Conference Proceedings for the Conference Series.

Traumatic injury is the leading cause of death for individuals aged 1-45 in the USA. Variations in patient management based on geographic locations, community resources, and provider characteristics contribute to disparities in patient outcomes. It is estimated that 20,000 Americans lives could be saved yearly if all trauma centers performed as well as the highest-performing center, which is achievable, in part, through the reduction of inappropriate practice variation.

TRAUMA: making trauma clinical guidance more implementable.

Introduction: Trauma clinical guidance (guidelines, protocols, algorithms, etc) has been shown to improve patient outcomes; however, it is only used in about half of the patients to whom it applies. Guidance implementation is affected by intrinsic factors (eg, guidance format) as well as extrinsic factors (eg, the clinical environment). Recommendations and frameworks have been created to aid in the development of implementable guidance.

Diverse social environments and 10-year all-cause mortality in a cohort of historically excluded racial/ethnic older adults: A latent class analysis of social integration.

Purpose: The association between social integration and mortality in older adults from historically excluded groups may not align with the patterns observed in predominately white samples. We modeled latent groups of social integration and their association with 10-year all-cause mortality in a cohort of older adults from historically excluded racial/ethnic groups.

Methods: In a sub-sample of a national cohort study of older adults, we used latent class analysis to model social integration using ten item indicators spanning couple status, network characteristics, and neighborhood and community connections.

Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling.

During heart disease, the cardiac extracellular matrix (ECM) undergoes a structural and mechanical transformation. Cardiomyocytes sense the mechanical properties of their environment, leading to phenotypic remodeling. A critical component of the ECM mechanosensing machinery, including the protein talin, is organized at the cardiomyocyte costamere.

A Persistent Boron Tetraradical with Tetraphenylethene-Linked Boraphenanthrene-Type Units.

We report the first paramagnetic boron tetraradical, comprising four boraphenanthrene-type units with boryl radical centers bridged by a central tetraphenylethene (TPE) linker. With strongly π-accepting and sterically demanding cyclic(alkyl)(amino) carbene ligands (), spin densities localize on the boron-carbene fragments (92%), consistent with a true boron-centered tetraradical. Magnetic measurements of reveal minimal spin-spin coupling, consistent with four noninteracting = 1/2 centers.