Structural characterization of macro domain-containing Thoeris antiphage defense systems.

Thoeris defense systems protect bacteria from infection by phages via abortive infection. In these systems, ThsB proteins serve as sensors of infection and generate signaling nucleotides that activate ThsA effectors. Silent information regulator and SMF/DprA-LOG (SIR2-SLOG) containing ThsA effectors are activated by cyclic ADP-ribose (ADPR) isomers 2'cADPR and 3'cADPR, triggering abortive infection via nicotinamide adenine dinucleotide (NAD) depletion.

[An appraisal of healthcare mobile applications].

Mobile applications (Apps) may become effective aids in health care. Health Apps could reduce barriers such as access and costs and could be used to monitor symptoms, behaviors and even treatments. There is more evidence of their usefulness in nutrition, cardiovascular and mental health.

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling.

Cyclic adenosine diphosphate (ADP)-ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide adenine dinucleotide (oxidized form) (NAD) hydrolysis. We show that v-cADPR (2'cADPR) and v2-cADPR (3'cADPR) isomers are cyclized by O-glycosidic bond formation between the ribose moieties in ADPR. Structures of 2'cADPR-producing TIR domains reveal conformational changes that lead to an active assembly that resembles those of Toll-like receptor adaptor TIR domains.

Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.

The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon degeneration and a therapeutic target for several neurodegenerative conditions. We show that a potent SARM1 inhibitor undergoes base exchange with the nicotinamide moiety of nicotinamide adenine dinucleotide (NAD) to produce the bona fide inhibitor 1AD. We report structures of SARM1 in complex with 1AD, NAD mimetics and the allosteric activator nicotinamide mononucleotide (NMN).

[Healthy lifestyles in times of pandemic].

SARS-CoV-2 pandemic generated a profound impact on people's health, emphasizing the relevance of healthy lifestyles. Recommendations on how to maintain adequate physical activity, diet, sleep and social connection have been issued. However, it is worth expanding our look to other possible elements related to lifestyles such as the relationship with technology, nature, pets and music.

The object of my aggression: Sexual objectification increases physical aggression toward women.

Objectification involves reducing someone to a sexual object, rather than seeing them as a full person. Despite numerous theoretical claims that people are more aggressive toward the objectified, and empirical evidence that objectification is linked to high willingness to aggress, rape proclivity, and aggressive attitudes, no research has examined a causal link between objectification and physical aggression, particularly in the context of provocation. In two experiments, we examined this predicted link.

Too (mentally) busy to chill: Cognitive load and inhibitory cues interact to moderate triggered displaced aggression.

Inhibitory information can be expected to reduce triggered displaced aggression by signaling the potential for negative consequences as a result of acting aggressively. We examined how cognitive load might interfere with these aggression-reducing effects of inhibitory cues. Participants (N = 80) were randomly assigned to a condition in a 2 (cognitive load: high/low) × 2 (inhibiting cues: yes/no) between-subjects design.

Validity and reliability of the Spanish version of the Displaced Aggression Questionnaire.

Background:  The Displaced Aggression Questionnaire (DAQ) is an instrument that assesses personality differences in the tendency to displace aggression. This scale is composed of three factors: angry rumination (as affective dimension), revenge planning (as cognitive dimension), and general tendency to engage in displaced aggression (as a behavioral dimension). The present study examined the validity and reliability of the Spanish version of the DAQ.

Any of them will do: In-group identification, out-group entitativity, and gang membership as predictors of group-based retribution.

In non-gang populations, the degree of identification with an in-group and perceptions of out-group entitativity, the perception of an out-group as bonded or unified, are important contributors to group-based aggression or vicarious retribution. The link between these factors and group-based aggression, however, has not been examined in the context of street gangs. The current study assessed the relationship among in-group identification, perceptions of out-group entitativity, and the willingness to retaliate against members of rival groups who did not themselves attack the in-group among juvenile gang and non-gang members in London.

Are You Insulting Me? Exposure to Alcohol Primes Increases Aggression Following Ambiguous Provocation.

Considerable research has shown that alcohol consumption can increase aggression and produce extremes in other social behaviors. Although most theories posit that such effects are caused by pharmacological impairment of cognitive processes, recent research indicates that exposure to alcohol-related constructs, in the absence of consumption, can produce similar effects. Here we tested the hypothesis that alcohol priming is most likely to affect aggression in the context of ambiguous provocation.

