Differential Effects of Losartan and Finerenone on Diabetic Remodeling, Oxidative Stress and ACE Activity in the Gastrointestinal Tract of Streptozotocin-Induced Diabetic Rats.

Gastrointestinal (GI) complications are common in diabetes, but the role of the local renin-angiotensin-aldosterone system (RAAS) in gut remodeling remains unclear. This study examined histomorphometric alterations, oxidative stress, and systemic and tissue-specific angiotensin converting enzyme (ACE) and ACE2 activity in streptozotocin (STZ)-induced diabetic rats. Adult male Wistar rats ( = 24) were assigned to control (CTRL), diabetic (STZ), and diabetic groups treated with losartan (STZ-LOS, 20 mg/kg/day) or finerenone (STZ-FIN, 10 mg/kg/day).

The ecological dynamics of cognizant action in sport.

The widespread inferential understanding of human action attributes to the brain the power of modelling actions and predicting immediate changes in environmental circumstances. However, an ecological rationale proposes that sport performance is founded on coupled perception and action, avoiding the need for the brain, as a mediator, to be lagging behind immediate corporeal contact with the sport environment. Here, a theory of cognizant action is presented where behaviour is understood in terms of self-organized action, shaped by a performer's complex skills, directed towards perceived affordances.

Exploring Gastrointestinal Health in Diabetic Cats: Insights from Owner Surveys, Ultrasound, and Histopathological Analysis.

Diabetes is a metabolic disorder characterized by chronic hyperglycemia, affecting between 0.21% and 1.24% of cats.

Towards an ecological dynamics theory of flow in sport.

Flow is an optimal state of absorption that may be experienced in appropriately challenging and intrinsically motivating activities such as sports. Flow may be an important concept for understanding the emergence and role of sport in society, yet theoretical explanations of flow have had limited success explaining, predicting, and facilitating flow in sport. Here, we use the ecological dynamics framework, seeking to resolve foundational issues in an explanation of flow, building towards a theory of flow in sport.

Oxidative Stress and Histomorphometric Remodeling: Two Key Intestinal Features of Type 2 Diabetes in Goto-Kakizaki Rats.

Gastrointestinal complications of diabetes are often overlooked, despite affecting up to 75% of patients. This study innovatively explores local glutathione levels and morphometric changes in the gut of Goto-Kakizaki (GK) rats, a type 2 diabetes animal model. Segments of the intestine, cecum, and colon were collected for histopathological analysis and glutathione quantification.

The Finishing Space Value for Shooting Decision-Making in High-Performance Football.

Football players' decision-making behaviours near the scoring target (finishing situations) emerge from the evolving spatiotemporal information directly perceived in the game's landscape. In finishing situations, the ball carrier's decision-making about shooting or passing is not an decision-making process, but a decision that is guided by players' perceptions of match affordances. To sustain this idea, we collected spatiotemporal information and built a model to quantify the "Finishing Space Value" (FSV) that results from players' perceived affordances about two main questions: (a) is the opponent's target successfully from a given pitch location?; and (b) from each given pitch location, the opposition context will allow space to shoot (low adversaries' interference)? The FSV was calculated with positional data from high-performance football matches, combining information extracted from Voronoi diagrams (VD) with distances and angles to the goal line.

On finding one's way: a comment on Bock et al. (2024).

In a recent issue of Psychological Research, Bock, O., Huang, J-Y., Onur, O.

Understanding the visual search strategies of expert and novice coaches in futsal set pieces.

Introduction: This study aimed to describe the fixation location and the time of the longer fixation of expert and novice futsal coaches before the ball was in play in futsal set pieces.

Methods: A total of 10 experts (ages 48 ± 5) and 10 novice coaches (ages 40 ± 7) participated in the study. They observed that 38 video clips were created to mimic the attack and defensive set-piece moments of the game.

Angiotensin-converting enzymes 1 and 2 in the feces: presence and catalytic activity in the rat 2,4,6-trinitrobenzene sulfonic acid-induced model of colitis.

Background And Aim: Inflammatory bowel disease is challenging to diagnose. Fecal biomarkers offer noninvasive solutions. The renin-angiotensin-aldosterone system is implicated in intestinal inflammation.

The effects of nature-based vs. indoor settings on the adaptability, performance and affect of calisthenics exercisers. A registered report.

Comparisons of the beneficial effects of nature-based versus indoor physical activity have been extensively reported, but existing research addresses mainly aerobic activity (running, jogging), not resistance or mixed (aerobic and resistance) exercise. It is unclear if the psychological benefits extend to functionality, i.e.

On a Corresponsive Sport Science.

In our societally extractive age, sport science risks being swept up in the intensifying desire to commodify the experiences of those that scientists proclaim to study. Coupled with the techno-digital revolution, this stems from a vertical (onto)logic that frames the sporting landscape as a static space filled with discrete objects waiting for us to capture, analyse, re-present and sell on as knowledge. Not only does this commodification degrade primary experience in the false hope of epistemological objectivity, it reinforces the unidirectionality of extractivism by setting inquirer apart from, and above of, inquiry.

The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time.

Doxorubicin (DOX) is a topoisomerase II inhibitor used in cancer therapy. Despite its efficacy, DOX causes serious adverse effects, such as short- and long-term cardiotoxicity. This work aimed to assess the short- and long-term cardiotoxicity of DOX and the role of inflammation and antioxidant defenses on that cardiotoxicity in a mice model.

