Outcomes of Radiation Overlap and Margin Length in Intracoronary Brachytherapy for In-Stent Restenosis.

Background: In-stent restenosis (ISR) is a common complication following coronary stent implantation. Intracoronary brachytherapy (ICBT) has re-emerged as an effective treatment modality. However, optimal procedural strategies, including the role of radiation source overlap and adequate margin length, remain unclear.

Intravascular brachytherapy versus drug-coated balloons for in-stent restenosis: A two-center two-strategy comparison.

Background: In-stent restenosis remains a persistent challenge in interventional cardiology. While both intravascular brachytherapy (IVB) and drug-coated balloons (DCB) have been used to treat this condition, their comparative effectiveness has never been evaluated.

Objectives: To compare the efficacy and safety of IVB versus DCB for the treatment of in-stent restenosis.

Staged I-125 Eye Plaque Brachytherapy for the Treatment of Large Uveal Melanoma: A Single Institution Experience.

Purpose: Eye plaque brachytherapy (EPBT) is not routinely performed on large uveal melanomas (UM) as commercially available plaques often cannot ensure adequate coverage of the tumor with high doses of 85 Gy. The purpose of this study is to report our institution's experience with a clinically novel approach of staged EPBT in treating large UM in 2 treatments, 45 Gy in each treatment.

Methods And Materials: Patients were included if they underwent staged EPBT at our institution between 2020 and 2023.

Outcomes of intravascular brachytherapy for in-stent restenosis in small versus large coronary vessels.

Background: In-stent restenosis (ISR) remains a significant challenge in coronary intervention. Vessel size is recognized as an important predictor of outcomes following percutaneous coronary interventions, with smaller vessels traditionally associated with higher rates of restenosis. This study evaluates the clinical outcomes of vascular brachytherapy for ISR stratified by vessel size.

Development and implementation of a brachytherapy procedure scoring system to optimize clinic and physics staffing schedule: A retrospective study of a single institution with a busy brachytherapy program.

Purpose: Brachytherapy (BT) is a time and resource intensive treatment modality. Constraints to efficiency and throughput include resource, staff and physician availability. Herein, we introduce a daily BT procedure scorecard, designed to ensure adequate resource allocation based on the type of procedure(s) being performed.

Re-treatment of locally recurrent uveal melanoma with repeat eye plaque I-125 brachytherapy: A single institution experience.

Purpose: Eye plaque brachytherapy (EPBT) is the most common treatment for uveal melanoma with high local control rates of 95-100%. When local recurrences occur following EPBT, salvage options include enucleation, transpupillary thermotherapy (TTT), external beam radiation, or re-irradiation with EPBT. The purpose of this study is to report our institution's experience with EPBT re-irradiation for locally recurrent uveal melanoma.

Retrospective Analysis of Radiation-Induced Complications of Uveal Melanoma Patients Treated With Brachytherapy in the Era of Anti-VEGF.

Purpose: To associate clinical factors and radiation doses delivered by iodine-125 plaque brachytherapy to visual outcomes and development of radiation-induced ocular complications in patients with uveal melanoma in the era of anti-vascular endothelial growth factor (anti-VEGF) injections.

Design: Retrospective cohort study.

Methods: A retrospective chart review was performed for 225 patients treated with iodine-125 brachytherapy for uveal melanoma.

A feasibility study of utilizing a cadaveric training model for novel robotic bladder cancer brachytherapy techniques.

Purpose: The current standard of care for muscle-invasive bladder cancer is neoadjuvant chemotherapy followed by radical cystectomy with lymph node dissection. Although this treatment provides therapeutic benefit, it is associated with notable morbidity. Bladder sparing techniques, such as concurrent chemo-radiation, are less invasive and prioritize organ preservation in individuals with invasive bladder cancer and offer comparable disease control.

Enhancement of Long-Term External-Internal Correlation by Phase-Shift Detection and Correction Based on Concurrent External Bellows and Internal Navigator Signals.

Purpose: The purpose of this study was to enhance the correlation between external and internal respiratory motions by dynamically determining and correcting the patient-specific phase shift between external and internal respiratory waveforms acquired concurrently during respiratory-correlated 4-dimensional magnetic resonance imaging scans.

Methods And Materials: Internal-navigator and external-bellows waveforms were acquired simultaneously during 6- to 15-minute respiratory-correlated 4-dimensional magnetic resonance imaging scans in 10 healthy participants under an institutional review board-approved protocol. The navigator was placed at the right lung-diaphragm interface, and the bellows were placed ∼5 cm inferior to the sternum.

Direct Comparison of Respiration-Correlated Four-Dimensional Magnetic Resonance Imaging Reconstructed Using Concurrent Internal Navigator and External Bellows.

Purpose: To compare the image quality of amplitude-binned 4-dimensional magnetic resonance imaging (4DMRI) reconstructed using 2 concurrent respiratory (navigator and bellows) waveforms.

Methods And Materials: A prospective, respiratory-correlated 4DMRI scanning program was used to acquire T2-weighted single-breath 4DMRI images with internal navigator and external bellows. After a 10-second training waveform of a surrogate signal, 2-dimensional MRI acquisition was triggered at a level (bin) and anatomic location (slice) until the bin-slice table was completed for 4DMRI reconstruction.

A Novel Respiratory Motion Perturbation Model Adaptable to Patient Breathing Irregularities.

Purpose: To develop a physical, adaptive motion perturbation model to predict tumor motion using feedback from dynamic measurement of breathing conditions to compensate for breathing irregularities.

Methods And Materials: A novel respiratory motion perturbation (RMP) model was developed to predict tumor motion variations caused by breathing irregularities. This model contained 2 terms: the initial tumor motion trajectory, measured from 4-dimensional computed tomography (4DCT) images, and motion perturbation, calculated from breathing variations in tidal volume (TV) and breathing pattern (BP).