The influence of prenatal exercise modes on resting maternal blood lactate.

Resting lactate concentration in venous blood is a commonly used indicator of metabolic disease risk. Regular exercise during pregnancy improves maternal metabolic health; however, it is unknown if maternal exercise regulates resting lactate concentration. We aimed to elucidate the effects of three different modalities of exercise during pregnancy on blood lactate in pregnant women.

Exercise FITT-V during pregnancy: 1-month infant neuromotor outcomes.

Background: Despite decades of research documenting health benefits from exercise during pregnancy, it remains unknown how prenatal exercise affects infant neuromotor skill development.

Objectives: To examine the effects of exercise modes, and maternal exercise metrics; frequency, intensity, time, type, and volume (FITT-V) during pregnancy on infant gross motor skills. We hypothesized that 1 month old infants of mothers who exercised during pregnancy would exhibit more developed gross motor skills compared to infants of mothers who did not exercise during pregnancy.

Prenatal exercise regulates influence of parental body mass index on birth outcomes.

Background: Offspring body mass index is often higher in parents with overweight or obesity, thereby increasing the risk of obesity later in life. As data has shown that exercise during pregnancy reduces gestational weight gain and offspring adiposity, we believe the intergenerational risk of obesity could be reduced.

Objective: This study aimed to test the influence of paternal and maternal overweight or obesity on neonatal body mass index and other birth measures, and whether exercise during pregnancy would improve outcomes.

Impact of Supervised-concurrent Exercise During Pregnancy on Infant Neuromotor Skills: A Post-hoc Analysis Stratified by Maternal BMI.

Background: This is a post-hoc secondary analysis of a randomized controlled trial whose purpose was to analyze the effect of a supervised-combined aerobic and resistance exercise (concurrent exercise) training program during pregnancy on 1-month infant neuromotor skills based on maternal pre-pregnancy body mass index (BMI).

Methods: Ninety-four pregnant women participated in this study, which was conducted at East Carolina University (Greenville, North Carolina, USA) between 2015 and 2018, and were allocated into concurrent exercise (n = 42) or stretching and breathing group (n = 52). The exercise group followed a 50-min 3 days/week moderate intensity concurrent exercise training program from the 16th gestational week until birth.

Exercise during pregnancy (frequency, intensity, type, time, volume): birth outcomes in women at risk of hypertensive disorders of pregnancy.

Background: Hypertensive disorders of pregnancy (HDP) hold negative health implications for mothers and offspring. While the beneficial influence of prenatal exercise on reducing HDP risk has been previously shown, there is a lack of specific information on the effect on birth outcomes in at-risk women, and in-depth analysis of appropriate exercise dose is lacking.

Objective: We aimed to elucidate the effects of exercise training FITT-V (frequency, intensity, type, time, volume) on hypertension and birth outcomes in pregnant women.

Exercise during pregnancy Dose: Influence on preterm birth outcomes.

Background: Preterm delivery typically increases health risk for neonates and is associated with longer infant hospital stay and financial burden. Prenatal exercise dose (frequency, intensity, type, time, volume) have been shown to influence birth outcomes. Increased prenatal exercise dose could therefore provide a critical reduction in health risk and financial burden in preterm neonates.

Exercise FITT-V during pregnancy: Association with birth outcomes.

Background: Prenatal exercise improves birth outcomes, but research into exercise dose-response effects is limited.

Methods: This study is a retrospective, secondary analysis of pooled data from three blinded, prospective, randomized controlled trials. Prenatal exercise frequency, intensity, type, time, and volume (FITT-V) were assessed in supervised sessions throughout pregnancy.

Effects of Maternal Exercise Modes on Glucose and Lipid Metabolism in Offspring Stem Cells.

Context: Maternal exercise positively influences pregnancy outcomes and metabolic health in progeny; however, data regarding the effects of different modes of prenatal exercise on offspring metabolic phenotype is lacking.

Objective: To elucidate the effects of different modes of maternal exercise on offspring umbilical cord derived mesenchymal stem cell (MSC) metabolism.

Design: Randomized controlled trial.

