Publications by authors named "Eline F M Oerlemans"
Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli.
Cell Rep Med
February 2022
Article Synopsis
- Tailored skin microbiome modulation with probiotics, specifically lactobacilli, shows promise in treating acne while being traditionally undervalued in skin health.
- Specific strains of nomadic lactobacilli are selected and microencapsulated for topical use, demonstrating effectiveness in reducing inflammation and lesions in patients with mild-to-moderate acne during a pilot study.
- After 8 weeks of daily application, results indicate a lasting improvement in skin condition, including a decrease in harmful bacteria and a temporary shift in the skin microbiome, suggesting potential immunomodulatory benefits.
While bacterial vaginosis (BV) is a well-known type of vaginal dysbiosis, aerobic vaginitis (AV) is an inflammatory condition that remains understudied and under-recognised. It predisposes women to serious complications including urogenital infections and pregnancy problems. Here, we investigated the bacterial community in AV to explore its possible role in AV pathogenesis.
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- * The study tested three specific strains of Lactobacillus in a vaginal gel on 20 women with acute VVC over four weeks, observing their microbiome through various scientific methods.
- * Results showed that 45% of women treated with the probiotic gel did not need additional medication, and their fungal levels were comparable to those treated with fluconazole, suggesting probiotic lactobacilli may be effective without harming beneficial vaginal bacteria as azoles do.
Lactobacilli have been evaluated as probiotics against Candida infections in several clinical trials, but with variable results. Predicting and understanding the clinical efficacy of Lactobacillus strains is hampered by an overall lack of insights into their modes of action. In this study, we aimed to unravel molecular mechanisms underlying the inhibitory effects of lactobacilli on hyphal morphogenesis, which is a crucial step in C.
View Article and Find Full Text PDFCarrot Juice Fermentations as Man-Made Microbial Ecosystems Dominated by Lactic Acid Bacteria.
Appl Environ Microbiol
June 2018
Article Synopsis
- - Spontaneous vegetable fermentations, specifically carrot juice, are becoming popular due to their flavor and potential health benefits, but their microbiological processes are not well understood, raising food safety concerns.
- - A study analyzed samples from 38 carrot juice fermentations collected via citizen science, finding that lactic acid bacteria (LAB) dominated after just a few days and produced metabolites like lactic acid and cadaverine.
- - Genetic analyses revealed a high diversity of LAB, revealing their roles in fermentation, but only certain strains maintained the fermentation dynamics, highlighting the carrot juice fermentation as a valuable system for studying LAB and their ecological interactions.
To improve our understanding of upper respiratory tract (URT) diseases and the underlying microbial pathogenesis, a better characterization of the healthy URT microbiome is crucial. In this first large-scale study, we obtained more insight in the URT microbiome of healthy adults. Hereto, we collected paired nasal and nasopharyngeal swabs from 100 healthy participants in a citizen-science project.
View Article and Find Full Text PDFA number of clinical studies have shown protective effects of lactobacilli against Candida species in the gastrointestinal tract, the urogenital tract and the oral cavity, while others did not show clear effects. Evidence on the mode of action of lactobacilli against Candida is also still lacking. In this study, the anti-Candida activity of the model probiotic strain Lactobacillus rhamnosus GG was explored in different assays to determine molecular interactions.
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