Cloning and Functional Characterization of a Novel Brevinin-1-Type Peptide from with Anticancer Activity.

Despite significant medical advancements, two major health challenges persist: antibiotic resistance in microbial pathogens and drug resistance in cancer cells. To address these issues, research has increasingly focused on discovering novel natural compounds with dual antimicrobial and anticancer activities. Among such candidates, antimicrobial peptides (AMPs) have attracted attention due to their ability to selectively target microbial and cancer cells while exhibiting minimal toxicity toward normal cells.

Steric Control in Low-Valent Mn Diamide Complexes: Contrasting Magnesium and Manganese in N and Benzene Activation.

Reduction of Mn precursors with bulky diamide ligands provided access to a complex with the longest known Mn-Mn bond and to a rare example of N activation at high-spin Mn centers. While some instructive parallels can thus be drawn to observations made for Mg analogues, the accessibility of filled d orbitals in the respective Mn intermediates leads to a distinct behavior toward benzene that undergoes an oxidative addition.

The reliability of deep learning models in assessing the shoulder arthroscopic field's visual clarity in relation to bleeding.

Background: The clarity of visualization in shoulder arthroscopy is significantly influenced by intraoperative bleeding. This study aims to develop deep learning models to classify the visual clarity of arthroscopic shoulder images and evaluate their reliability compared to rater assessment.

Methods: We retrospectively reviewed videos from 113 shoulder arthroscopies, using 63 patients' videos to create a 3750-image training dataset and 50 patients' videos to evaluate the reliability and agreement of the trained models.

Possible use of digital variance angiography in uterine fibroid embolization: a retrospective observational study.

Purpose: Digital variance angiography (DVA), a recently developed image processing technology, provides a higher contrast-to-noise ratio (CNR) and better image quality during lower limb interventions than digital subtraction angiography (DSA). Our aim was to investigate whether the quality reserve of DVA can also be observed in uterine fibroid embolization (UFE).

Methods: In this retrospective observational study, the CNR and image quality of DSA and DVA images from 56 patients (mean ± standard deviation age: 44.

Assembly of Functionalized Organic Fragments via Reductive Activation and (Cross)-Coupling of CH, CO, CO and/or H Using a Magnesium-Dinitrogen Complex.

Reactions of 1,2-dimagnesioethane compound [{K(NON)Mg}(μ-CH)] (NON = 4,5-bis(2,4,6-tricyclohexylanilido)-2,7-diethyl-9,9-dimethyl-xanthene), formed by the two-electron reduction of ethene with a dimagnesium/dipotassium complex of reduced N, viz. [{K(NON)Mg}(μ-N)], with CO and CO have been explored. In the case of the reaction with CO, cross-coupling of the reduced ethene fragment with two molecules of CO gave a heterobimetallic complex of the parent cyclobutenediolate dianion, [{K(NON)Mg}(μ-OCH)], which when exposed to THF gave adduct [{K(NON)Mg}(μ-OCH)(THF)].

Dioxins and Related Compounds in Sediment and Soil from Craft Villages and Industrial Areas in Northern Vietnam.

This study focuses on the determination of dioxins and related compounds (DRCs) in sediment and soil samples gathered from craft villages and industrial zones in Bac Ninh province, northern Vietnam. The PCDD/Fs and DL-PCBs levels in sediment samples ranged from 8.34 to 1302 pg/g and 34.

Lycopodiaceae herb from Vietnam as a promising medicinal source of natural hupezine and novel huperzine-producing endophytic fungi.

Objectives: (1) To evaluate the potential of producing huperzine (Hup) and anticholinesterase (AChE) activities of nine native Lycopodiaceae species collected in Vietnam; (2) Isolation, identification and characterization of a novel fungus producing both HupA and HupB isolated from Lycopodium casuarinoides Spring.

Results: All methanolic extracts of nine plants showed AChE inhibition from 8.55 to 71.

Predictive validity of interleukin 6 (IL-6) for the mortality in critically ill COVID-19 patients with the B.1.617.2 (Delta) variant in Vietnam: a single-centre, cross-sectional study.