Rats prefer condensed milk to strawberry jam - a new possibility for voluntary oral drug administration.

Voluntary oral drug administration using sweet substances promotes rodents' therapeutic compliance while reducing stress induced by forced drug administration. We aimed to test whether rats would willingly eat strawberry jam or condensed milk from a syringe, and which one they would prefer. Our results show that rats prefer condensed milk, demonstrating its potential as a vehicle for the voluntary oral administration of drugs in experimental protocols.

Perceived self-efficacy by Under-10 tennis players when scaling the equipment and play area.

The modification of child-sports aims to develop an optimal learning environment that facilitates the emergence of desirable psychological outcomes (e.g., self-efficacy).

Heterogeneity in protocols and outcomes to study the effect of renin-angiotensin system blockers in inflammatory bowel disease: A systematic review.

Background: The renin-angiotensin system (RAS) has been associated with inflammatory bowel disease (IBD), supporting translational relevance of RAS blockers. Comparability of study design/outcomes is fundamental for data analysis/discussion.

Objectives: We aimed at evaluating the heterogeneity among protocols and outcomes to study the effect of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in IBD.

Cardiac Molecular Remodeling by Anticancer Drugs: Doxorubicin Affects More Metabolism While Mitoxantrone Impacts More Autophagy in Adult CD-1 Male Mice.

Doxorubicin (DOX) and mitoxantrone (MTX) are classical chemotherapeutic agents used in cancer that induce similar clinical cardiotoxic effects, although it is not clear if they share similar underlying molecular mechanisms. We aimed to assess the effects of DOX and MTX on the cardiac remodeling, focusing mainly on metabolism and autophagy. Adult male CD-1 mice received pharmacologically relevant cumulative doses of DOX (18 mg/kg) and MTX (6 mg/kg).

Ubiquitous skill opens opportunities for talent and expertise development.

In this article we aim to define and present the complementary nature of talent, skill and expertise. Human daily life is replete with expressions of skillful behaviours while interacting with the world, which in specific socio-culturally defined domains, such as sport and work, demand a specialization of such ubiquitous skill. Certain manifestations of ubiquitous skill are identified by experts from the specialized domain of sport with the label of "talent".

ACE and ACE2 catalytic activity in the fecal content along the gut.

Background: Angiotensin-converting enzyme (ACE) and ACE2 are two major enzymes of the renin-angiotensin-aldosterone system (RAAS), which control the formation/degradation of angiotensin (Ang) II and Ang1-7, regulating their opposite effects. We aimed at evaluating the catalytic activity of ACE and ACE2 in the intestinal content and corresponding intestinal tissue along the gut of Wistar Han rats.

Methods: Portions of the ileum, cecum, proximal colon, and distal colon, and the corresponding intestinal content were collected from Wistar Han rats.

From Optical Tracking to Tactical Performance via Voronoi Diagrams: Team Formation and Players' Roles Constrain Interpersonal Linkages in High-Level Football.

Football performance behaviour relies on the individual and collective perceptual attunement to the opportunities for action (affordances) available in a given competitive environment. Such perception-action coupling is constrained by players' spatial dominance. Aiming to understand the influence of team formation and players' roles in their dynamic interaction (interpersonal linkages), Voronoi diagrams were used to assess the differences in players' spatial dominance resulting from their interactions according to ball-possession status in high-performance football.

Histomorphometry Changes and Decreased Reactivity to Angiotensin II in the Ileum and Colon of Streptozotocin-Induced Diabetic Rats.

Diabetes mellitus (DM) is a chronic progressive metabolic disorder associated with several gastrointestinal complications, affecting up to 75% of patients. Knowing that Angiotensin II (AngII) also regulates intestinal contraction, we decided to evaluate changes in ileum and colon histomorphometry and AngII reactivity in a rat model of DM. Streptozotocin (STZ, 55 mg/kg) was administered to induce DM to 24 adult male Wistar rats.

An ecological dynamics perspective on designing urban nature environments for wellbeing and health-enhancing physical activity.

The latest World Health Organization report on green and blue space and mental health (2021) calls for greater, and better, urban nature environments, i. e., "wilder" urban parks, tree-laden sidewalks, and overall presence of nature in the urban environment.

Joining with the Conversation: Research as a Sustainable Practice in the Sport Sciences.

What would it mean to consider research in the sport sciences as a sustainable practice? Taking a step back, in such a context, what would sustainability even mean? The time is ripe to address such questions, and what we lay out here are our initial thoughts on this most contemporary of issues. We start by exploring what is meant by the term 'sustainability'. Rather than following mainstream thinking-the harnessing of earthly resources commodified and exploited as 'renewables'-we situate it in the sport sciences as a continuing response-ability to the experiences of others.

Match Analysis in Team Ball Sports: An Umbrella Review of Systematic Reviews and Meta-Analyses.

Background: Match analysis has evolved exponentially over the past decades in team sports resulting in a significant number of published systematic reviews and meta-analyses. An umbrella review of the available literature is needed to provide an integrated overview of current knowledge and contribute to more robust theoretical explanations of team performance.

Methods: The Web of Science (all databases), PubMed, Cochrane Library (Cochrane Database of Systematic Reviews), Scopus, and SPORTDiscus databases were searched for relevant publications prior to 19 February 2021.