Publications by authors named "Diego Santiago Fernandez Romero"
Objective: The first aim was to retrospectively identify risk factors for the development of early severe preeclampsia (sPE) in patients with obstetric antiphospholipid syndrome (OAPS) who received conventional treatment (CT). The second aim was to evaluate the impact of hydroxychloroquine (HCQ) in preventing early sPE among a subgroup of patients considered at high risk.
Methods: A total of 102 women diagnosed with OAPS and treated with CT since the diagnosis of pregnancy were selected.
A high-risk laboratory profile of antiphospholipid antibodies and thrombosis is associated with a large number of extra-criteria manifestations in obstetric antiphospholipid syndrome.
Sebastián Udry
,
José Omar Latino
,
Cristina Belizna
,
Silvia Perés Wingeyer
,
Diego Santiago Fernández Romero
Immunol Res
December 2019
Article Synopsis
- Extra-criteria manifestations like thrombocytopenia and livedo are linked to antiphospholipid syndrome (APS) but are not included in current classification guidelines.
- A study of 79 women diagnosed with primary obstetric antiphospholipid syndrome (POAPS) found that those with three or more extra-criteria manifestations had significantly high levels of antiphospholipid antibodies (aPL) and higher risk for thrombosis during a follow-up period averaging five years.
- The research indicates that patients with extra-criteria manifestations are more likely to have a high-risk aPL profile and may be at greater risk for developing thrombosis, as observed since all patients with thrombotic events had at least three of these symptoms.