Objectives: To investigate the serum IL-6 levels and their rate of change in predicting the mortality of critically ill patients with COVID-19 in Vietnam.

Design: A single-centre, cross-sectional study.

Setting: An Intensive Care Centre for the Treatment of Critically Ill Patients with COVID-19 in Ho Chi Minh City, Vietnam.

Digitally-defined ultrathin transparent wireless sensor network for room-scale imperceptible ambient intelligence.

Wireless and battery-free radio-frequency (RF) sensors can be used to create physical spaces that ambiently sense and respond to human activities. Making such sensors ultra-flexible and transparent is important to preserve the aesthetics of living environments, accommodate daily activities, and functionally integrate with objects. However, existing RF sensors are unable to simultaneously achieve high transparency, flexibility, and the electrical conductivity required for remote room-scale operation.

Enhancing the quality and consumer satisfaction of dragon fruit beverage production: The effects of geological origin and processing conditions.

Objectives: In this study, the impacts of various processing parameters on the quality and consumer satisfaction of dragon fruit beverages were investigated in order to establish an informative framework for the manufacturing of commercial dragon fruit beverages, focusing on health benefits and safety for consumers, and sensory appeal of the products.

Methods: This study employed various analytical methods to quantify some important phytochemical compounds in dragon fruit juice such as total and reducing sugars, vitamin C, betacyanins, anthocyanins, polyphenol, and so forth. This study also employed the Box-Behnken response surface experimental design to optimize various processing parameters for quality and consumer satisfaction, which include enzymatic pectin hydrolysis parameters and formulation for dragon fruit energy drink.

An isolable stannaimine and its cycloaddition/metathesis reactions with carbon dioxide.

An N-heterocyclic stannylene :Sn(NON) (NON = [O(SiMeNAd)], Ad = 1-adamantyl), reacts rapidly with 2,4,6-tricyclohexylphenyl azide (TCHP)N, affording a stannaimine, (NON)SnN(TCHP). Solutions of (NON)SnN(TCHP) react immediately with carbon dioxide (CO) to give a [2+2]-cycloaddition product, which, upon heating, subsequently engages in a metathesis process to give [Sn(NON)(μ-O)] and the bulky isocyanate, (TCHP)NCO.

Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature.

Aims: Circulating levels of sphingosine 1-phosphate (S1P), an HDL-associated ligand for the endothelial cell (EC) protective S1P receptor-1 (S1PR1), are reduced in disease states associated with endothelial dysfunction. Yet, as S1PR1 has high affinity for S1P and can be activated by ligand-independent mechanisms and EC autonomous S1P production, it is unclear if relative reductions in circulating S1P can cause endothelial dysfunction. It is also unclear how EC S1PR1 insufficiency, whether induced by deficiency in circulating ligand or by S1PR1-directed immunosuppressive therapy, affects different vascular subsets.

Synthesis and Characterization of Bulky 1,3-Diamidopropane Complexes of Group 2 Metals (Be-Sr).

Reaction of lithium 1,3-diamidopropane Li(NCN) (NCN=[{(Trip)NCH}CH], Trip=2,4,6-triisopropylphenyl) with BeBr(OEt) gave the diamido beryllium complex, [(NCN)Be(OEt)]. Deprotonation reactions between the bulkier 1,3-diaminopropane (NCN)H (NCN=[{(TCHP)NCH}CH], TCHP=2,4,6-tricyclohexylphenyl) and magnesium alkyls afforded the adduct complexes [(NCN)Mg(OEt)] and [(NCN)Mg(THF)], depending on the reaction conditions employed. Treating [(NCN)Mg(THF)] with the N-heterocyclic carbene :C{(MeNCMe)} (TMC) gave [(NCN)Mg(TMC)] via substitution of the THF ligands.

A Comprehensive Evaluation of Dioxins and Furans Occurrence in River Sediments from a Secondary Steel Recycling Craft Village in Northern Vietnam.