Event Rates and Risk Factors for Recurrent Cardiovascular Events and Mortality in a Contemporary Post Acute Coronary Syndrome Population Representing 239 234 Patients During 2005 to 2018 in the United States.

Background Patients with acute coronary syndrome (ACS) are recognized by guidelines as remaining at high risk for adverse outcomes. Evidence from contemporary, representative ACS populations in a clinical practice setting is necessary to identify subgroups and strategies for improving patient outcomes. We aimed to describe event rates and risk factors in an ACS population over prolonged follow-up for cardiovascular end points.

Design and rationale for the supermarket and web-based intervention targeting nutrition (SuperWIN) for cardiovascular risk reduction trial.

Purpose: The prevalence of chronic diseases is increasing largely due to suboptimal dietary habits. It is not known whether individualized, supermarket-based, nutrition education delivered by registered dietitians, utilizing the advantages of the in-store and online environments, and electronically collected purchasing data, can increase dietary quality.

Methods And Results: The supermarket and web-based intervention targeting nutrition (SuperWIN) for cardiovascular risk reduction trial is a randomized, controlled dietary intervention study.

Evaluation of Mortality Data From the Social Security Administration Death Master File for Clinical Research.

Importance: Despite its documented undercapture of mortality data, the US Social Security Administration Death Master File (SSDMF) is still often used to provide mortality end points in retrospective clinical studies. Changes in death data reporting to SSDMF in 2011 may have further affected the reliability of mortality end points, with varying consequences over time and by state.

Objective: To evaluate the reliability of mortality rates in the SSDMF in a cohort of patients with atherosclerotic cardiovascular disease (ASCVD).

Lipid-lowering Therapy and Goal Achievement in High-risk Patients From French General Practice.

Purpose: The goal of this study was to summarize patterns of lipid-lowering therapy (LLT) usage and achievement of guideline-identified lipid goals in a 2015 general practice cohort of French patients with atherosclerotic cardiovascular disease (ASCVD) and/or diabetes mellitus (DM).

Methods: From the IMS Health Real-World Data database, patients aged ≥18years were classified hierarchically into mutually exclusive categories of ASCVD subgroups and DM. LLT use and lipid goal achievement were assessed on the date of lipid measurement.

Association of Fibroblast Growth Factor 23 With Recurrent Cardiovascular Events in Patients After an Acute Coronary Syndrome: A Secondary Analysis of a Randomized Clinical Trial.

Importance: Elevated fibroblast growth factor 23 (FGF-23) concentrations are associated with myocardial fibrosis and renin-angiotensin system upregulation, potentially providing prognostic information distinct from standard cardiovascular (CV) biomarkers.

Objective: To evaluate the association of FGF-23 with recurrent CV events in patients after an acute coronary syndrome (ACS).

Design, Setting, And Participants: C-terminal FGF-23 was measured in plasma samples using an established enzyme-linked immunosorbent assay system for 4947 patients within 30 days of ACS (median, 14 days) and with 1 additional CV risk factor in the Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52 (SOLID-TIMI 52) trial of the lipoprotein-associated phospholipase A2 inhibitor darapladib vs placebo performed from December 1, 2009, to April 24, 2014 (median follow-up, 2.

The effect of fasting status on lipids, lipoproteins, and inflammatory biomarkers assessed after hospitalization for an acute coronary syndrome: Insights from PROVE IT-TIMI 22.

Background: For decades, fasting for 8 to 12 hours has been recommended for measurement of lipid profiles. The effect of fasting on low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) has been described in healthy cohorts and those with stable disease states. Recently, guidelines suggested that fasting may not be necessary due to its small effect on lipid measures.

Atrial fibrillation decision support tool: Population perspective.

Background: Appropriate thromboprophylaxis for patients with atrial fibrillation or atrial flutter (AF) remains a national challenge. The recent availability of direct oral anticoagulants (DOACs) with comparable efficacy and improved safety compared with warfarin alters the balance between risk factors for stroke and benefit of anticoagulation. Our objective was to examine the impact of DOACs as an alternative to warfarin on the net benefit of oral anticoagulant therapy (OAT) in a real-world population of AF patients.