Near-Real Surgical Specimens (NRSS): A Novel Platform for Standardized Assessment of Suprachoroidal Drug Delivery.

Purpose: Suprachoroidal (SC) drug delivery is a promising avenue for treating posterior segment ocular diseases. Current ex vivo models, primarily human cadaveric eyes, are limited by tissue variability and altered post-mortem fluid dynamics. We introduce near-real surgical specimens (NRSS), an engineered ocular tissue platform, to overcome these limitations and provide standardized, reproducible evaluation of SC drug delivery.

Daily association between perceived control and resolution of daily stressors strengthens across a decade of adulthood.

Greater perceived control is often associated with better responses to life's stressors. One reason for this link may be that greater perceived control is related to the ability to resolve these stressful experiences. Using longitudinal data from the National Study of Daily Experiences (N = 1766, Mage = 56.

Making a Bad Situation Worse: Race, Poor Health Behaviors, and Daily Family Stressor Reactivity.

Prior research posits that for African Americans, engaging in poor health behaviors (PHBs), such as smoking or drinking, buffers the negative effects of stressful life events. This study explored how PHBs exacerbate (double jeopardy) or buffer reactivity to daily family stressors among African Americans and European Americans ( = 1,931) ages 34-84 from the National Study of Daily Experiences (NSDE II). During 8 days of telephone interviews, respondents reported on family stressors, health behaviors (number of cigarettes and alcoholic beverages), affect, and physical symptoms.

Effects of Genetic Diversity on Health Status and Parasitological Traits in a Wild Fish Population Inhabiting a Coastal Lagoon.

Host genetic variability is relevant to understanding how parasites modulate natural selection in wild fish populations. Coastal lagoons are transitional ecosystems where knowledge lacks on relationships between genotypic diversity with parasitism. The aim of this study was to assess the effect of genetic diversity on host health and parasitological traits in fish inhabiting a Mediterranean lagoon.

Daily associations between stress occurrence and memory lapses across middle and late adulthood: The potential stress-buffering role of positive affect.

Advanced age has been associated with benefits in stress reactivity. However, previous research has not investigated this advantage for daily memory functioning, which is crucial for the quality of life in adulthood. Considering the possible detrimental effects of stressors on daily memory functioning, this study investigated the relationship between stressor occurrence and memory lapses in middle and late adulthood and whether positive affect acts as a stress buffer.

Progressive Retinal Degeneration and Juvenile Nephronophthisis in a Patient with Autosomal Recessive Ciliopathy: A Case Report.

Introduction: Inherited retinal diseases, particularly ciliopathies, often lead to irreversible blindness and are frequently accompanied by systemic manifestations such as nephronophthisis. Current treatment options are limited, necessitating the exploration of supplementary strategies to slow disease progression.

Case Presentation: We present a rare case from a retinal surgery clinic involving a 30-year-old male with autosomal recessive retinitis pigmentosa (ARRP) and juvenile nephronophthisis.

Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decade.

Epigenetic aging measures are novel molecular indicators of biological aging that predict age-related chronic disease. We examined whether several established indices of epigenetic aging mediated the association between life course socioeconomic status (SES) and decrements in kidney function across a decade. Biomarker data were from 252 non-Hispanic (NH) Black and white participants who had consented to genetic analyses in Wave 2 (2004-2009) and 3 (2014-2021) of the Midlife in the United States study (MIDUS).

Covariation of daily stressors and alcohol use among adults aged 50+ years: differences across stressor characteristics and individual factors.

Background: Several theoretical frameworks suggest connections between stress and alcohol use. However, limited existing literature has focused on older adults, and associations may vary across stressor and individual characteristics.

Purpose: The current study extends the stress-drinking literature by assessing the same-day covariation of daily stressors and alcohol use among a national sample of adults aged 50+ years.

Psychological Stress and Cognitive Brain Health: Policies to Reduce Dementia Risk.

