of gamification into health education activities, particularly in PE.

Objectives: This descriptive research aimed to identify the obstacles and levers to using edutainment practices with adult patients.

Latent Classes Analysis Approach of Intimate Partner Violence Victimization and Perpetration in Emerging Adulthood.

This study sought to identify classes of intimate partner violence (IPV) among emerging adults reporting both victimization and perpetration, as well as the co-occurrence of multiple forms of violence (i.e., psychological, physical, and sexual) and the association of psychosocial vulnerability factors (i.

Internal consistency of the Mental Health Professional Culture Inventory: A pilot study in Romanian population.

The objective of this study (registered under number 2020 006) was to assess the internal consistency of the revised Mental Health Professional Culture Inventory (MHPCI) scale, which comprises 15 items, among mental health service workers in Romania. To examine the psychometric properties of the MHPCI questionnaire within the Romanian population, we employed two main methods: The partial credit model (PCM) and Exploratory factor analysis (EFA). A total of 94 individuals were interviewed, and among them, 71 provided complete responses to the questionnaire.

[Supporting the applicability and transferability of the “Sortir Ensemble & Se Respecter” program in France].

Introduction: The prevention of intimate partner violence (IPV) among young people is a major challenge for public policies. Nevertheless, there are a few prevention programs that have proven effective in France. “Sortir Ensemble & Se Respecter” (SE&SR) is a Swiss adaptation of “Safe Dates,” an American intervention program that has reduced violent behavior by young perpetrators and victims of IPV alike.

[Emergence of the “e-patient” and “e-caregiver” around a serious game in ETP].

Introduction: The advent of e-health has an impact on many areas of health care practice, including TPE. The impact of the introduction of information and communication technologies (ICTs) in health care, such as serious games, remains largely unexplored in the field of e-TPE.

Purpose Of The Research: To ask patients and health care professionals about the use of a serious game, in order to clarify the impact of these technologies on health care practices and on the relationship between caregiver and patient, as well as their advantages and limitations.

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The focus of patient education has shifted from a biomedical to a biopsychosocial model, and it is now at the heart of the strategies set out in the Ottawa Charter for Health Promotion: the development of individual skills, the creation of supportive environments through the care experience, the consolidation of the community approach through patient partnerships, and the reorientation of health services toward preventive clinical practices and population-based responsibility. The implementation of health-promoting patient education calls for the development of a health education continuum and the involvement of all health promotion actors.

Parental Attachment, Self-Esteem, Social Problem-Solving, Intimate Partner Violence Victimization in Emerging Adulthood.

Emerging adults can experience conflicts with their dating partner, leading to intimate partner violence (IPV). In order to understand the vulnerability factors involved in IPV victimization, the current study explored a serial multiple mediation model to determine the links between parental attachment (to the father and mother), self-esteem, and social problem solving (SPS) on the three forms of IPV (psychological, physical and sexual). Based on an online survey, 756 emerging adults (84.

Dysfunctional Attitudes, Sociotropy-Autonomy, and Intimate Partner Violence Victimization in Emerging Adulthood.

Understanding the dynamics and vulnerability factors involved in intimate partner violence (IPV) victimization among emerging adults is important in order to better prevent it from happening. The current study aimed to investigate the relationships among dysfunctional attitudes, sociotropy-autonomy, and types of IPV victimization (i.e.

Self-Esteem, Social Problem Solving and Intimate Partner Violence Victimization in Emerging Adulthood.

Although there are many studies examining the psychosocial vulnerability factors of intimate partner violence (IPV) victimization in emerging adulthood, little is known about the life skills that may be involved, such as social problem solving (SPS) and self-esteem. The aim of the current study is to explore the relationships between SPS, self-esteem, and types (i.e.

Understanding Inequalities in the Uptake of Supportive Care to Improve Practices in the Cancer Care Continuum.

(1) Background: While inequalities in the prevalence of cancer, access to care, and survival have been well documented, less research has focused on inequalities in the uptake of supportive oncology care. Given its contribution to improving the quality of life of people affected by cancer, access to such care is a major public health issue. The present study focuses on the access and uptake of those supportive oncology care services.

A Home-Mailed Versus General Practitioner-Delivered Vaginal Self-Sampling Kit for Cervical Cancer Screening: A Cluster Randomized Controlled Trial with a Cost-Effectiveness Analysis.

