Optimizing wind turbine blade pitch control via input output differential model free adaptive control.

In the context of wind energy systems, maintaining optimal power output in wind turbines when wind speeds exceed rated values necessitates precise regulation of blade pitch through the pitch control system. However, challenges in accurately modeling nonlinear control systems and enhancing control responsiveness arise due to factors such as actuator constraints, unmodeled dynamics, and random wind speed fluctuations. This paper proposes an improved model free control, termed Input Output Model Free Adaptive Control (IO-MFAC).

The diverse effects of cisplatin on tumor microenvironment: Insights and challenges for the delivery of cisplatin by nanoparticles.

Cisplatin is a well-known platinum-based chemotherapy medication that is widely utilized for some malignancies. Despite the direct cytotoxic consequences of cisplatin on tumor cells, studies in the recent decade have revealed that cisplatin can also affect different cells and their secretions in the tumor microenvironment (TME). Cisplatin has complex impacts on the TME, which may contribute to its anti-tumor activity or drug resistance mechanisms.

The interactions of paclitaxel with tumour microenvironment.

Today, it is well-known that the interactions and secretion within the tumour are crucial to consider for cancer therapy. Some novel cancer therapy modalities such as immunotherapy or tumour vaccination therapy work based on the control of interactions within the tumour microenvironment (TME). It has been revealed that anti-cancer drugs or radiotherapy can modulate some interactions in favour of cancer therapy.