Alzheimer's disease and related dementias (ADRD) pose a massive public health challenge, affecting over 6.7 million Americans aged 65 and older-a number projected to double by 2050. Despite advances in pharmacological treatments, there remains no cure or method to reverse the disease.

Greater negative affective responsivity to daily stressors is positively related to urinary norepinephrine excretion in middle-aged adults.

Despite mounting evidence that greater affective responsivity to naturally occurring daily stressors is associated with increased risk of cardiovascular diseases (CVDs), few studies have examined dysregulation of the sympathetic nervous system as a potential mechanism. We hypothesized that greater affective responsivity to daily stressful events would be related to increased urinary catecholamine excretion. Daily stress processes (8-day daily diary) were assessed in 715 middle-aged adults (56 ± 11 yr; 57% female) from the Midlife in the United States Study.

Daily Stress and Cortisol Patterns in Midlife and Older Parents of Children With Developmental Disabilities.

Objectives: The current study aims to investigate the association between daily stressful experiences and daily diurnal cortisol in midlife and older parents of children with developmental disabilities (DD) and a matched sample of parents of children without DD.

Methods: Analyses were employed using data from the third wave of the National Study of Daily Experiences (NSDE 3) within the Midlife in the United States (MIDUS) study, a population-based sample. The study sample included 55 parents of children with DD and 591 comparison parents who provided diurnal cortisol data.

Chronic loneliness and longitudinal changes in cognitive functioning.

Background: Loneliness is a worldwide concern with significant health implications that may be a significant risk factor for Alzheimer's disease and related dementias. In light of the importance of detecting early cognitive changes and risk factors influencing cognitive health, this study examined whether chronic loneliness predicted cognitive changes among young and middle-aged adults.

Methods: This study utilizes data from a longitudinal measurement burst study spanning over two years, comprising three waves of data collection.

Virtual Reality Visual Field Testing in Glaucoma: Benefits and Drawbacks.

Importance: Virtual reality-assisted visual field testing (VRVFT) is a novel modality for evaluating glaucoma progression, offering potential advantages over standard automated perimetry (SAP). To date, no narrative literature review has comprehensively discussed the benefits and drawbacks of VRVFT for glaucoma patients.

Observations: A narrative literature review was conducted using PubMed and MEDLINE via EBSCOhost, covering articles published from 2014 to October 2023.

Age and Inflammation: Insights on "Age Three Ways" from Midlife in the United States Study.

Introduction: Chronological age is a particularly well-known indicator of variability in systemic inflammation. Other pertinent aspects of age (or "age proxies") - subjective or epigenetic age - may offer nuanced information about age and inflammation associations. Using the Midlife in the United States Study, we explored how chronological, subjective, and epigenetic age were associated with inflammation.

Negative affective responsivity to daily stressors in young adults: The influence of depressive symptom severity.

Background: Evidence suggests that adults with major depressive disorder appraise daily stressor events as more severe and report stronger stressor-related negative emotions than non-depressed adults. Despite the growing number of young adults (~18-25 yrs) experiencing depressive symptoms in the absence of a formal clinical diagnosis, limited studies have examined whether current depressive symptom severity influences affective responsivity to daily stressors in young men and women. We tested the hypotheses that greater depressive symptom severity would be related to greater negative stressor appraisal characteristics and greater affective responsivity to daily stressors but not to stressor exposure frequency.

Interventional Retrospective Case Series of Patients Undergoing Treatment Intervals of More Than Twenty-Four (24) Weeks With Faricimab.

The aim of this study is to evaluate the efficacy and safety of intravitreal faricimab dosing interval at and beyond 24 weeks in patients with diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD). This study is a retrospective case series of eight patients with persistent DME and nAMD who received intravitreal faricimab at and beyond the 24-week (6-month) dosing interval regimen. The majority of patients experienced an improved mean best-corrected visual acuity (BCVA) of 9.