This first study investigated the presence of dioxins and furans in river sediments around a craft village in Vietnam, focusing on Secondary Steel Recycling. Sediment samples were collected from various locations along the riverbed near the Da Hoi Secondary Steel Recycling village in Bac Ninh province. The analysis was conducted using a HRGC/HRMS-DFS device, detecting a total of 17 dioxin/furan isomers in all samples, with an average total concentration of 288.

Enforcing Metal-Arene Interactions in Bulky -Terphenyl Bis(anilide) Complexes of Group 2 Metals (Be-Ba): Potential Precursors for Low-Oxidation-State Alkaline Earth Metal Systems.

An extremely bulky -terphenyl bis(aniline), -CH{CH[N(H)TCHP]-2} (TCHP = 2,4,6-tricyclohexylphenyl) TerphH, has been developed. Deprotonation of a less bulky analogue, TerphH (Dip = 2,6-diisopropylphenyl), with BePh affords the bimetallic system, [(BePh)(μ-Terph)] . Treating either TerphH or TerphH with Mg{CH(SiMe)} gives the monomeric bis(anilide) complexes [Mg(Terph)] (Ar = Dip , TCHP ) which display rare examples of η-arene coordination to the metal center.

Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models.

Accumulation of sphingolipids, especially sphingosines, in the lysosomes is a key driver of several lysosomal storage diseases. The transport mechanism for sphingolipids from the lysosome remains unclear. Here, we identified SPNS1, which shares the highest homology to SPNS2, a sphingosine-1-phosphate (S1P) transporter, functions as a transporter for lysolipids from the lysosome.

Synthetic mRNA delivered to human cells leads to expression of Cpl-1 bacteriophage-endolysin with activity against .

Endolysins are bacteriophage-encoded hydrolases that show high antibacterial activity and a narrow substrate spectrum. We hypothesize that an mRNA-based approach to endolysin therapy can overcome some challenges of conventional endolysin therapy, namely organ targeting and bioavailability. We show that synthetic mRNA applied to three human cell lines (HEK293T, A549, HepG2 cells) leads to expression and cytosolic accumulation of the Cpl-1 endolysin with activity against Addition of a human lysozyme signal peptide sequence translocates the Cpl-1 to the endoplasmic reticulum leading to secretion (hlySP-sCpl-1).

Biallelic variation in the choline and ethanolamine transporter underlies a pleiotropic disease spectrum from adult neurodegeneration to severe developmental disorders.

encodes Feline leukemia virus subgroup C receptor 1 (FLVCR1), a solute carrier (SLC) transporter within the Major Facilitator Superfamily. FLVCR1 is a widely expressed transmembrane protein with plasma membrane and mitochondrial isoforms implicated in heme, choline, and ethanolamine transport. While knockout mice die with skeletal malformations and defective erythropoiesis reminiscent of Diamond-Blackfan anemia, rare biallelic pathogenic variants are linked to childhood or adult-onset neurodegeneration of the retina, spinal cord, and peripheral nervous system.

MFSD7c functions as a transporter of choline at the blood-brain barrier.

Mutations in the orphan transporter MFSD7c (also known as Flvcr2), are linked to Fowler syndrome. Here, we used Mfsd7c knockout (Mfsd7c) mice and cell-based assays to reveal that MFSD7c is a choline transporter at the blood-brain barrier (BBB). We performed comprehensive metabolomics analysis and detected differential changes of metabolites in the brains and livers of Mfsd7cembryos.

The Bjøntegaard Bible Why Your Way of Comparing Video Codecs May Be Wrong.

In this paper, we provide an in-depth assessment on the Bjøntegaard Delta. We construct a large data set of video compression performance comparisons using a diverse set of metrics including PSNR, VMAF, bitrate, and processing energies. These metrics are evaluated for visual data types such as classic perspective video, 360° video, point clouds, and screen content.

Ambient health sensing on passive surfaces using metamaterials.

Ambient sensors can continuously and unobtrusively monitor a person's health and well-being in everyday settings. Among various sensing modalities, wireless radio-frequency sensors offer exceptional sensitivity, immunity to lighting conditions, and privacy advantages. However, existing wireless sensors are susceptible to environmental interference and unable to capture detailed information from multiple body sites.