Comparison of Effects of Remimazolam and Midazolam plus Sevoflurane on Intraoperative Hemodynamics and Opioid Administration: A Retrospective Cohort Study.

Background: Remimazolam is an ultrashort-acting benzodiazepine that maintains stable hemodynamics during anesthesia. However, few reports have focused on hemodynamic stability and opioid use during cardiac surgery with remimazolam. We hypothesized that administration of remimazolam for induction and maintenance of anesthesia for transcatheter aortic valve implantation would maintain hemodynamics as effectively as conventional anesthetics and allow use of an appropriate dose of opioids.

"Discrepancy between subjective and objective assessments focusing on item-level symptom improvement in repetitive transcranial magnetic stimulation therapy for treatment-resistant depression: A two-site prospective study".

Repetitive transcranial magnetic stimulation (rTMS) therapy is an effective treatment for treatment-resistant depression (TRD). However, discrepancies between subjective and objective assessments of treatment responses remain underexplored. This study examined discrepancies between clinician-rated and patient-reported scales following acute-phase rTMS therapy, focusing on item-level symptom improvement.

Symptom control and medication adherence in Japanese pediatric and adolescent asthma: A large-scale web-based cross-sectional survey.

Background: Pediatric asthma remains a significant public health concern in Japan, where adherence to updated treatment guidelines and consistent medication use is inconsistent. This study aimed to evaluate current pediatric asthma management practices and identify areas for improvement to inform future strategies.

Methods: A nationwide, web-based cross-sectional survey was conducted among caregivers of children and adolescents aged 0-19 years diagnosed with asthma and receiving care at medical institutions across Japan.

Serum cytokine profiling differentiates underlying diseases in cytokine storm syndrome.

Objective: Cytokine storm syndrome (CSS), commonly associated with hemophagocytic lymphohistiocytosis (HLH), is a fatal hyperinflammatory syndrome. Differentiating the underlying diseases responsible for CSS is essential for timely therapeutic decisions. This study explored the clinical usefulness of serum cytokine profiling in distinguishing underlying diseases in patients with CSS.

Incidence Rate and Risk Factors for In-Hospital Ischemic Stroke among 83,990 Hospitalized Patients.

Background: Details of in-hospital stroke are unknown. This study aimed to clarify the incidence rate and risk factors for in-hospital stroke among all inpatients.

Methods: This retrospective single-center study included consecutive patients admitted to our hospital.

Physical Compatibility of Four Opioid Analgesics with 64 Intravenous Drugs Commonly Used in Palliative Care During Simulated Y-Site Administration.

Co-administration of multiple intravenous drugs via the Y-site is common in palliative care. Information on the compatibility of opioid analgesics with intravenous drugs commonly used in palliative care is lacking. We aimed to determine the physical compatibility of 4 opioid analgesics with 64 drugs during simulated Y-site administration.

Development of Japanese versions of the Autoimmune Bullous Disease Quality of Life and Treatment of Autoimmune Bullous Disease Quality of Life questionnaires.

Patients with autoimmune bullous disease have their quality of life (QOL) affected by both the disease and its treatment burden. While QOL assessment is clinically important, it is often hindered by limited time in clinical practice, highlighting the need for accurate and efficient QOL evaluation tools. However, no validated QOL questionnaires are currently available in Japan.

Associations of food addiction symptomatology with bariatric surgical attrition: a cross-sectional analysis.

Background: Despite the effectiveness of bariatric surgery, there remains a high rate of attrition from surgical programs, highlighting the need to understand factors that influence presurgical attrition rates.

Objectives: To investigate the association between food addiction (FA) symptomatology and attrition from bariatric surgery.

Setting: Surgical weight-loss program at a single academic medical center.

A multisite observational real-world study on the effectiveness of repetitive transcranial magnetic stimulation therapy for patients with treatment-resistant depression in Japan.

The objective of this study was to reveal the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for Japanese patients with treatment-resistant depression (TRD) in clinical practice, based on real-world data from a nationwide multicenter observational study in Japan. Clinical data of patients with TRD treated with rTMS (NeuroStar TMS treatment system) under public insurance coverage were retrospectively collected from 21 institutes nationwide between June 2019 and December 2023. Depression severity was assessed by the 17-item Hamilton Depression Rating Scale (HAMD-17).

PI gain tuning for pressure-based MFCs with Gaussian mixture model.

A vast number of mass flow controllers (MFCs) are used in semiconductor industry. For the stable supply, an efficient production method of MFC is required. The gain tuning of the proportional-integral (PI) control to realize a setting flow rate is essential for efficient mass production.

Association between Stimulation-Site Pain and Clinical Improvement during Repetitive Transcranial Magnetic Stimulation for Patients with Major Depressive Disorders: A Prospective Observational Study at Two Sites.

Introduction: The clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant depression (TRD) in Japan has not been adequately investigated. Furthermore, the relationship between stimulation-site pain and the antidepressant effects of rTMS has not been thoroughly examined. Therefore, this study aimed to clarify (1) the real-world efficacy and safety of rTMS for TRD in Japan and (2) the relationship between stimulation-site pain and clinical improvement of depressive symptoms.

Gut microbiota of one-and-a-half-year-old food-allergic and healthy children.

Background: Intestinal bacteria may play a role in the development of food allergies. This study aimed to analyze and compare the gut microbiota of food-allergic children with that of healthy children of the same age.

Methods: Stool samples were collected from one-and-a-half-year-old food-allergic (FA group, n = 29) and healthy controls (HC group, n = 19).

Impact of Red Blood Cell Transfusion on Subsequent Cardiovascular Events in Patients with Acute Heart Failure and Anemia.

Red blood cell (RBC) transfusion therapy is often performed in patients with acute heart failure (AHF) and anemia; however, its impact on subsequent cardiovascular events is unclear. We examined whether RBC transfusion influences major adverse cardiovascular events (MACE) after discharge in patients with AHF and anemia.We classified patients with AHF and anemia (nadir hemoglobin level < 10 g/dL) according to whether they received RBC transfusion during hospitalization.