Housing insecurity pathways to physiological and epigenetic manifestations of health among aging adults: a conceptual model.

Introduction: Housing insecurity is a social determinant of health, as evidenced by its associations with mental, physical, and biological outcomes. The scientific understanding of the mechanisms by which housing insecurity is associated with health is still limited. This review adapts existing stress process models to propose a conceptual model illustrating potential pathways linking the specific stressor of housing insecurity to physiological and epigenetic manifestations of stress among aging adults.

To Treat or Not to Treat? Resolving the Question of Subretinal and Intraretinal Fluid in Age-Related Macular Degeneration: A Narrative Review.

Neovascular age-related macular degeneration (nAMD) is associated with considerable quality of life and economic burden. nAMD is characterized by pathological neovascularization, leading to the accumulation of retinal fluid. Intraretinal fluid (IRF) is a major contributor to vision loss and may predict response to treatment.

Daily Cognition in the Family Context: The Complex Associations Between Memory Lapses, Family Relationships, and Affect in Middle-Aged and Older Adults.

Background And Objectives: The analysis of daily memory lapses is an underutilized approach to understanding daily experiences of cognitive functioning. The present study adopts this approach, with the goals of exploring how the quality of family relationships predicts the frequency of daily memory lapses and moderates the link between daily memory lapses and daily affect.

Research Design And Methods: We used longitudinal data from the third wave of Midlife in the United States and the National Study of Daily Experiences to assess our research goals.

Adaptive Just-in-Time Intervention to Reduce Everyday Stress Responses: Protocol for a Randomized Controlled Trial.

Background: Personalized approaches to behavior change to improve mental and physical health outcomes are needed. Reducing the intensity, duration, and frequency of stress responses is a mechanism for interventions to improve health behaviors. We developed an ambulatory, dynamic stress measurement approach that can identify personalized stress responses in the moments and contexts in which they occur; we propose that intervening in these stress responses as they arise (ie, just in time; JIT) will result in positive impacts on health behaviors.

Changes in daily stress reactivity and changes in physical health across 18 years of adulthood.

Background: Stress plays a pivotal role in physical health. Although many studies have linked stress reactivity (daily within-person associations between stress exposure and negative affect) to physical health outcomes, we know surprisingly little about how changes in stress reactivity are related to changes in physical health.

Purpose: The current study examines how change in stress reactivity over 18 years is related to changes in functional health and chronic health conditions.

Designing work for healthy sleep: A multidimensional, latent transition approach to employee sleep health.

Healthy sleep is essential to employee well-being and productivity, but many modern workers do not obtain adequate sleep. Are technology-related changes to job design (i.e.

Retinal fluid quantification using a novel deep learning algorithm in patients treated with faricimab in the TRUCKEE study.

Background: Investigate retinal fluid changes via a novel deep-learning algorithm in real-world patients receiving faricimab for the treatment of neovascular age-related macular degeneration (nAMD).

Methods: Multicenter, retrospective chart review and optical coherence tomography (OCT) image upload from participating sites was conducted on patients treated with faricimab for nAMD from February 2022 to January 2024. The Notal OCT Analyzer (NOA) algorithm provided intraretinal, subretinal and total retinal fluid for each scan.

Daily reciprocal relationships between affect, physical activity, and sleep in middle and later life.

Background: The daily dynamics among affect, physical activity, and sleep are often explored by taking a unidirectional approach. Yet, obtaining a comprehensive understanding of the reciprocal dynamics among affect and health behaviors is crucial for promoting daily well-being.

Purpose: This study examined the reciprocal associations among affect, physical activity, and sleep in daily life in a U.

Associations between Recession Hardships and Subjective and Objective Sleep Measures in the Midlife in the United States Study: Race and Gender Differences.

Objectives: This study investigates the associations of retrospective reports of Recession hardships with 10-year changes in subjective and objective indicators of sleep, and whether these associations differ by race and gender.

Methods: 501 adults (14.57% Black; 54.