Publications by authors named "Dias Argandykov"

Background: The quantitative effect of frailty on post-operative complications in older adults undergoing surgical emergencies is not well understood.

Methods: The 2013-2019ACS-NSQIP database was used to identify emergency laparotomy patients≥65 years. Frailty was measured using the modified-frailty-index-5 factors (mFI-5).

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Objective: Although data concerning resident involvement in emergency general surgery (EGS) procedures is abundant, its impact on outcomes in the vulnerable older adult population has not been explored. This study aimed to assess the impact of resident involvement on postoperative outcomes in older adult patients undergoing EGS.

Design: Propensity-score matched cohort study.

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Background: Affiliations between community and academic hospitals are increasing. However, their impact on transfer practices remains under-characterized.

Objectives: To understand the impacts of hospital affiliation on transfer practices and hospital resource utilization.

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Empiric anti-fungals are frequently administered in patients with non-colonic gastrointestinal (GI) perforations, but there is limited evidence of their benefit. We hypothesized that empiric anti-fungals would offer no clinical benefit compared with a standard course of antimicrobial therapy. This multi-center prospective cohort study included patients ≥18 years old undergoing operative management for non-colonic GI perforations across 15 centers between August 2021 and January 2024.

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Background: Pulmonary contusion (PC) is considered a relative contraindication to surgical stabilization of rib fractures (SSRF). This study compared outcomes in patients undergoing SSRF vs. non-operative management (NOM).

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Introduction: The utility of pancreaticoduodenectomy (PD) for high-grade traumatic injuries remains unclear and data surrounding its use are limited. We hypothesized that PD does not result in improved outcomes when compared with non-PD surgical management of grade IV-V pancreaticoduodenal injuries.

Methods: This is a retrospective, multicenter analysis from 35 level 1 trauma centers from January 2010 to December 2020.

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Background: Intraoperative adverse events (iAEs) during general surgery can lead to significant morbidity and healthcare burden, yet their impact remains underexplored. We aimed to estimate the nationwide incidence of iAEs in general surgery and explore their associations with mortality, complications, length of stay, and costs.

Methods: We conducted a retrospective cohort study using the Nationwide Readmissions Database 2019 and included adult patients (aged 18 years and older) who underwent general surgical procedures.

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Background: The prolonged use of percutaneous cholecystostomy tubes (PCTs) in patients with acute cholecystitis, deemed inoperable, is fraught with complications. Transpapillary cholecystoduodenal stenting (TCDS) is an alternative technique that restores the physiologic outflow of bile, avoiding the need for an external drain. However, the long-term safety and efficacy of this approach remain unclear.

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Background: The Predictive Optimal Trees in Emergency Surgery Risk (POTTER) calculator, a widely used interpretable artificial intelligence risk calculator, has been validated in population-based studies and shown to predict outcomes in patients who underwent emergency general surgery better than surgeons. We sought to prospectively validate POTTER.

Study Design: Patients undergoing an emergency exploratory laparotomy for nontrauma indications at 2 academic medical centers between June 2020 and March 2022 were included.

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Article Synopsis
  • Care fragmentation in elderly patients post-hospital discharge is linked to higher morbidity and mortality, necessitating a study to identify contributing factors and their relation to mortality rates.
  • A retrospective analysis of over 447,000 patients showed that 24.3% faced unplanned readmissions within 90 days, with 20.8% experiencing care fragmentation, particularly among older females.
  • Factors like living in rural areas, low-income neighborhoods, and specific discharge decisions significantly predicted care fragmentation, which correlates with increased mortality rates in this population.
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Background: Emergency general surgery performed among patients over 65 years of age represents a particularly high-risk population. Although interhospital transfer has been linked to higher mortality in emergency general surgery patients, its impact on outcomes in the geriatric population remains uncertain. We aimed to establish the effect of interhospital transfer on postoperative outcomes in geriatric emergency general surgery patients.

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Purpose: For polytrauma patients with bilateral femoral shaft fractures (BFSF), there is currently no consensus on the optimal timing of surgery. This study assesses the impact of early (≤ 24 h) versus delayed (>24 h) definitive fixation on clinical outcomes, especially focusing on concomitant versus staged repair. We hypothesized that early definitive fixation leads to lower mortality and morbidity rates.

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Article Synopsis
  • Patients with duodenal leaks (DL) who received enteral nutrition (EN) experienced shorter time to leak closure, fewer infectious complications, and reduced hospital stays compared to those receiving parenteral nutrition (PN) or a combination of both.
  • The study analyzed data from 113 patients across 35 trauma centers, highlighting that EN patients had significantly fewer days without oral intake and less severe complications.
  • The findings suggest that EN is a preferable nutritional strategy for DL patients, as it promotes quicker recovery and fewer hospital-related issues.
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Background: The impact of COVID-19 infection at the time of traumatic injury remains understudied. Previous studies demonstrate that the rate of COVID-19 vaccination among trauma patients remains lower than in the general population. This study aims to understand the impact of concomitant COVID-19 infection on outcomes in trauma patients.

