Strategies for Tailoring Patient-Centered Technologies Across the Cancer Continuum: Protocol for a Scoping Review.

Background: In the United States, cancer is more prevalent in racial and ethnic minority groups and in rural-dwelling and low-income people. Compared with White people of non-Hispanic descent, Black and African American people have higher cancer mortality and Hispanic people are more likely to be diagnosed with infection-related cancers. In addition, people who live in persistent poverty areas are more vulnerable to cancer mortality.

Impact of age and treatment-related adverse events on financial toxicity among patients with breast cancer: a systematic review.

Purpose: Increasing incidence of breast cancer among young adults (YA), defined by the National Comprehensive Cancer Network (NCCN) as age < 40 years, has amplified concerns over financial toxicity (FT) in this demographic. This systematic review sought to clarify the association between YA status and FT.

Methods: We queried bibliographic databases for full-text English language publications between 2010 and 2024 reporting FT using validated patient-reported outcome metrics among patients with stage I-III breast cancer.

Impact of a Weight Loss Intervention on 1-Year Weight Change in Women With Stage II/III Breast Cancer: Secondary Analysis of the Breast Cancer Weight Loss (BWEL) Trial.

Importance: Obesity is associated with a higher risk of recurrence, mortality, comorbidities, treatment-related adverse effects, and poor quality of life in patients with breast cancer. Scalable interventions are needed to promote weight loss in this population.

Objective: To evaluate the impact of a remotely delivered weight loss intervention (WLI) on weight change at 1 year in patients with breast cancer and obesity and to explore factors associated with weight change.

Serum profiling of the antibody response to HPV in women with or without abnormal cervical cytology undergoing cervical cancer screening.

Introduction: Understanding the humoral immune response to HPV is important for understanding the natural history of infection and developing biomarkers for early detection of cervical cancer. This has been technically limited by HPV type diversity and challenges of high-throughput protein expression and display. This study aimed to profile the humoral immune response to the proteomes of 12 HPV types in women with or without abnormal cervical cytology undergoing cervical cancer screening.

A Society-to-Cells approach to evaluating multilevel and interrelated drivers of breast cancer disparities in Black women.

Despite advances in detection and treatment, Black women in the US continue to experience more aggressive breast cancer subtypes and higher mortality. Framed through a Society-to-Cells lens, this review presents a comprehensive framework for understanding how multilevel drivers-from structural forces to cellular responses-interact to perpetuate disparities. Addressing these inequities requires systemic reforms targeting root causes, including policies to redress historical neighborhood disinvestment and eliminate bias within healthcare systems.

Impact of COVID Pandemic on Financial Burdens in Metro and Non-Metro Regions: Findings from a Cross-Sectional Survey.

Purpose: The impact of the COVID-19 pandemic on employment and various financial burden domains has not been well researched, particularly in vulnerable populations. This study examined the impact of the pandemic among those living in an Ohio metro county compared to a non-metro county on employment and financial concerns.

Methods: We conducted a survey between June and November 2020 and collected participants' demographics, employment status, perceived financial status, and health-related conditions.

Identifying and breaking barriers: Addressing disparities in the care of patients with gynecologic cancers.

Background: Significant disparities exist in the care of patients with gynecologic malignancies. Higher incidences of gynecologic malignancies among underrepresented subpopulations (eg, racial, ethnic, and/or LGBTQAI+) and lack of representative enrollment within clinical trials have highlighted the need to improve healthcare equity. We aimed to identify barriers to equitable health care and clinical trial participation for specific diverse populations of patients with gynecologic malignancies and to identify potential solutions for overcoming these barriers.

The Association Between Product Attributes and Oral Nicotine Pouch (ONP) Preference - Evidence from Online Stores.

Introduction: Oral nicotine pouches (ONPs) have steadily gained popularity since first appearing in the U.S. market during 2014, but research on how their features are associated with consumer preference remains limited.

Comparing the Accuracy of Different Wearable Activity Monitors in Patients With Lung Cancer and Providing Initial Recommendations: Protocol for a Pilot Validation Study.