The animal in you: animalistic descriptions of a violent crime increase punishment of perpetrator.

Criminal acts are sometimes described using animal metaphors. What is the impact of a violent crime being described in an animalistic versus a non-animalistic way on the subsequent retribution toward the perpetrator? In two studies, we experimentally varied animalistic descriptions of a violent crime and examined its effect on the severity of the punishment for the act. In Study 1, we showed that compared to non-animalistic descriptions, animalistic descriptions resulted in significantly harsher punishment for the perpetrator.

An evaluation of mandatory polygraph testing for sexual offenders in the United kingdom.

This research examined whether a government-initiated pilot project of mandatory polygraph testing would increase the disclosures made by community-supervised sexual offenders in the United Kingdom. The Offender Managers of 332 pilot polygraph sexual offenders and 303 sexual offenders who were receiving usual community supervision were telephoned quarterly, over a 21-month period, to collect information about numbers of clinically relevant disclosures, the seriousness of disclosures made, and actions taken as a result of disclosures. Perceptions of polygraph usefulness were also collected.

Lashing out after stewing over public insults: the effects of public provocation, provocation intensity, and rumination on triggered displaced aggression.

Four studies present the first evidence showing that public (vs. private) provocation augments triggered displaced aggression by increasing the perceived intensity of the provocation. This effect is shown to be independent of face-saving motivation.

Rumination and the displacement of aggression in United Kingdom gang-affiliated youth.

The concept of gang aggression oftentimes elicits images of brutal intergang violence. In reality, gang-related aggression can vary widely, can have various motivations and causal factors, and includes interpersonal as well as intergroup aggression. This study examined the tendency of UK youth to engage in displaced aggression (aggression aimed at undeserving targets) and examined the relationship among gang affiliation, ruminative thought, and aggression levels.

The impact of rumination on aggressive thoughts, feelings, arousal, and behaviour.

Although rumination following a provocation can increase aggression, no research has examined the processes responsible for this phenomenon. With predictions derived from the General Aggression Model, three experiments explored the impact of two types of post-provocation rumination on the processes whereby rumination augments aggression. In Experiment 1, relative to distraction, self-focused rumination uniquely increased the accessibility of arousal cognition, whereas provocation-focused rumination uniquely amplified the accessibility of aggressive action cognition.

Kicking the (barking) dog effect: the moderating role of target attributes on triggered displaced aggression.

Sometimes aggression is displaced onto a target who is not totally innocent but emits a mildly irritating behavior called a triggering event. In three experiments, the authors examine stable personal attributes of targets that can impact such triggered displaced aggression (TDA). Lower levels of TDA were directed to targets whose attitudes were similar as compared to dissimilar to those of the actor (Experiment 1) and to targets who were ingroup as compared to out-group members (Experiment 2).

The impact of aggressive priming, rumination, and frustration on prison sentencing.

We tested the hypothesis that ruminating about a previous aggressive prime interacts with a subsequent minor frustration to augment aggression. Sixty participants watched a video showing a murder during a bank robbery (the aggressive prime). Those in the rumination condition were asked to write about the video for 20 min.

The effects of alcohol and the salience of aggressive cues on triggered displaced aggression.

Alcohol increases the aggression-augmenting effects of provocation. Theories of alcohol and aggression suggest that impaired cognitive processing induced by acute intoxication leads individuals to process aggression-inducing social cues differently depending on whether they are high or low in salience. We examined the effects of intoxication and aggressive cue salience within the triggered displaced aggression paradigm.

Chewing on it can chew you up: effects of rumination on triggered displaced aggression.

Ruminating about a provocation increases the likelihood of displaced aggression following a minor annoyance (trigger). In Study 1, provoked participants who ruminated for 25 min were more aggressive toward a fumbling confederate than were distracted participants. Provocation-induced negative affect was positively related to aggression but only among those who ruminated.

Volume of pleural fluid required for diagnosis of pleural malignancy.

Study Objectives: To determine if the diagnosis of pleural malignancy is dependent on the volume of pleural fluid sampled.

Design And Setting: Single-center retrospective chart review.

Patients: Two hundred eighty-two patients who underwent diagnostic thoracentesis between October 1, 1998, and June 30, 1999.