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Article Synopsis
  • About 61 million people in the U.S. have a disability, but not much is known about how this affects their hospital care after surgery.
  • The study looked at over 378,000 patients who had emergency surgeries and compared those with disabilities to those without, finding that disabled patients had more health issues afterward.
  • It showed that disabled patients had a higher chance of returning to the hospital within 30 days, suffered more complications, and stayed in the hospital longer than those without disabilities.
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Background: Despite the high prevalence of disability conditions in the US, their association with access to minimally invasive surgery (MIS) remains under-characterized.

Objective: To understand the association of disability conditions with rates of MIS and describe nationwide temporal trends in MIS in patients with disability conditions.

Methods: We conducted a retrospective cohort study using the Nationwide Readmission Database (2016-2019).

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  • This study investigated if lower extremity amputation in civilian injuries increases the risk of venous thromboembolism (VTE), specifically pulmonary embolism (PE) and deep vein thrombosis (DVT).
  • Researchers analyzed data from over 145,000 patients with severe leg injuries, comparing those who underwent amputation with those who had limb salvage.
  • Findings showed that amputee patients had significantly higher rates of both PE (4.2% vs. 2.5%) and DVT (6.5% vs. 3.4%), highlighting the increased risk of VTE after traumatic limb loss.
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Introduction: In Massachusetts, US, medical cannabis legalisation was associated with increased paediatric cannabis exposure cases, including emergency department (ED) visits and hospitalizations. The impact of recreational cannabis legalisation (RCL) on paediatric exposures in Massachusetts has yet to be studied.

Methods: To compare the incidences before and after RCL in Massachusetts, US, we queried the data on paediatric cannabis exposure cases in 2016-2021 from the Centre for Healthcare and Analysis and Injury Surveillance Programme at the Massachusetts Department of Public Health.

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Purpose: In conflict zones, providers may have to decide between delaying time-sensitive surgeries or performing operative interventions in the field, potentially subjecting patients to significant infection risks. We conducted a single-arm crossover study to assess the feasibility of using an ultraportable operating room (U-OR) for surgical procedures on a porcine cadaver abdominal traumatic injury model in an active war zone.

Methods: We enrolled participants from an ASSET-type course designed to train Ukrainian surgeons before deployment to active conflict zones.

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Background: Recent literature has shown that surgical stabilization of rib fractures benefits patients with rib fractures accompanied by pulmonary contusion; however, the impact of timing on surgical stabilization of rib fractures in this patient population remains unexplored. We aimed to compare early versus late surgical stabilization of rib fractures in patients with traumatic rib fractures and concurrent pulmonary contusion.

Methods: We selected all adult patients with isolated blunt chest trauma, multiple rib fractures, and pulmonary contusion undergoing early (<72 hours) versus late surgical stabilization of rib fractures (≥72 hours) using the American College of Surgeons Trauma Quality Improvement Program 2016 to 2020.

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Background: COVID-19 vaccination rates in the hospitalized trauma population are not fully characterized and may lag behind the general population. This study aimed to outline COVID-19 vaccination trends in hospitalized trauma patients and examine how hospitalization influences COVID-19 vaccination rates.

Methods: We conducted a retrospective institutional study using our trauma registry paired with the COVID-19 vaccination ENCLAVE registry.

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Background: A novel hydrophobically modified chitosan (hm-chitosan) polymer has been previously shown to improve survival in a non-compressible intra-abdominal bleeding model in swine. We performed a 28-day survival study to evaluate the safety of the hm-chitosan polymer in swine.

Methods: Female Yorkshire swine (40-50 kg) were used.

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More than 20% of the population in the United States suffers from a disability, yet the impact of disability on post-operative outcomes remains understudied. This analysis aims to characterize post-operative infectious complications in patients with disability. This was a retrospective review of the National Readmission Database (2019) among patients undergoing common general surgery procedures.

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Infectious complications lead to worse post-operative outcomes and are used to compare hospital performance in pay-for-performance programs. However, the impact of social and behavioral determinants of health on infectious complication rates after emergency general surgery (EGS) remains unclear. All patients undergoing EGS in the 2019 Nationwide Readmissions Database were included.

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Background: Surgical site infections (SSI) are a common complication of laparotomy incisions. The role of Negative Pressure Wound Therapy (NPWT) in preventing SSIs has not yet been explored in a nationwide analysis. We aimed to evaluate the association of the prophylactic use of NPWT with SSIs in patients undergoing an emergency laparotomy procedure.

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