Background: Wearable activity monitors (WAMs) provide insights into physical activity (PA) and are widely used in behavioral interventions and cancer survivorship research. However, validation studies of wearable devices in populations with cancer are scarce, and existing studies using activity monitors in patients with cancer lack standardization. This gap is particularly significant in patients with lung cancer (LC), who often experience unique mobility challenges and gait impairments that may affect device accuracy.

Association of Cancer History with COVID-19 Risk and Outcomes among Older Postmenopausal Women: Results from the Women's Health Initiative.

Background: Several studies early in the COVID-19 pandemic suggested that those with a cancer history had a higher risk of COVID-19 infections and complications. However, few prospective studies evaluated the association of cancer with COVID-19 in older women. We aimed to examine the association of cancer history with the risk of COVID-19 and various COVID-19 outcomes among older women.

Perceptions of COVID-19 risk among individuals with preexisting health conditions.

Objectives: To examine the association between the presence of preexisting health conditions (PEC) and the perceived risk of catching COVID-19 at the beginning of the pandemic and assess how risk perceptions changed over time.

Methods: We used data collected as part of the "Impact of COVID-19" baseline and follow-up surveys to complete our analyses. Participants were interviewed to collect their perceptions of the risk of catching COVID-19 (baseline and follow-up) and the number and type of PEC.

A Randomized Control Trial of Two Interventions Compared with Usual Care for Increasing Cervical Cancer Screening among Women Living in the Rural Midwest.

Background: Lower cervical cancer screening rates are associated with higher cervical cancer mortality among women living in rural compared with urban areas (defined by rural-urban community codes). The study purpose was to examine the effectiveness of a mailed digital video disc (DVD) versus DVD plus patient navigation (PN) versus usual care (UC) on increasing the percentage of rural women up to date (UTD) with cervical cancer screening guidelines.

Methods: Rural women (ages 50-74 years) who were not UTD for cervical cancer screening (n = 553) were consented and randomized 2:2:1 (DVD, DVD + PN, and UC, respectively).

Plasma Insulin-like Growth Factor-Binding Protein-7 Is Positively Associated with Age, Obesity, Mortality, and Cancer in Postmenopausal Women.

Background: Predictors of premature death and cancer development are needed to more precisely identify individuals who may warrant preventive intervention. Circulating insulin-like growth factor (IGF)-binding protein-7 (IGFBP7) and, to a lesser extent, the IGFBP7/IGF-1 ratio are emerging biomarkers of renal and cardiovascular morbidity. However, their relationships with aging, obesity, mortality, and cancer risk remain unclear.

COVID-19 vaccination uptake in Ohio: analyzing the difference between metro and non-metro residents.

Background: The COVID-19 pandemic resulted in the rapid development and distribution of vaccines as a critical strategy to control the spread of the virus. This paper explores COVID-19 vaccine uptake in the state of Ohio, with a particular focus on the difference between metro and non-metro residents.

Method: Survey data collected as part of the IMPACT-Ohio Project were used for this study.

The Association of Long COVID-19 Symptoms, Physical Function, and Activities of Daily Living Among Older Women.

Background: The impact of COVID-19 on physical function (PF) outcomes among older adults remains unclear. We examined the long-term association between COVID, PF, and Activities of Daily Living (ADLs) among women from the Women's Health Initiative (WHI).

Methods: Participants from the WHI who completed the COVID-19 survey (2021-2022) and annual survey (2022) were included.

Social isolation and cancer care delay during COVID-19 in LGBTQI+ cancer survivors.

Objective: Lesbian, gay, bisexual, transgender, queer, intersex, and people with other diverse sexual orientations and gender identities (LGBTQI+) experience higher levels of social isolation and delayed cancer screenings, diagnosis, and treatment compared with their non-LGBTQI+ counterparts. The purpose of this study was to examine the association between perceived social isolation (PSI) and delay of cancer screenings, follow-up, or treatment during the coronavirus disease 2019 (COVID-19) pandemic among LGBTQI+ cancer survivors, and to determine if this association varied by race and ethnicity.