We assessed whether general practitioner (GP) delivery of a vaginal self-sampling kit was non-inferior to home-mailed delivery on cervical cancer screening (CCS) participation. Two hundred and ten French GPs from Indre-et-Loire French department were randomized into two groups, and their unscreened women patients aged 30-65 were included in February-March 2015. In the GP delivery group ( = 105 GPs; 1,806 women), women were sent a reminder letter inviting them to collect a vaginal self-sampling kit at their regular GP's practice.

How are patients' preferences for anti-TNF influenced by quality of life? A discrete choice experiment in Crohn's disease patients.

Background And Objective: Anti-TNFs have been shown to significantly improve the health-related quality of life (HRQoL) in Crohn's disease (CD) patients. The purpose of this study was to investigate to what extend the patients' preferences for these intravenous (IV) and subcutaneous (SC) treatments differ based on respondents' quality of life. An online discrete choice experiment (DCE) was conducted to understand patient trade-offs in treatment choice.

COVID-19 and Physical Distancing Measures: Experience of Psychiatric Professionals in Europe.

A The COVID-19 pandemic has had a considerable impact on the organization of psychiatric care. The present study examines how care professionals experienced this period and faced these new constraints weighing on their professional practices. Based on a qualitative research methodology, 13 group interviews with healthcare professionals working in psychiatric wards were conducted in five countries in western Europe.

Predictors of each quality of life dimension in Crohn's disease patients initiating an anti-TNF treatment: differentiated effects of patient-, disease-, and treatment-related characteristics.

Background And Aims: In Crohn's disease (CD), a composite therapeutic target was recently recommended, including both objective measurement (endoscopic remission) and Patient-Reported Outcomes (resolution of abdominal pain and normalization of bowel function). All dimensions of health-related quality of life (HRQoL) are impacted: not only bowel symptoms but also systemic symptoms, emotional wellbeing and social function. Thus, understanding the predictors of each HRQoL dimension would improve patient management.

What is the impact of blood pressure on neurological symptoms and the risk of ESKD in primary and secondary thrombotic microangiopathies based on clinical presentation: a retrospective study.

Background: The impact of blood pressure on neurological symptoms and risk of end-stage kidney disease (ESKD) is unknown in primary and secondary thrombotic microangiopathies (TMAs).

Methods: We measured baseline systolic (SBP) and diastolic (DBP) BP in consecutive 563 patients with adjudicated primary and secondary TMAs, and assessed its association with the risk of ESKD.

Results: Normal BP, grade 1, 2 and 3 hypertension were present in 243 (43.

International professional practices in mental health, organization of psychiatric care, and COVID-19: A survey protocol.

Objective: Our project aims to provide: an overview of the impact of the COVID-19 pandemic on the field of mental health professionals in 23 countries;a model of recommendations for good practice and proposals for methods and digital tools to improve the well-being at work of mental health professionals and the quality of services offered during crisis and post-crisis periods;an in-depth ethics review of the assessment of the use of numerical tools for psychiatry professionals and patient support, including teleconsulting.

Methods: This is a large international survey conducted among 2,000 mental health professionals in 23 countries over a 12-month period. This survey will be based on 30 individual interviews and 20 focus group sessions, and a digital questionnaire will be sent online to 2,000 professionals based on the criteria of gender, age, professional experience, psychiatric specialty, context of work in psychiatry, and geographical location.

Infection in Patients with Suspected Thrombotic Microangiopathy Based on Clinical Presentation.

Background And Objectives: In contrast to shigatoxin-associated (STEC) causing hemolytic uremic syndrome, STEC-unrelated infections associated with thrombotic microangiopathy are less characterized.

Design, Setting, Participants, & Measurements: Our retrospective study in a four-hospital institution of 530 consecutive patients with adjudicated thrombotic microangiopathies during the 2009-2016 period studied STEC-unrelated infections' epidemiology and major outcomes (death, acute dialysis, and major cardiovascular events).

Results: STEC-unrelated infection was present in 145 of 530 (27%) patients, thrombotic microangiopathies without infection were present in 350 of 530 (66%) patients, and STEC causing hemolytic and uremic syndrome was present in 35 of 530 (7%) patients.