Absence of Deep and Basal Veins Is Common and Clinically Relevant in Sturge-Weber Syndrome.

Background: Common intracranial vascular abnormalities in Sturge-Weber syndrome (SWS) include leptomeningeal venous malformations (LVMs) and enlarged deep veins. A few small studies have reported absent deep veins in some patients. We used susceptibility-weighted imaging (SWI), a magnetic resonance imaging (MRI) sequence sensitive to detecting small veins, to evaluate deep cerebral veins and the basal vein of Rosenthal (BVR) and assess the radiological correlates and clinical impact of their absence.

GABA outperforms iron and neuromelanin in detecting nigrostriatal alterations in early-stage Parkinson's disease with RBD.

This study aimed to examine variations in iron deposition, neuromelanin (NM) content, gamma-aminobutyric acid (GABA) and glutamate-glutamine complex (Glx) levels within the nigrostriatal pathway in early-stage Parkinson's disease (PD) patients with and without Rapid Eye Movement Sleep Behavior Disorder (RBD). Twenty-two early-stage PD patients with RBD (PD-RBD), 33 without RBD (PD-nRBD), and 36 healthy controls (HC) were prospectively recruited and underwent 3 T MRI and H-MRS scans. GABA levels in the left basal ganglia were elevated in PD-nRBD versus HC (P = 0.

Association between deep gray matter iron deposition, white matter hyperintensity, and hypertensive cognitive impairment.

Background: Deep gray matter (DGM) iron deposition and white matter hyperintensity (WMH) often occur simultaneously in hypertensive patients. However, their relationship and effect on cognition in hypertension remain unclear. We aimed to investigate the correlation between DGM iron deposition, WMH, and cognitive impairment.

Cardiac magnetic resonance-derived extracellular volume radiomics in reperfused ST-elevation myocardial infarction: long-term prognostic value and risk stratification.

Aims: Global extracellular volume (ECV) fraction independently predicts outcomes after ST-elevation myocardial infarction (STEMI), but microvascular injuries complicate its interpretation. This study aims to assess the prognostic value of ECV-derived radiomics [radiomics score (RadScore)] from cardiac magnetic resonance (CMR) for risk stratification in reperfused STEMI patients.

Methods And Results: We retrospectively included 441 reperfused STEMI patients (mean age 60 ± 11 years; 371 males) from two centres, divided into development (n = 347) and validation cohort (n = 94) by centres.

Vascular Contribution to Cerebral Waste Clearance Affected by Aging or Diabetes.

The brain's vascular system has recently been shown to provide an important efflux pathway for cerebral waste clearance (CWC). However, little is known about the influence of aging or diabetes on the CWC. The aim of the current study is to investigate the vasculature contribution to CWC under aging and diabetic conditions.