The impact of menstrual phase on lower limb microvascular function, ERα, eNOS and p-eNOS protein in premenopausal females.

There is variability in the impact of menstrual phase on microvascular function with some studies reporting an increase from the early follicular (EF) to late follicular (LF) phase. Estradiol (E2) may increase nitric oxide bioavailability and thereby microvascular function through increasing estrogen receptor alpha (ERα), endothelial nitric oxide synthase (eNOS), and phosphorylated eNOS (p-eNOS) protein. It is unknown whether variability in ERα, eNOS, and p-eNOS protein levels drives menstrual cycle-related changes in microvascular endothelial function.

Altered sphingolipid profile in response to skeletal muscle injury in a mouse model of type 1 diabetes mellitus.

A complication of type 1 diabetes mellitus (T1DM) is diabetic myopathy that includes reduced regenerative capacity of skeletal muscle. Sphingolipids are a diverse family of lipids with roles in skeletal muscle regeneration. Some studies have found changes in sphingolipid species levels in T1DM, however, the effect of T1DM on a sphingolipid panel in regenerating skeletal muscle has not been examined.

Augmented mitochondrial apoptotic signaling impairs C2C12 myoblast differentiation following cellular aging through sequential passaging.

Aging is associated with the steady decline of several cellular processes. The loss of skeletal muscle mass, termed sarcopenia, is one of the major hallmarks of aging. Aged skeletal muscle exhibits a robust reduction in its regenerative capacity due to dysfunction (i.