Unveiling the mechanism of amelioration of adjuvant-induced rheumatoid arthritis by Drynaria quercifolia rhizome extract using network pharmacology and gene expression-based studies.

Rhizomes of Drynaria quercifolia have long been traditionally used to manage rheumatic pain. However, there is limited research supporting this traditional practice and insufficient evidence demonstrating the molecular mechanisms of action of plant-derived bioactives in rheumatoid arthritis (RA). The current study aims to identify the effective components in Drynaria quercifolia methanol rhizome extract (DME) and their probable pharmacological mechanisms in alleviating Rheumatoid Arthritis (RA) using network-pharmacology, molecular docking, molecular-dynamics simulations, and gene expression-based validation.

Equisetum diffusum whole plant methanol extract attenuates rheumatoid arthritis by modulating the expression of key inflammatory biomarkers in rat models.

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with subsequent damage to the bone joints with a global incidence rate of 0.5-1%. To combat with RA various commercially available anti-inflammatory drugs like non-steroidal anti-inflammatory drugs (NSAIDs) are commonly practiced; however, their long-term exposure often results in eliciting gastrointestinal and renal toxicity.

Antidiabetic activities of aerial part of Willd. extract: an , , and approach.

Willd., a significant medicinal plant in India's Darjeeling Himalayan region. The current study aims to assess the antidiabetic efficacy of the aerial part of Willd.

In silico, in vitro, and in vivo acute and sub-acute toxicity profiling of whole plant methanol extract of Equisetum diffusum D. Don from the sub-Himalayan West Bengal, India, having ethnobotanical uses.

Background: Equisetum diffusum D. Don commonly known as 'Himalayan horsetail', has been traditionally used in the treatment of back pain, bone fracture and dislocation, and arthritis by various tribal communities of India. Our previous study confirmed the anti-inflammatory efficacy of the plant through in silico, in vitro, and in vivo model studies.

Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources.

Fruits are crucial components of a balanced diet and a good source of natural antioxidants, that have proven efficacy in various chronic illnesses. Various kinds of waste generated from fruit industries are considered a global concern. By utilizing this fruit waste, the international goal of "zero waste" can be achieved by sustainable utilization of these waste materials as a rich source of secondary metabolites.

Revealing Probiotic Potential of Strains Isolated From Traditionally Fermented and Healthy Human Gut.

In this study, the two lactic acid bacterial strains and previously isolated from soft , a traditionally fermented milk product prepared by the indigenous community of Sikkim Himalayas and healthy human gut were used. In this study, we attempted to investigate the probiotic attributes, safety, and health beneficial role, and hypercholesterolemia of and . Both probiotic potential strains showed good hypocholesterolemic activity along with tolerance to acid pH (2 and 2.

Validating potent anti-inflammatory and anti-rheumatoid properties of Drynaria quercifolia rhizome methanolic extract through in vitro, in vivo, in silico and GC-MS-based profiling.

Background: The fronds of Drynaria quercifolia have traditionally been used in rheumatic pain management. The goal of the present study was to validate the potent anti-inflammatory and anti-rheumatoid properties of the methanolic-extract of its rhizome using in vitro, in vivo and in silico strategies.

Methods: The plant was collected and the methanolic extract was prepared from its rhizome.