Publications by authors named "Dimitri Chartoire"
Article Synopsis
- * Researchers found that knocking out BTG1 increases the severity of the disease, especially when paired with Bcl2 overexpression.
- * Additionally, they identified a partnership between BTG1 and the protein BCAR1, leading to enhanced cell migration when BTG1 is mutated or deleted, which can potentially be treated with SRC inhibitors like dasatinib.
Article Synopsis
- - Peripheral T cell lymphomas (PTCLs) have poor clinical outcomes and are linked to chronic T cell receptor (TCR) activation, but their exact mechanisms are not well understood.
- - Research using a mouse model shows that while chronic TCR stimulation can lead to the development of PTCLs, it does not help their survival; instead, PTCLs reprogram to adopt characteristics similar to natural killer (NK) cells, expressing NK cell receptors (NKRs) and relying on specific signaling pathways.
- - Analysis of human PTCL cases indicates that a similar reprogramming occurs, prompting the need for clinical studies targeting molecules like SYK and NKRs to potentially improve treatment outcomes for this aggressive cancer.
Article Synopsis
- - Mesenchymal stem cells from adipose tissue have immunosuppressive properties and may play a role in cell therapy, but their effects on early obesity-related inflammation were not previously understood.
- - A study using mice on a high-fat diet revealed distinct responses from adipose stem cells (ASC) in different fat areas: subcutaneous ASC inhibited T cell growth, while visceral ASC reduced TNFα in macrophages and increased IL6 production.
- - These findings suggest that ASC behave as metabolic sensors, adapting to obesity conditions and influencing inflammation differently based on their location in the body, potentially affecting the onset of obesity-related inflammation.
Clinical outcome in antibody-mediated rejection (AMR) shows high inter-individual heterogeneity. Sialylation status of the Fc fragment of IgGs is variable, which could modulate their ability to bind to C1q and/or Fc receptors. In this translational study, we evaluated whether DSA sialylation influence AMR outcomes.
View Article and Find Full Text PDFAntibody-mediated rejection is currently the leading cause of transplant failure. Prevailing dogma predicts that B cells differentiate into anti-donor-specific antibody (DSA)-producing plasma cells only with the help of CD4+ T cells. Yet, previous studies have shown that dependence on helper T cells decreases when high amounts of protein antigen are recruited to the spleen, two conditions potentially met by organ transplantation.
View Article and Find Full Text PDFAdoptive cell therapy represents a promising approach for several chronic diseases. This study describes an innovative strategy for biofunctionalization of nanoparticles, allowing the generation of synthetic particulate antigens (SPAg). SPAg activate polyclonal B cells and vectorize noncognate proteins into their endosomes, generating highly efficient stimulators for ex vivo expansion of antigen-specific CD4+ T cells.
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