Method: Data from the National LGBT Cancer Network's OUT: The National Cancer Survey were used.

The mediating role of social support in behavioral changes and weight loss outcomes among overweight Appalachian adults.

Social support plays a key role in behavioral changes, especially in Appalachian populations. We examined the mediating effect of social support in behavioral changes and corresponding weight loss outcomes among Appalachian adults. Data were from a group-randomized trial that compared a 12-month faith-based weight loss intervention to an active control group among overweight Appalachian adults in churches.

Cancer-related health behaviors during the COVID 19 pandemic in geographically diverse samples across the US.

Background: The COVID-19 pandemic involved business closures (e.g., gyms), social distancing policies, and prolonged stressful situations that may have impacted engagement in health behaviors.

Analysis of Physical Activity Using Wearable Health Technology in US Adults Enrolled in the All of Us Research Program: Multiyear Observational Study.

Background: To date, no studies have examined adherence to the 2018 Physical Activity Guidelines for Americans (PAGA) in real-world longitudinal settings using objectively measured activity monitoring data. This study addresses this gap by using commercial activity monitoring (Fitbit) data from the All of Us dataset.

Objective: The primary objectives were to describe the prevalence of adherence to the 2018 PAGA and identify associated sociodemographic determinants.

Harmonizing data across the accelerating colorectal cancer screening and follow-up through implementation science (ACCSIS) program to enhance data quality and promote data sharing.

Background: The purpose of the Accelerating Colorectal Cancer Screening and Follow-up through Implementation Science (ACCSIS) Program, a Cancer Moonshot℠ Initiative, is to support research to build the evidence base on multilevel interventions that increase rates of colorectal cancer screening, follow-up, and referral to care to address disparities in colorectal cancer screening. The National Cancer Institute funded eight Research Projects to implement multilevel interventions to improve colorectal cancer screening among communities who traditionally have been medically underserved. To analyze the impact of ACCSIS across Research Projects, the consortium developed a set of common data elements.

Changes in anthropometry, adiposity, and inflammation in Black and White women engaged in intentional weight loss.

Objective: We examined associations among changes in anthropometry, regional adiposity, and inflammatory markers in Black and White women participating in intentional weight loss.

Methods: A total of 104 women with BMI ≥ 25 kg/m self-selected bariatric surgery (n = 66) or a diet and exercise program (n = 38). Anthropometric, dual-energy x-ray absorptiometry-quantified regional adiposity, and inflammatory markers (C-reactive protein [CRP], tumor necrosis factor α [TNF-α], soluble TNF receptor I [sTNFRI], sTNFRII, interleukin [IL]-6, and soluble IL-1 receptor antagonist) were measured at baseline and 6 months.

Evidence-based recommendations regarding risk reduction practices for people at risk of or with breast cancer-related lymphedema: consensus from an expert panel.

Several recent studies have investigated the validity of precautionary practices for lymphedema risk reduction after breast cancer treatment, such as avoidance of blood pressure measurements, skin puncture, blood draws, and use of prophylactic compression during air travel. Other studies have elucidated risk factors for breast cancer-related lymphedema, such as axillary lymph node dissection and skin infection (cellulitis). Combining the current evidence base with the consensus opinion of lymphatic experts assembled at the American Cancer Society/Lymphology Association of North America Summit in October 2023, updated evidence-based risk reduction recommendations are presented for those with or at risk of breast cancer-related lymphedema.

The influence of non-cancer-related risk factors on the development of cancer-related lymphedema: a rapid review.

Extensive research supports an evidence-base for cancer treatment-related risk factors, including extent of lymph node dissection and use of radiotherapy, as contributing to secondary lymphedema. Additionally, comorbidities, such as higher body mass index, and vascular-related conditions are identified to further augment risk. While social determinants of health (SDOH) and socioeconomic factors are widely regarded as influencing an individual's healthcare outcomes, including cancer risk and survival, these factors have not been explored as risk factors for developing secondary lymphedema.